Maxillary sinusitis
diseaseOn this page
Summary
Maxillary sinusitis (MONDO:0005842) is a disease and 14 clinical trials. Top therapeutic interventions include levofloxacin anhydrous, ofloxacin, and telithromycin. A subtype of sinusitis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 14
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | maxillary sinusitis |
| Mondo ID | MONDO:0005842 |
| EFO | EFO:0007361 |
| MeSH | D015523 |
| DOID | DOID:2051 |
| NCIT | C34809 |
| SNOMED CT | 88348008 |
| UMLS | C0024959 |
| MedGen | 44313 |
| Is cancer (heuristic) | no |
Disease family
This is a subtype of sinusitis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › otorhinolaryngologic disease › nasal disorder › paranasal sinus disorder › sinusitis › maxillary sinusitis
Related subtypes (4): frontal sinusitis, ethmoid sinusitis, sphenoid sinusitis, chronic rhinosinusitis
Subtypes (2): chronic maxillary sinusitis, acute maxillary sinusitis
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
Drugs indicated for this disease
2 approved, 2 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.
| Drug | Development status |
|---|---|
| Cefuroxime Axetil | Approved (phase 4) |
| Clarithromycin | Approved (phase 4) |
| Azithromycin | Phase 3 (in late-stage trials) |
| Telithromycin | Phase 3 (in late-stage trials) |
Clinical trials & evidence
Clinical trials
Clinical trials: 14.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 8 |
| PHASE3 | 4 |
| PHASE4 | 2 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT00245440 | PHASE4 | TERMINATED | Study to Measure the Impact of Antibiotics on Bacterial Flora in Adults With Acute Sinusitis |
| NCT00668304 | PHASE4 | COMPLETED | Trial to Evaluate Time to Symptom Relief and Elimination of Infecting Bacteria in Treating Sinusitis With Avelox |
| NCT00236652 | PHASE3 | COMPLETED | A Study Evaluating the Safety and Efficacy of Treating Sinus Infection With Levofloxacin 750 mg for 5 Days. |
| NCT00249210 | PHASE3 | COMPLETED | A Study of the Safety and Effectiveness of Levofloxacin Compared With Amoxicillin/Clavulanate Potassium in the Treatment of Adults With Rapid Onset of Severe Inflammation/Infection of the Sinuses |
| NCT00537563 | PHASE3 | COMPLETED | AMS VS MOXI Ketek vs Avelox in AMS |
| NCT00643409 | PHASE3 | COMPLETED | A Multicenter, Randomized, Double-Blind, Double-Dummy Trial of Azithromycin SR Compared With Levofloxacin for the Treatment of Sinus Infections in Adults |
| NCT04645511 | Not specified | RECRUITING | Balloon Sinuplasty Efficiency in Maxillary Rhinosinusitis. |
| NCT06130176 | Not specified | RECRUITING | Single-step Functional Sinus Endoscopy and Transoral Surgery |
| NCT00683371 | Not specified | COMPLETED | Microarray Analysis of Sinus Samples From Patients With and Without Chronic Rhinosinusitis |
| NCT01032174 | Not specified | COMPLETED | Non-Interventional Open Label Prospective Comparative Observational Study Of Evaluation Of Compliance In The Empiric Treatment With Azithromycin SR Versus Amoxiclav 1000 Mg In Adult Patients With Of Acute Bacterial Maxillary Sinusitis |
| NCT02931604 | Not specified | UNKNOWN | Study Designed to Clinically Evaluate Sinus Wash Device Prototypes |
| NCT03083392 | Not specified | UNKNOWN | Endosseous Oroantral Port for Minimal Intervention in Treating Chronic Sinusitis |
| NCT04241016 | Not specified | UNKNOWN | Endoscopic Sinus Surgery in Recurrent Acute Rhinosinusitis |
| NCT04903418 | Not specified | UNKNOWN | Assessment of Relationship Between Maxillary Sinus Floor and Maxillary Posterior Teeth Root Tips Position |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| LEVOFLOXACIN ANHYDROUS | 4 | 6 |
| OFLOXACIN | 4 | 3 |
| TELITHROMYCIN | 4 | 2 |
| AZITHROMYCIN | 4 | 1 |
| CHEMBL1215848 | 0 | 2 |
| CHEMBL4299381 | 0 | 1 |
Related Atlas pages
- Drugs: Levofloxacin, Ofloxacin, Telithromycin, Azithromycin