Melanocytic nevus
disease diseaseOn this page
Also known as melanotic Nevusmolemole of skinnevus
Summary
Melanocytic nevus (MONDO:0005073) is a disease (an umbrella term covering 28 Mondo subtypes) and 26 clinical trials. Top therapeutic interventions include lidocaine and avotermin. A subtype of benign neoplasm of skin — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Umbrella term: 28 Mondo subtypes
- Clinical trials: 26
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | melanocytic nevus |
| Mondo ID | MONDO:0005073 |
| EFO | EFO:0009675 |
| MeSH | D009506 |
| NCIT | C7570 |
| SNOMED CT | 400096001 |
| UMLS | C0027962 |
| MedGen | 14364 |
| Anatomy (UBERON) | UBERON:0000014 |
| Is cancer (heuristic) | no |
Also known as: melanocytic Nevus · melanotic Nevus · mole · mole of skin · nevus
Disease family
This is a subtype of benign neoplasm of skin. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › integumentary system disorder › integumentary system benign neoplasm › benign neoplasm of skin › melanocytic nevus
Related subtypes (11): bacillary angiomatosis, skin lipoma, skin hemangioma, leiomyoma cutis, encephalocraniocutaneous lipomatosis, familial multiple fibrofolliculoma, benign neoplasm of sweat gland, benign neoplasm of sebaceous gland, benign eyelid neoplasm, benign epithelial skin neoplasm, skin lymphangioma
Subtypes (28): conjunctival nevus, blue nevus, halo nevus, intradermal nevus, pigmented spindle cell nevus, nevus, epidermal, neurocutaneous melanocytosis, neutrophil actin dysfunction, CHILD syndrome, Becker nevus syndrome, CLOVES syndrome, nevus comedonicus syndrome, segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome, congenital panfollicular nevus, porokeratotic eccrine ostial and dermal duct nevus, hereditary mucosal leukokeratosis, linear verrucous nevus syndrome, nevus of Ota, nevus of Ito, phakomatosis pigmentokeratotica, PENS syndrome, Angora hair nevus, didymosis aplasticosebacea, scalp syndrome, Nevada syndrome, palpebral nevus, large congenital melanocytic nevus, benign melanocytic skin nevus
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 26.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 23 |
| PHASE2 | 1 |
| PHASE1/PHASE2 | 1 |
| PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT00656227 | PHASE2 | UNKNOWN | A Trial to Investigate Scar Improvement Efficacy of RN1001 (Avotermin) After Head and Neck Naevi Excision |
| NCT02809001 | PHASE1/PHASE2 | COMPLETED | The Effects of Autologous Fat Transfer on Preventing Expanded Skin From Expansion Failure |
| NCT05418959 | PHASE1 | ENROLLING_BY_INVITATION | Genetic Risk Stratification of Pediatric Skin Lesions |
| NCT05446155 | Not specified | RECRUITING | BioMEL- Diagnostic and Prognostic Factors in Melanoma. |
| NCT07349940 | Not specified | RECRUITING | Early Detection of Skin Tumors Using a Telemedicine Tool in Primary Care |
| NCT00005781 | Not specified | COMPLETED | Assessment of Digital Imaging as a Tool for Diagnosing Psoriasis, Hand Rashes and Unusual Moles |
| NCT00287001 | Not specified | COMPLETED | Effect of Cold Air Cooling on the Incidence of Post Inflammatory Hyperpigmentation Following Laser Treatment |
| NCT00487864 | Not specified | COMPLETED | In Vivo Confocal Scanning Laser Microscopy of Benign Nevi |
| NCT01324609 | Not specified | TERMINATED | Detection of Choroidal Nevus Cells in Vitrectomy Fluid |
| NCT01993654 | Not specified | TERMINATED | In Vivo Confocal Microscopy Study of Pigmented Conjunctival Lesions |
| NCT02012751 | Not specified | COMPLETED | Nevus Doctor Clinical Decision Support |
| NCT02425475 | Not specified | COMPLETED | FLuorescence Identification of Melanoma by a Multicenter Based Algorithm (FLIMMA) |
| NCT02473874 | Not specified | WITHDRAWN | Comparison Imaging System Between Spatially Modulated Quantitative Spectroscopy and Skin Spect Dermoscopy |
| NCT03109327 | Not specified | COMPLETED | Investigating the Clinical Utility of the MDS |
| NCT03535077 | Not specified | COMPLETED | Assessing Tissue Remodeling in the Skin Using SFI (Skin Fluorescence Imaging) |
| NCT03699995 | Not specified | TERMINATED | MoleMapper, Visiomed, and Confocal Microscopy in Screening Participants for Melanoma |
| NCT04353050 | Not specified | UNKNOWN | Atypical MOLes and Melanoma Early Detection Study (MoleMed) |
| NCT04368247 | Not specified | COMPLETED | Skin Fluorescent Imaging (SFI) System in Patients With Nevi |
| NCT04406454 | Not specified | COMPLETED | The Application of Non-invasive and Cellular Level Resolution Fullfield Optical Coherence Tomography: Establishment and Analysis of Subcutaneous Cellular Level Image Database of Anatomical Locations in Healthy Volunteers and Evaluation of Usability |
| NCT04550000 | Not specified | COMPLETED | Sample Collection Study in Patients With Suspected Melanoma Utilizing DermTech’s Non-invasive Adhesive Patch Biopsy Kits |
| NCT04705168 | Not specified | COMPLETED | Study of the Nevisense Device to Assess Atypical Skin Lesions |
| NCT05402046 | Not specified | UNKNOWN | Clinical vAlidation of a MobilE appLication (ProRodinki) in the Assessment of the maLignant skIn neoplAsms |
| NCT06046144 | Not specified | COMPLETED | Comparison of 3 in Vivo Microscopic Imaging Techniques for the Diagnosis of Pigmented Tumors |
| NCT07384299 | Not specified | COMPLETED | Impact of Skin Type on Wonud Healing and Scarring Following Facial Skin Surgery |
| NCT07428954 | Not specified | COMPLETED | Using Artificial Intelligence to Help Doctors Identify Different Skin Conditions and Improve Patient Care |
| NCT07441538 | Not specified | COMPLETED | Optimizing the Timing for Facial Surgical Dressing Removal |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| LIDOCAINE | 4 | 1 |
| AVOTERMIN | 3 | 1 |