Melioidosis
disease diseaseOn this page
Also known as B pseudomallei infectionBurkholderia pseudomallei caused disease or disorderBurkholderia pseudomallei disease or disorderBurkholderia pseudomallei infectionBurkholderia pseudomallei infectious diseasepseudoglandersWhitmore disease
Summary
Melioidosis (MONDO:0017775) is a disease and 12 clinical trials. Top therapeutic interventions include ceftazidime, meropenem, and co-trimoxazole. A subtype of primary bacterial infectious disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Prevalence: 1-5 / 10 000 (Australia) [Orphanet-validated]
- Phenotypes (HPO): 23
- Clinical trials: 12
Clinical features
Epidemiology
Prevalence records
2 prevalence record(s), Orphanet:
| Type | Class | Value | Geography | Validation |
|---|---|---|---|---|
| Annual incidence | 1-5 / 10 000 | 50 | Australia | Validated |
| Annual incidence | 1-5 / 10 000 | 50 | Thailand | Validated |
Signs & symptoms
Clinical features (HPO)
23 HPO clinical features (Orphanet curated; top 23 by frequency):
| HPO ID | Term | Frequency |
|---|---|---|
| HP:0001945 | Fever | Frequent (30-79%) |
| HP:0002090 | Pneumonia | Frequent (30-79%) |
| HP:0011947 | Respiratory tract infection | Frequent (30-79%) |
| HP:0011949 | Acute infectious pneumonia | Frequent (30-79%) |
| HP:0025044 | Lung abscess | Frequent (30-79%) |
| HP:0031273 | Shock | Frequent (30-79%) |
| HP:0031864 | Bacteremia | Frequent (30-79%) |
| HP:0100806 | Sepsis | Frequent (30-79%) |
| HP:0001743 | Abnormality of the spleen | Occasional (5-29%) |
| HP:0002758 | Osteoarthritis | Occasional (5-29%) |
| HP:0003095 | Septic arthritis | Occasional (5-29%) |
| HP:0012115 | Hepatitis | Occasional (5-29%) |
| HP:0025059 | Splenic abscess | Occasional (5-29%) |
| HP:0030049 | Brain abscess | Occasional (5-29%) |
| HP:0031292 | Cutaneous abscess | Occasional (5-29%) |
| HP:0032162 | Unusual skin infection | Occasional (5-29%) |
| HP:0100523 | Liver abscess | Occasional (5-29%) |
| HP:0100658 | Cellulitis | Occasional (5-29%) |
| HP:0000024 | Prostatitis | Very rare (<1-4%) |
| HP:0000119 | Abnormality of the genitourinary system | Very rare (<1-4%) |
| HP:0000197 | Abnormal parotid gland morphology | Very rare (<1-4%) |
| HP:0001886 | Foot osteomyelitis | Very rare (<1-4%) |
| HP:0011850 | Parotitis | Very rare (<1-4%) |
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | melioidosis |
| Mondo ID | MONDO:0017775 |
| MeSH | D008554 |
| Orphanet | 31202 |
| DOID | DOID:5052 |
| ICD-11 | 2129350166 |
| NCIT | C128336 |
| SNOMED CT | 186312003 |
| UMLS | C0025229 |
| MedGen | 44346 |
| GARD | 0009546 |
| MedDRA | 10069748 |
| Is cancer (heuristic) | no |
Also known as: B pseudomallei infection · Burkholderia pseudomallei caused disease or disorder · Burkholderia pseudomallei disease or disorder · Burkholderia pseudomallei infection · Burkholderia pseudomallei infectious disease · pseudoglanders · Whitmore disease
Disease family
This is a subtype of primary bacterial infectious disease. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › infectious disease › bacterial infectious disease › primary bacterial infectious disease › melioidosis
Related subtypes (36): Buruli ulcer disease, sennetsu fever, salmonellosis, pinta disease, chancroid, gonorrhea, anthrax infection, leprosy, botulism, diphtheria, tetanus, bartonellosis, brucellosis, campylobacteriosis, glanders, granuloma inguinale, legionellosis, leptospirosis, listeriosis, Mycobacterium avium complex disease, ornithosis, rhinoscleroma, staphyloenterotoxemia, syphilis, cholera, ehrlichiosis, tuberculosis, tularemia, plague, Q fever, shigellosis, Lyme disease, relapsing fever, spirillary rat-bite fever, streptobacillary rat-bite fever, Borrelia miyamotoi disease
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 12.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 10 |
| PHASE4 | 1 |
| PHASE2 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT01420341 | PHASE4 | COMPLETED | Co-trimoxazole as Maintenance Therapy for Melioidosis |
| NCT05105035 | PHASE2 | COMPLETED | Oral ARV-1801 Given in Combination With Intravenous Ceftazidime or Meropenem for Treatment of Melioidosis in Hospitalized Patients |
| NCT07345910 | Not specified | NOT_YET_RECRUITING | Environment, Pathogens, and Host Interactions in Melioidosis |
| NCT07358910 | Not specified | RECRUITING | Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective |
| NCT00579956 | Not specified | UNKNOWN | A Randomized Double Blinded Comparison of Ceftazidime and Meropenem in Severe Melioidosis |
| NCT01766830 | Not specified | COMPLETED | Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever) |
| NCT02089152 | Not specified | COMPLETED | A Single-blind Stepped Wedge Cluster Randomized Controlled Behaviour Change Trial to Determine Effectiveness of Prevention Programme of Melioidosis in Diabetics in Ubon Ratchathani, Northeast Thailand |
| NCT02668406 | Not specified | COMPLETED | Study to Obtain Blood and Voided Urine Samples to Improve the Diagnosis of Melioidosis |
| NCT03048513 | Not specified | UNKNOWN | Clinical Presentation of Melioidosis in Head and Neck Region |
| NCT03528265 | Not specified | COMPLETED | Adapting LFI for Melioidosis |
| NCT04299412 | Not specified | COMPLETED | Diagnostic Accuracy of the DPP II Assay |
| NCT06089668 | Not specified | COMPLETED | An Observational Study to Evaluate Clinical Characteristics of Adult Patients With Suspected or Confirmed Melioidosis |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| CEFTAZIDIME | 4 | 1 |
| MEROPENEM | 4 | 1 |
| CO-TRIMOXAZOLE | 3 | 1 |
| CHEMBL4740200 | 0 | 1 |
Related Atlas pages
- Drugs: Ceftazidime, Meropenem, Co-Trimoxazole