May-Thurner syndrome
diseaseOn this page
Also known as Cockett syndromecompression syndrome, Iliocavalcompression syndromes, IliocavalIliac vein compression syndromeIliocaval compression syndromeIliocaval compression syndromesMay Thurner syndromesyndrome, Cockettsyndrome, Iliocaval compressionsyndrome, May-Thurnersyndromes, Iliocaval compression
Summary
May-Thurner syndrome (MONDO:0043361) is a disease and 18 clinical trials. Top therapeutic interventions include nadroparin calcium and warfarin. A subtype of peripheral vascular disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 18
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | May-Thurner syndrome |
| Mondo ID | MONDO:0043361 |
| MeSH | D062108 |
| Orphanet | 675404 |
| SNOMED CT | 448804008 |
| UMLS | C3165062 |
| MedGen | 473753 |
| GARD | 0027061 |
| Is cancer (heuristic) | no |
Also known as: Cockett syndrome · compression syndrome, Iliocaval · compression syndromes, Iliocaval · Iliac vein compression syndrome · iliac vein compression syndrome · Iliocaval compression syndrome · Iliocaval compression syndromes · May Thurner syndrome · May-Thurner syndrome · syndrome, Cockett · syndrome, Iliocaval compression · syndrome, May-Thurner · syndromes, Iliocaval compression
Disease family
This is a subtype of peripheral vascular disease. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › cardiovascular disorder › vascular disorder › peripheral vascular disease › May-Thurner syndrome
Related subtypes (10): diabetic peripheral angiopathy, telangiectasis, priapism, intermittent vascular claudication, peripheral arterial disease, mesenteric vascular occlusion, Raynaud disease, thromboangiitis obliterans, erythromelalgia, livedo reticularis
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 18.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 16 |
| PHASE4 | 1 |
| PHASE3 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT02149212 | PHASE4 | COMPLETED | Iliac Vein Stenting in Advanced Chronic Venous Insufficiency |
| NCT04067505 | PHASE3 | UNKNOWN | Rivaroxaban for the Prevention of Deep Vein Thrombosis in Patients With Left Iliac Vein Compression - The PLICTS Study |
| NCT04694248 | Not specified | RECRUITING | Anticoagulant Plus Antiplatelet Therapy Following Iliac Vein Stenting |
| NCT05628948 | Not specified | RECRUITING | Vascular Lab Resource (VLR) Biorepository |
| NCT06888024 | Not specified | RECRUITING | Pelvic Vein Quantitative Flow Characterization Using 2D and 4D Flow MRI |
| NCT01206751 | Not specified | COMPLETED | Multi-detector Computer Tomography Protocol Project: Chest Imaging Technique and Case Presentation |
| NCT01846780 | Not specified | COMPLETED | Treadmill Pilot Study (Invasive Pressure Measurements in PTS) |
| NCT02240914 | Not specified | UNKNOWN | Vascular Ultrasound Versus Intravascular Ultrasound for Diagnosing Iliac Vein Obstruction |
| NCT02584374 | Not specified | UNKNOWN | Balloon Test for Iliac Vein Compression |
| NCT02655887 | Not specified | COMPLETED | BARD® The VENOVO™ Venous Stent Study for Treatment of Iliofemoral Occlusive Disease |
| NCT02942394 | Not specified | COMPLETED | Treatment of the Postthrombotic Syndrome With the Oblique Stent - TOPOS Study |
| NCT03262987 | Not specified | UNKNOWN | Color Doppler U/S vs MSCT Venography in May-Thurner Syndrome |
| NCT03309969 | Not specified | UNKNOWN | Comparison of Intravascular Ultrasound With Venography in the Diagnosis and Treatment of Iliac Vein Compression Syndrome |
| NCT04024215 | Not specified | UNKNOWN | Role of IVUS in Management of Iliocaval Obstruction |
| NCT04580160 | Not specified | COMPLETED | Venous Stent for the Iliofemoral Vein Investigational Clinical Trial Using the DUO Venous Stent System |
| NCT05076448 | Not specified | COMPLETED | The Efficacy and Safety of Interventions on the Pelvic Veins in Pelvic Venous Disorders |
| NCT05409781 | Not specified | WITHDRAWN | Prevalence of May-Thurner Syndrome in 1st-degree Relatives of Symptomatic Patients |
| NCT06180122 | Not specified | COMPLETED | The Use and Reproducibility of Duplex Ultrasound to Provide Indices of Left Common Iliac Vein Diameter |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| NADROPARIN CALCIUM | 4 | 1 |
| WARFARIN | 4 | 1 |
Related Atlas pages
- Drugs: Nadroparin, Warfarin