Malignant tumor of neck

Summary

Malignant tumor of neck (MONDO:0021310) is a cancer and 33 clinical trials. Top therapeutic interventions include amifostine, capecitabine, and pafolacianine sodium. A subtype of head and neck cancer — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer
• Clinical trials: 33

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	malignant tumor of neck
Mondo ID	MONDO:0021310
NCIT	C4940
SNOMED CT	363489000
UMLS	C0746787
MedGen	155434
Anatomy (UBERON)	UBERON:0000974
Is cancer (heuristic)	yes

Also known as: cancer of neck · cancer of the neck · malignant neck neoplasm · malignant neck tumor · malignant neck tumour · malignant neoplasm of neck · malignant neoplasm of the neck · malignant tumor of the neck · malignant tumour of the neck · neck cancer

Disease family

This is a subtype of head and neck cancer. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › cancer › head and neck cancer › malignant tumor of neck

Related subtypes (15): nasal cavity cancer, head and neck carcinoma, skull cancer, ocular cancer, malignant cranial nerve neoplasm, malignant ear neoplasm, tongue cancer, cheek mucosa cancer, malignant carotid body paraganglioma, salivary gland cancer, hard palate cancer, gingival cancer, lip cancer, malignant tumor of floor of mouth, angiosarcoma of the scalp

Subtypes (1): pharynx cancer

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 33.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	20
PHASE2	4
PHASE1/PHASE2	3
PHASE1	3
PHASE4	1
PHASE3	1
EARLY_PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT04261179	PHASE4	UNKNOWN	Study Comparing Lymphoseek® vs. Albumin Nanocolloid in Head and Neck, Melanoma and Breast Cancer
NCT06915727	PHASE3	RECRUITING	An Imaging Agent (Pafolacianine) for Identifying Lesions in Pediatric Patients With Primary or Metastatic Solid Tumors
NCT04708470	PHASE1/PHASE2	ACTIVE_NOT_RECRUITING	A Phase I/II Study of Combination Immunotherapy for Advanced Cancers Including HPV-Associated Malignancies, Small Bowel, and Colon Cancers
NCT00266279	PHASE2	COMPLETED	Phase II (Treatment) Study of Oxaliplatin and Capecitabine in Advanced Head and Neck Malignancies
NCT00318890	PHASE1/PHASE2	COMPLETED	Cisplatin and Docetaxel Plus Docetaxel and Radiotherapy With Amifostine for Squamous Cell Carcinoma of the Head and Neck
NCT00798655	PHASE2	COMPLETED	Trial of Postoperative Radiation, Cisplatin, and Panitumumab in Locally Advanced Head and Neck Cancer
NCT00970502	PHASE1/PHASE2	COMPLETED	Erlotinib, Celecoxib and Reirradiation for Recurrent Head and Neck Cancer
NCT03993353	PHASE2	COMPLETED	Tadalafil and Pembrolizumab in Recurrent or Metastatic Head and Neck Cancer
NCT05551767	PHASE2	UNKNOWN	Induction Immunochemotherapy in Stage III-IVa Head and Neck Cancer
NCT02474368	PHASE1	ACTIVE_NOT_RECRUITING	Study Evaluating a Stereotactic Boost/Treatment for Recurrent or Metastatic Cancer of the Head and Neck
NCT04722523	PHASE1	RECRUITING	A Study of Cemiplimab With Chemotherapy and Immunotherapy in People With Head and Neck Cancer
NCT05472506	PHASE1	WITHDRAWN	Oral AHR Antagonist in Combination With Nivolumab in Patients With PD-1 Resistant Metastatic or Recurrent Head and Neck Cancer
NCT00723463	EARLY_PHASE1	COMPLETED	Determine if Apparent Diffusion Coefficient (ADC) Values Can Differentiate Tumors From Normal Tissue
NCT03452774	Not specified	RECRUITING	SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
NCT04673981	Not specified	RECRUITING	Neurosensorial Disorder and Pain in Oral Cavity and Oropharynx Cancer Traited Patients (OCAPA)
NCT05946577	Not specified	NOT_YET_RECRUITING	Association Between Tinnitus and Hearing Loss in Locally Advanced Head and Neck Cancer Treated by Radiotherapy Alone or With Chemotherapy: a Prospective and Multicenter Study
NCT06722508	Not specified	RECRUITING	Exercise and Nutritional Prehabilitation for Head and Neck Cancer Patients
NCT01194466	Not specified	COMPLETED	Transcutaneous Electrical Nerve Stimulation (TENS) and Head and Neck Cancer Pain (HNC) (TENS & HNC)
NCT01910753	Not specified	TERMINATED	Physical Activity Program and Nutrition Therapeutic Education During Treatment of Head and Neck Cancer Population
NCT02374255	Not specified	COMPLETED	Improving Goals of Care Discussion in Advanced Cancer Patients
NCT02714920	Not specified	COMPLETED	DNA Repair Enzyme Signature in Head and Neck Cancer (CHEMRAD)
NCT02738268	Not specified	COMPLETED	Laser Therapy for the Prevention of Radiodermatitis in Head and Neck Patients
NCT03245788	Not specified	COMPLETED	Effectiveness of Lay Navigators in Meeting Cancer Patients’ Non-Clinical Needs: A Pilot Study
NCT03530033	Not specified	UNKNOWN	Lidocaine Reduces Muscle Tremor is Beneficial for Intraoperative Recurrent Laryngeal Nerve Monitoring
NCT03569436	Not specified	COMPLETED	Effectiveness and Safety of Nivolumab in Participants That Have Head and Neck Cancer That Has Come Back or Has Spread
NCT03896958	Not specified	UNKNOWN	The PIONEER Initiative: Precision Insights On N-of-1 Ex Vivo Effectiveness Research Based on Individual Tumor Ownership (Precision Oncology)
NCT04750434	Not specified	COMPLETED	PET MRI as a Staging Tool for Head and Neck Cancer
NCT04905030	Not specified	UNKNOWN	Education, Immigration and HPV Vaccination: an Informational Randomized Trial
NCT05246891	Not specified	COMPLETED	Rehabilitation Nursing Program in Otolaryngology
NCT05549414	Not specified	UNKNOWN	Pivotal Study of Proton Radiotherapy Treatments Using Fixed Beam Chair-Based Delivery System
NCT05746780	Not specified	COMPLETED	Bilateral Elective Neck Dissection in Salvage Total Laryngectomy
NCT06010381	Not specified	COMPLETED	Muscle Energy Technique Versus Maitland Mobilization on Shoulder Pain and Disability
NCT06432998	Not specified	COMPLETED	Perineal Massage in Women With Gynecological Cancer

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
AMIFOSTINE	4	1
CAPECITABINE	4	1
PAFOLACIANINE SODIUM	4	1
PANITUMUMAB	4	1
TECHNETIUM TC 99M TILMANOCEPT	4	1
TILMANOCEPT	4	1
BINTRAFUSP ALFA	3	1
ENTINOSTAT	3	1