Medial condensing osteitis of the clavicle

Summary

Medial condensing osteitis of the clavicle (MONDO:0018929) is a disease. A subtype of osteochondrosis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: <1 / 1 000 000 (Worldwide) [Orphanet-validated]
• Phenotypes (HPO): 5

Clinical features

Epidemiology

Prevalence records

2 prevalence record(s), Orphanet:

Type	Class	Value	Geography	Validation
Cases/families		58	Worldwide	Validated
Point prevalence	<1 / 1 000 000		Worldwide	Validated

Signs & symptoms

Clinical features (HPO)

5 HPO clinical features (Orphanet curated; top 5 by frequency):

HPO ID	Term	Frequency
HP:0000889	Abnormality of the clavicle	Frequent (30-79%)
HP:0010657	Patchy reduction of bone mineral density	Frequent (30-79%)
HP:0030834	Shoulder pain	Frequent (30-79%)
HP:0006467	Limited shoulder movement	Occasional (5-29%)
HP:0011227	Elevated circulating C-reactive protein concentration	Occasional (5-29%)

Identifiers

Disease identifiers

Field	Value
Canonical name	medial condensing osteitis of the clavicle
Mondo ID	MONDO:0018929
Orphanet	57196
UMLS	C5396729
MedGen	1710994
GARD	0010910
Is cancer (heuristic)	no

Also known as: condensing osteitis of the clavicle · condensing osteitis of the medial clavicle · osteitis condensans of the clavicle

Disease family

This is a subtype of osteochondrosis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › skeletal system disorder › bone disorder › osteonecrosis › osteochondrosis › medial condensing osteitis of the clavicle

Related subtypes (10): Osgood-Schlatter disease, Legg-Calve-Perthes disease, Thiemann disease, familial form, Scheuermann disease, dihydropyrimidine dehydrogenase deficiency, osteochondritis of tarsal/metatarsal bone, Kienbock disease, panner disease, Sinding-Larsen-Johansson disease, Freiberg disease

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.