Mediastinal cancer

Summary

Mediastinal cancer (MONDO:0005843) is a cancer (an umbrella term covering 6 Mondo subtypes) and 10 clinical trials. Top therapeutic interventions include bleomycin sulfate, cisplatin, and etoposide. A subtype of thoracic cancer — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer
• Umbrella term: 6 Mondo subtypes
• Clinical trials: 10

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	mediastinal cancer
Mondo ID	MONDO:0005843
EFO	EFO:0007362
MeSH	D008479
DOID	DOID:5559
NCIT	C3549
SNOMED CT	363494000
UMLS	C0153504
MedGen	56308
Anatomy (UBERON)	UBERON:0003728
Is cancer (heuristic)	yes

Also known as: cancer of mediastinum · cancer of the mediastinum · malignant mediastinal neoplasm · malignant mediastinal tumor · malignant mediastinal tumour · malignant mediastinum neoplasm · malignant neoplasm of mediastinum · malignant neoplasm of the mediastinum · malignant tumor of mediastinum · malignant tumor of the mediastinum · malignant tumour of mediastinum · malignant tumour of the mediastinum · mediastinal cancer · mediastinal tumor · mediastinal tumour · mediastinum cancer · tumor of mediastinum · tumour of mediastinum

Disease family

This is a subtype of thoracic cancer. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › cancer › thoracic cancer › mediastinal cancer

Related subtypes (7): heart cancer, sternum cancer, Askin tumor, pleural cancer, breast cancer, lung cancer, malignant neoplasm of chest wall

Subtypes (6): mediastinum neuroblastoma, posterior mediastinum cancer, mediastinal malignant lymphoma, mediastinal malignant germ cell tumor, malignant mediastinal neural neoplasm, mediastinal soft tissue cancer

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated or in trials for this disease

3 approved drugs — disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.

Drug	Status
Cisplatin	Approved (phase 3)
Etoposide	Approved (phase 3)
Ifosfamide	Approved (phase 3)

2 drugs in clinical trials for this disease (phase 2–3, investigational): efficacy not established — a trial record, not an indication.

Drug	Highest phase
Filgrastim	Phase 3
Topotecan	Phase 2

Clinical trials & evidence

Clinical trials

Clinical trials: 10.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	7
PHASE3	2
PHASE2	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00003941	PHASE3	COMPLETED	Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Men With Previously Untreated Germ Cell Cancer
NCT05369234	PHASE3	COMPLETED	Effects of Oral Aloe Vera Juice on Chemotherapy and Radiation-induced Oral Mucositis and Esophagitis
NCT05163509	PHASE2	UNKNOWN	MR-linac Guided Adaptive Radiotherapy for Inoperable Mediastinal Tumor
NCT05267496	Not specified	ACTIVE_NOT_RECRUITING	Oscillating Positive Expiratory Pressure Therapy for Patients With Thoracic Neoplasms Undergoing Chest Surgery
NCT05682742	Not specified	ACTIVE_NOT_RECRUITING	Clinical Investigation of the da Vinci Surgical System
NCT02220231	Not specified	COMPLETED	Echocardiographic Evaluation of the Change on Pulmonary Blood Flow and Cardiac Function Induced by Capnothorax During One Lung Ventilation
NCT03214341	Not specified	UNKNOWN	Assessment of Mediastinal Masses With Diffusion Weighted MR Imaging
NCT03439696	Not specified	COMPLETED	Needlescopic-assisted Uniportal vs Uniportal VATS
NCT03537430	Not specified	COMPLETED	Totally no Tube (TNT) Uniportal Video-assisted Thoracoscopic Surgery (VATS) VS Traditional Uniportal VATS for Mediastinal Tumor
NCT03613272	Not specified	UNKNOWN	The Curative Effect of Extended Thymectomy Performed Through Subxiphoid-right VATS Approach With Elevation of Sternum

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
BLEOMYCIN SULFATE	4	1
CISPLATIN	4	1
ETOPOSIDE	4	1
FILGRASTIM	4	1
IFOSFAMIDE	4	1
SUCRALFATE	4	1