Mediastinum sarcoma

Summary

Mediastinum sarcoma (MONDO:0002852) is a cancer (an umbrella term covering 7 Mondo subtypes). A subtype of soft tissue sarcoma — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer
• Umbrella term: 7 Mondo subtypes

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	mediastinum sarcoma
Mondo ID	MONDO:0002852
DOID	DOID:4050
NCIT	C6606
UMLS	C1334678
MedGen	233687
GARD	0023270
Anatomy (UBERON)	UBERON:0003728
Is cancer (heuristic)	yes

Also known as: mediastinal sarcoma · mediastinum sarcoma · sarcoma of mediastinum · sarcoma of the mediastinum

Disease family

This is a subtype of soft tissue sarcoma. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › cancer › sarcoma › soft tissue sarcoma › mediastinum sarcoma

Related subtypes (45): esophagus sarcoma, bladder sarcoma, penile sarcoma, trachea sarcoma, retroperitoneal sarcoma, paranasal sinus sarcoma, pancreas sarcoma, vagina sarcoma, undifferentiated pleomorphic sarcoma, central nervous system sarcoma, ovarian sarcoma, liver sarcoma, lung sarcoma, laryngeal sarcoma, breast sarcoma, extraosseous osteosarcoma, rhabdoid tumor, prostate sarcoma, gallbladder sarcoma, testis sarcoma, anus sarcoma, clear cell sarcoma, kidney sarcoma, thyroid sarcoma, heart sarcoma, small intestinal sarcoma, leiomyosarcoma, liposarcoma, fibrosarcoma, rhabdomyosarcoma, vulva sarcoma, intimal sarcoma, skin sarcoma, myxosarcoma, synovial sarcoma, alveolar soft part sarcoma, extraskeletal myxoid chondrosarcoma, angiosarcoma, epithelioid sarcoma, extraskeletal Ewing sarcoma, SMARCA4-deficient sarcoma of thorax, myxofibrosarcoma, desmoplastic small round cell tumor, undifferentiated round cell sarcoma, stromal sarcoma

Subtypes (7): mediastinum rhabdomyosarcoma, mediastinum angiosarcoma, mediastinum leiomyosarcoma, mediastinum synovial sarcoma, mediastinum liposarcoma, mediastinal extraskeletal osteosarcoma, malignant melanocytic peripheral nerve sheath tumor of mediastinum

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.