Mediastinitis

Summary

Mediastinitis (MONDO:0004492) is a disease and 16 clinical trials. Top therapeutic interventions include delafloxacin. A subtype of inflammatory disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 16

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	mediastinitis
Mondo ID	MONDO:0004492
MeSH	D008480
DOID	DOID:819
ICD-10-CM	J98.51
ICD-11	1612791605
NCIT	C26827
SNOMED CT	47597000
UMLS	C0025064
MedGen	9921
Anatomy (UBERON)	UBERON:0003728
Is cancer (heuristic)	no

Disease family

This is a subtype of inflammatory disease. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by developmental or physiological process › inflammatory disease › mediastinitis

Related subtypes (93): chorioamnionitis, pyometritis, uvulitis, mastoiditis, pelvic inflammatory disease, tonsillitis, nasopharyngitis, petrositis, nephritis, esophagitis, geniculate ganglionitis, epicondylitis, labyrinthitis, lymphadenitis, cheilitis, neuritis, vaginitis, hepatitis, pharyngitis, hidradenitis, gastroenteritis, dermatitis, bursitis, laryngitis, keratitis, endocervicitis, conjunctivitis, spondylitis, thyroiditis, diverticulitis, neuronitis, epididymitis, blepharitis, cholangitis, dacryoadenitis, fasciitis, chronic inflammation of lacrimal passage, dacryocystitis, periostitis, gastritis, pancreatitis, periodontitis, encephalomyelitis, placental villitis, prostatitis, urethritis, otitis media, perianal Crohn disease, proctitis, arthritic joint disease, oral tuberculosis, parotitis, pericarditis, sinusitis, cystitis, panniculitis, balanitis, chronic inflammatory demyelinating polyradiculoneuropathy, glossitis, mastitis, oophoritis, orchitis, perinephritis, pulpitis, rheumatic heart disease, vulvitis, thromboangiitis obliterans, STING-associated vasculopathy with onset in infancy, endophthalmitis, chronic granulomatous disease, IgG4-related pachymeningitis, vasculitis, chronic pneumonitis of infancy, uveitis, mucositis, amnionitis, diaphragmitis, gonococcal cervicitis, posthitis, myositis disease, omphalitis, ear infection, radiculitis, tracheobronchitis, ureteritis, enthesitis, inflammation of heart layer, serositis, pneumonitis, immune reconstitution inflammatory syndrome, multiple evanescent white dot syndrome, isolated anogenital granulomatosis, myelin oligodendrocyte glycoprotein antibody-associated disease

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 16.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	13
PHASE4	2
PHASE2/PHASE3	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT07507409	PHASE4	NOT_YET_RECRUITING	Innovative Sternal Closure Techniques: Evaluating STRATAFIX™ and DERMABOND™ for Reduced Complications in CABG Patients
NCT00638014	PHASE4	COMPLETED	Rapid Sternal Closure System (TALON)
NCT00518687	PHASE2/PHASE3	TERMINATED	Efficacy, Immunogenicity, and Safety of a Single Dose of V710 in Adult Patients Scheduled for Cardiothoracic Surgery (V710-003 AM2)
NCT07376070	Not specified	ACTIVE_NOT_RECRUITING	The Role of Inflammatory Biomarkers in Preventing Deep Sternal Wound Infections After Sternotomy
NCT07426471	Not specified	NOT_YET_RECRUITING	Delafloxacin Plasma and Tissue Concentration in Patients With Skin, Soft Tissue, and Bone and Joint Infections.
NCT00819286	Not specified	COMPLETED	Evaluation of Primary Plating in Sternotomy Patients for Osteosynthesis and Pain
NCT00876551	Not specified	UNKNOWN	Endoscopic-vacuum Assisted Closure of Intrathoracic Postsurgical Leaks
NCT01473979	Not specified	UNKNOWN	Delayed Primary Versus Late Secondary Wound Closure in Sternum Infections
NCT02073760	Not specified	COMPLETED	Optimizing Prevention of Healthcare-Acquired Infections After Cardiac Surgery (HAI)_2
NCT02513576	Not specified	COMPLETED	Physiotherapy Exercises in Patients With Sternal Instability After Cardiovascular Surgery
NCT03922191	Not specified	COMPLETED	Post-Surgical Mediastinitis Within the CHU Brugmann Hospital
NCT03961503	Not specified	COMPLETED	Retrospective Analysis of Nephrotoxicity During Daptomycin Versus Vancomycin Treatments in High Risk Patients
NCT04617353	Not specified	COMPLETED	Combined Air-plasma Flow and Nitric Oxide Therapy in Cardiac Surgery
NCT04865003	Not specified	COMPLETED	Prognostic Factors for Descending Necrotizing Mediastinitis Development in Deep Space Neck Infections
NCT05001308	Not specified	UNKNOWN	Infectious Mediastinitis Among the Strasbourg Universitary Hospital
NCT07352020	Not specified	COMPLETED	Use of Platelet-Rich Plasma to Reduce Sternal Wound Complications After CABG With Median Sternotomy

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
DELAFLOXACIN	4	1