Manganese poisoning

Summary

Manganese poisoning (MONDO:0017638) is a disease. A subtype of toxic encephalopathy — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Phenotypes (HPO): 30

Clinical features

Signs & symptoms

Clinical features (HPO)

30 HPO clinical features (Orphanet curated; top 30 by frequency):

HPO ID	Term	Frequency
HP:0000712	Emotional lability	Very frequent (80-99%)
HP:0001276	Hypertonia	Very frequent (80-99%)
HP:0001288	Gait disturbance	Very frequent (80-99%)
HP:0001332	Dystonia	Very frequent (80-99%)
HP:0002067	Bradykinesia	Very frequent (80-99%)
HP:0002071	Abnormality of extrapyramidal motor function	Very frequent (80-99%)
HP:0002172	Postural instability	Very frequent (80-99%)
HP:0002174	Postural tremor	Very frequent (80-99%)
HP:0002315	Headache	Very frequent (80-99%)
HP:0002354	Memory impairment	Very frequent (80-99%)
HP:0002396	Cogwheel rigidity	Very frequent (80-99%)
HP:0002453	Abnormal globus pallidus morphology	Very frequent (80-99%)
HP:0003287	Abnormality of mitochondrial metabolism	Very frequent (80-99%)
HP:0006979	Sleep-wake cycle disturbance	Very frequent (80-99%)
HP:0025464	Increased reactive oxygen species production	Very frequent (80-99%)
HP:0000505	Visual impairment	Frequent (30-79%)
HP:0000718	Aggressive behavior	Frequent (30-79%)
HP:0000722	Compulsive behaviors	Frequent (30-79%)
HP:0000746	Delusion	Frequent (30-79%)
HP:0000748	Inappropriate laughter	Frequent (30-79%)
HP:0000802	Impotence	Frequent (30-79%)
HP:0001289	Confusion	Frequent (30-79%)
HP:0002304	Akinesia	Frequent (30-79%)
HP:0030018	Decreased female libido	Frequent (30-79%)
HP:0040306	Decreased male libido	Frequent (30-79%)
HP:0000716	Depression	Occasional (5-29%)
HP:0000737	Irritability	Occasional (5-29%)
HP:0000738	Hallucinations	Occasional (5-29%)
HP:0031466	Impairment in personality functioning	Occasional (5-29%)
HP:5200321	Amplification of sexual behavior	Occasional (5-29%)

Identifiers

Disease identifiers

Field	Value
Canonical name	manganese poisoning
Mondo ID	MONDO:0017638
EFO	EFO:1001808
MeSH	D020149
Orphanet	306682
SNOMED CT	88687001
GARD	0021264
MedDRA	10058951
Is cancer (heuristic)	no

Also known as: manganese intoxication · Manganism

Disease family

This is a subtype of toxic encephalopathy. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › nervous system disorder › toxic encephalopathy › manganese poisoning

Related subtypes (4): hepatic encephalopathy, carbon monoxide-induced delayed encephalopathy, Minamata disease, chronic bilirubin encephalopathy

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.