Mediastinal malignant germ cell tumor

Summary

Mediastinal malignant germ cell tumor (MONDO:0006298) is a cancer. A subtype of extragonadal germ cell cancer — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	mediastinal malignant germ cell tumor
Mondo ID	MONDO:0006298
EFO	EFO:1000366
NCIT	C6446
SNOMED CT	713293002
UMLS	C1334597
MedGen	277334
GARD	0024365
Is cancer (heuristic)	yes

Also known as: malignant germ cell tumour of mediastinum · malignant germ cell tumour of the mediastinum · malignant mediastinal germ cell tumor · malignant mediastinal germ cell tumour · mediastinal germ cell tumor, malignant · mediastinal malignant germ cell tumor · thymic malignant germ cell tumor · thymic malignant germ cell tumour

Disease family

An umbrella term covering 3 Mondo subtypes.

Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › cancer › malignant germ cell tumor › extragonadal germ cell cancer › mediastinal malignant germ cell tumor

Related subtypes (8): mixed extragonadal germ cell cancer, malignant cardiac germ cell tumor, malignant pineal area germ cell neoplasm, malignant gastric germ cell tumor, extragonadal nonseminomatous germ cell tumor, extragonadal seminoma, extragonadal germinoma, malignant peritoneal germ cell tumor

Subtypes (3): mediastinum seminoma, malignant teratoma of mediastinum, mediastinal yolk sac tumor

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.