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Atlas / Disease / Meconium aspiration syndrome

Meconium aspiration syndrome

disease
On this page

Also known as aspiration syndrome, meconiumaspiration, meconiumMASmeconium aspirationmeconium inhalationneonatal aspiration of meconiumsyndrome, meconium aspiration

Summary

Meconium aspiration syndrome (MONDO:0006851) is a disease and 19 clinical trials. Top therapeutic interventions include sildenafil, caffeine citrate, and emapalumab. A subtype of neonatal aspiration syndrome — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

  • Prevalence: 1-9 / 100 000 (Europe) [Orphanet-validated]
  • Phenotypes (HPO): 22
  • Clinical trials: 19

Clinical features

Epidemiology

Prevalence records

1 prevalence record(s), Orphanet:

TypeClassValueGeographyValidation
Point prevalence1-9 / 100 0002.44EuropeValidated

Signs & symptoms

Clinical features (HPO)

22 HPO clinical features (Orphanet curated; top 22 by frequency):

HPO IDTermFrequency
HP:0002098Respiratory distressFrequent (30-79%)
HP:0005828Transient pulmonary infiltratesFrequent (30-79%)
HP:0011410Caesarian sectionFrequent (30-79%)
HP:0025116Fetal distressFrequent (30-79%)
HP:0031169Postterm pregnancyFrequent (30-79%)
HP:0031860Abnormal heart rate variabilityFrequent (30-79%)
HP:0031983Abnormal pulmonary thoracic imaging findingFrequent (30-79%)
HP:0001511Intrauterine growth retardationOccasional (5-29%)
HP:0001788Premature rupture of membranesOccasional (5-29%)
HP:0002092Pulmonary arterial hypertensionOccasional (5-29%)
HP:0002107PneumothoraxOccasional (5-29%)
HP:0008071Maternal hypertensionOccasional (5-29%)
HP:0009800Maternal diabetesOccasional (5-29%)
HP:0011951Aspiration pneumoniaOccasional (5-29%)
HP:0012418HypoxemiaOccasional (5-29%)
HP:0012420Meconium stained amniotic fluidOccasional (5-29%)
HP:0012768Neonatal asphyxiaOccasional (5-29%)
HP:0025421PneumomediastinumOccasional (5-29%)
HP:0030828WheezingOccasional (5-29%)
HP:0100750AtelectasisOccasional (5-29%)
HP:0001298EncephalopathyVery rare (<1-4%)
HP:0010444Pulmonary insufficiencyVery rare (<1-4%)

Identifiers

Disease identifiers

FieldValue
Canonical namemeconium aspiration syndrome
Mondo IDMONDO:0006851
EFOEFO:1001037
MeSHD008471
Orphanet70588
DOIDDOID:11049
ICD-10-CMP24.0
ICD-11872221482
NCITC87093
SNOMED CT206292002
UMLSC0025048
MedGen6258
GARD0010494
MedDRA10027057
Is cancer (heuristic)no

Also known as: aspiration syndrome, meconium · aspiration, meconium · MAS · meconium aspiration · meconium aspiration syndrome · meconium inhalation · neonatal aspiration of meconium · syndrome, meconium aspiration

Disease family

This is a subtype of neonatal aspiration syndrome. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › syndromic disease › neonatal aspiration syndrome › meconium aspiration syndrome

Related subtypes (1): massive neonatal aspiration syndrome

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

0 approved, 1 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.

DrugDevelopment status
LucinactantPhase 3 (in late-stage trials)

Clinical trials & evidence

Clinical trials

Clinical trials: 19.

Phase distribution (across all retrieved trials)

PhaseTrials
Not specified13
PHASE33
PHASE42
PHASE21

Top trials by phase / activity

NCTPhaseStatusTitle
NCT01757782PHASE4COMPLETEDOral Sildenafil in Persistent Pulmonary Hypertension Secondary to Meconium Aspiration Syndrome in Newborns
NCT02041546PHASE4COMPLETEDLung Lavage With Dilute Poractant Alfa for Meconium Aspiration Syndrome
NCT00004500PHASE3TERMINATEDPhase III Randomized Study of Lucinactant in Full Term Newborn Infants With Meconium Aspiration Syndrome
NCT00312507PHASE3UNKNOWNSurfactant Lavage vs. Bolus Surfactant in Neonates With Meconium Aspiration
NCT05001737PHASE3COMPLETEDEvaluate Efficacy, Safety and Tolerability, PK and PD of Emapalumab in Children and Adults With MAS in Still’s or SLE
NCT06972108PHASE2NOT_YET_RECRUITINGCAffeine Use in Prolonged Oxygen Use in meConium aspIration Syndrome in Neonatal Outcomes (CAPUCINO)
NCT03346343Not specifiedACTIVE_NOT_RECRUITINGPulmonary Function Using Non-invasive Forced Oscillometry
NCT07344714Not specifiedRECRUITINGPredicting the Need for Prolonged Respiratory Support in Neonates Delivered in a Lower-Level NICU Setting
NCT00371241Not specifiedCOMPLETEDAntibody Secreting Cell and Cyotokine Profiles in Neonates on ECMO
NCT01274845Not specifiedCOMPLETEDUse of Heliox in the Management of Neonates With Meconium Aspiration Syndrome
NCT01310621Not specifiedCOMPLETEDComparison Of Surfactant Lung Lavage With Standard Care In The Treatment Of Meconium Aspiration Syndrome
NCT01328483Not specifiedCOMPLETEDEffect Of Intrapartum Oropharyngeal (IP-OP) Suction on Meconium Aspiration Syndrome
NCT01758822Not specifiedCOMPLETEDRole of Endotracheal Suction on the Occurrence of Meconium Aspiration Syndrome in Non-vigorous Meconium Stained Babies
NCT02571231Not specifiedUNKNOWNHigh Flow Ventilation With Volume Guarantee
NCT02708563Not specifiedWITHDRAWNMeconium Aspiration and Tracheal Suctioning-Feasibility Study
NCT03996317Not specifiedWITHDRAWNMaternal Hyperoxygenation for Intrapartum Fetal Heart Rate Tracing Abnormalities
NCT04076189Not specifiedCOMPLETEDTime of Positive Pressure Ventilation in Non-vigorous Infants Born Through Meconium-stained Amniotic Fluid
NCT06090981Not specifiedCOMPLETEDEarly Bolus Surfactant Replacement Therapy Versus Standard Care in Term Neonates With Meconium Aspiration Syndrome
NCT07394322Not specifiedCOMPLETEDInterleukin-6 in the Development of Meconium Aspiration Syndrome in Newborn

Drugs tested across these trials (top 30)

MoleculeMax phaseTrials referencing
SILDENAFIL43
CAFFEINE CITRATE41
EMAPALUMAB41
LUCINACTANT41

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.2
BioBTree
v2.0.2

Sources 24

This page pulls from 24 datasets indexed by BioBTree:

chembl_moleculecivic_evidenceclinical_trialsclinvardoidefogardgenccgwasgwas_studyhgncicd10cmicd11meddramedgenmeshmimmondomondochildmondoparentncitorphanetsctidumls