Methanol poisoning

Summary

Methanol poisoning (MONDO:0017860) is a disease and 4 clinical trials. A subtype of poisoning — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: Unknown (Worldwide)
• Phenotypes (HPO): 29
• Clinical trials: 4

Clinical features

Signs & symptoms

Clinical features (HPO)

29 HPO clinical features (Orphanet curated; top 29 by frequency):

HPO ID	Term	Frequency
HP:0001942	Metabolic acidosis	Very frequent (80-99%)
HP:0000505	Visual impairment	Frequent (30-79%)
HP:0000622	Blurred vision	Frequent (30-79%)
HP:0000822	Hypertension	Frequent (30-79%)
HP:0002170	Intracranial hemorrhage	Frequent (30-79%)
HP:0003077	Hyperlipidemia	Frequent (30-79%)
HP:0030955	Alcoholism	Frequent (30-79%)
HP:0031982	Abnormal putamen morphology	Frequent (30-79%)
HP:0000587	Abnormal optic nerve morphology	Occasional (5-29%)
HP:0000618	Blindness	Occasional (5-29%)
HP:0001259	Coma	Occasional (5-29%)
HP:0001273	Abnormal corpus callosum morphology	Occasional (5-29%)
HP:0001289	Confusion	Occasional (5-29%)
HP:0001658	Myocardial infarction	Occasional (5-29%)
HP:0002013	Vomiting	Occasional (5-29%)
HP:0002014	Diarrhea	Occasional (5-29%)
HP:0002027	Abdominal pain	Occasional (5-29%)
HP:0002453	Abnormal globus pallidus morphology	Occasional (5-29%)
HP:0002500	Abnormal cerebral white matter morphology	Occasional (5-29%)
HP:0005978	Type II diabetes mellitus	Occasional (5-29%)
HP:0007146	Bilateral basal ganglia lesions	Occasional (5-29%)
HP:0012128	Basal ganglia necrosis	Occasional (5-29%)
HP:0001250	Seizure	Very rare (<1-4%)
HP:0001342	Cerebral hemorrhage	Very rare (<1-4%)
HP:0002339	Abnormal caudate nucleus morphology	Very rare (<1-4%)
HP:0004754	Permanent atrial fibrillation	Very rare (<1-4%)
HP:0005291	Inflammatory arteriopathy	Very rare (<1-4%)
HP:0031422	Abnormal morphology of the cerebellar cortex	Very rare (<1-4%)
HP:0100651	Type I diabetes mellitus	Very rare (<1-4%)

Identifiers

Disease identifiers

Field	Value
Canonical name	methanol poisoning
Mondo ID	MONDO:0017860
Orphanet	31825
GARD	0018804
Is cancer (heuristic)	no

Disease family

This is a subtype of poisoning. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › poisoning › methanol poisoning

Related subtypes (58): toxic oil syndrome, infantile mercury poisoning, ketamine-induced biliary dilatation, manganese poisoning, cyanide-induced parkinsonism, colchicine poisoning, ethylene glycol poisoning, paraquat poisoning, lead poisoning, mercury poisoning, acute opioid poisoning, acute tricyclic antidepressant poisoning, acute poisoning by drugs with membrane-stabilizing effect, snakebite envenomation, paracetamol poisoning, cyanide poisoning, scorpion envenomation, argyria, acute ackee fruit intoxication, cocaine intoxication, systemic monochloroacetate poisoning, water intoxication, cassavism, formaldehyde poisoning, heavy metal poisoning, abacavir toxicity, allopurinol toxicity, codeine toxicity, efavirenz toxicity, flucloxacilline toxicity, isoniazid toxicity, raltegravir toxicity, voriconazole toxicity, curariform drugs toxicity, statin toxicity, phenytoin or carbamazepine toxicity, letrozole toxicity, ricin poisoning, ivermectin toxicity, belinostat toxicity or dose selection, toxicity to dolutegravir, mycotoxicosis, ciguatera fish poisoning, lathyrism, cadmium poisoning, phenytoin toxicity, nerve agent poisoning, local anesthetic poisoning, fire ant poisoning, aflatoxicosis, black widow spider envenomation, platinum-induced ototoxicity, carbon monoxide poisoning, organophosphate poisoning, sulfur mustard poisoning, cardiac glycoside intoxication, monochloroacetic acid poisoning, chemotherapy-induced toxicity

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 4.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	2
PHASE3	1
PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT04877067	PHASE3	COMPLETED	Therapy of Toxic Optic Neuropathy Via Combination of Stem Cells With Electromagnetic Stimulation
NCT06173817	PHASE1	WITHDRAWN	The Use of Isocapnic Hyperventilation (iHV) for Treatment of Methanol Poisoned Patients
NCT04064801	Not specified	COMPLETED	Red Cell Distribution Width as a Predictor of Mortality in Acute Methanol Poisoning
NCT06931587	Not specified	COMPLETED	Methanol Poisoning