Microinvasive gastric cancer
diseaseOn this page
Also known as early gastric cancerEGCsuperficial gastric cancersuperficial spreading gastric cancersurface gastric cancer
Summary
Microinvasive gastric cancer (MONDO:0001060) is a cancer and 74 clinical trials. Top therapeutic interventions include methylene blue cation, indocyanine green acid form, and amoxicillin. A subtype of gastric adenocarcinoma — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Classification: Cancer
- Clinical trials: 74
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | microinvasive gastric cancer |
| Mondo ID | MONDO:0001060 |
| DOID | DOID:10541 |
| NCIT | C27131 |
| SNOMED CT | 276809004 |
| UMLS | C0349530 |
| MedGen | 138098 |
| GARD | 0027565 |
| Is cancer (heuristic) | yes |
Also known as: early gastric cancer · EGC · superficial gastric cancer · superficial spreading gastric cancer · surface gastric cancer
Disease family
This is a subtype of gastric adenocarcinoma. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › digestive system disorder › digestive system cancer › gastric cancer › gastric carcinoma › gastric adenocarcinoma › microinvasive gastric cancer
Related subtypes (8): gastric cardia adenocarcinoma, diffuse gastric adenocarcinoma, gastric intestinal type adenocarcinoma, gastric tubular adenocarcinoma, gastric papillary adenocarcinoma, mucinous gastric adenocarcinoma, signet ring cell gastric adenocarcinoma, CTNNA1-related diffuse gastric and lobular breast cancer syndrome
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 74.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 66 |
| PHASE2 | 3 |
| PHASE4 | 2 |
| PHASE3 | 2 |
| EARLY_PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT07312370 | PHASE4 | NOT_YET_RECRUITING | Esomeprazole Plus Sucralfate for Post-ESD Ulcer Healing |
| NCT01621451 | PHASE4 | UNKNOWN | Does Early Re-administration of Aspirin/Clopidogrel Increase the Risk of Bleeding From Artificial Ulcer After EMR or ESD? |
| NCT02407119 | PHASE3 | ACTIVE_NOT_RECRUITING | Effects of H. Pylori Eradication on the Gastric Preneoplastic Lesion and Neoplasm After ESD |
| NCT04032119 | PHASE3 | COMPLETED | RCT of Gastric ESD With or Without Epineprhine Added Solution |
| NCT04973475 | PHASE2 | NOT_YET_RECRUITING | Indocyanine Green Tracer Using in Laparoscopic Distal Gastrectomy for Early Gastric Cancer |
| NCT01504997 | PHASE2 | UNKNOWN | Phase II Study for Robot Assisted Distal Gastrectomy |
| NCT03837301 | PHASE2 | UNKNOWN | Non-exposure Simple Suturing EFTR (NESS-EFTR) With Laparoscopic Sentinel Lymph Node Navigation for EGC (Senorita3-phase 2) |
| NCT02325999 | EARLY_PHASE1 | UNKNOWN | Endoscopic Submucosal Dissection Combine With Laparoscopic Regional Lymph Node Dissection for Early Gastric Cancer |
| NCT02968069 | Not specified | NOT_YET_RECRUITING | A Predictive Model Based on Narrow Band Imaging for Early Gastric Cancerous Lesions |
| NCT03857737 | Not specified | NOT_YET_RECRUITING | Endoscopic Submucosal Dissection Versus Surgery in the Treatment of Early Gastric Cancer |
| NCT04665687 | Not specified | RECRUITING | Clinical Application of Genetic Sequencing of Early Gastric Cancer and Gastric Adenoma Patients |
| NCT05291728 | Not specified | RECRUITING | Screening for Early Gastric Cancer in Shaanxi Province |
| NCT05323929 | Not specified | RECRUITING | The Relationship Between Scar Formation and ESD Depth in Therapy for Gastric Carcinoma |
| NCT05978882 | Not specified | NOT_YET_RECRUITING | Feasibility Study of Sentinel Navigation Surgery in Early Gastric Cancer Using Fluorescence (SENORITA4) |
| NCT06389448 | Not specified | RECRUITING | Comparison of pCLE and EB in Gastric Lesion Diagnosis |
| NCT06748352 | Not specified | RECRUITING | Safety and Efficacy of Traction Robot-assisted Endoscopic Submucosal Dissection for Early Gastric Cancer |
| NCT06788548 | Not specified | RECRUITING | Fluorescence Guided Laparoscopic-Endoscopic Cooperative Sentinel Lymph Node Navigation Surgery Strategy for Early Gastric Cancer（IDEAL Stage 2b） |
| NCT06962293 | Not specified | RECRUITING | Magnetic Guided Counetrtraction During Endoscopic Submucosal Dissection |
| NCT07047937 | Not specified | ENROLLING_BY_INVITATION | Explainable Machine Learning for Predicting Early Gastric Cancer |
| NCT07253948 | Not specified | RECRUITING | Distribution Characteristics of Helicobacter Pylori |
| NCT07295002 | Not specified | NOT_YET_RECRUITING | Sentinel Node Resection With or Without LECS After Noncurative ESD for EGC |
| NCT07401303 | Not specified | NOT_YET_RECRUITING | Full-time RDI for ESD: Impact on Major Adverse Events and Procedure Time |
| NCT07405931 | Not specified | RECRUITING | Evaluation of the Effectiveness of Managing Chemotherapy Side Effects Using ePRO and a Standardized Telenursing Program for Cancer Patients |
| NCT07486518 | Not specified | NOT_YET_RECRUITING | A Multicentre Prospective Cohort Study of The Gastric Precancerous Epithelial Pathway Using High-Definition Endoscopy And Histopathology In India |
| NCT07507071 | Not specified | NOT_YET_RECRUITING | Comparison of the Sensitivity of pCLE and Pathological Biopsy for Gastric Mucosal Lesions |
| NCT07551466 | Not specified | RECRUITING | AI Model for Early Gastric Cancer Diagnosis Using Endoscopic Imaging |
| NCT07615374 | Not specified | ACTIVE_NOT_RECRUITING | Laparoscopic-endoscopic Surgery Assisted Sentinel Lymph Node Navigation Surgery for Early Gastric Cancer |
| NCT01132469 | Not specified | UNKNOWN | Efficacy and Safety Study of Endoscopic Submucosal Dissection for Early Gastric Cancer |
| NCT01364324 | Not specified | COMPLETED | Pharmacokinetics of Anti-tuberculosis Drugs in Gastrectomized Patients |
| NCT01435525 | Not specified | COMPLETED | Nexium Capsules Helicobacter Pylori Specific Clinical Experience Investigation |
| NCT01544413 | Not specified | COMPLETED | Quality Control Study of Laparoscopic Sentinel Node Biopsy in Early Gastric Cancer |
| NCT01643811 | Not specified | COMPLETED | Effect of Gastrectomy and Anastomosis on Diabetes and Hypertension in Early Gastric Cancer Patients |
| NCT01659632 | Not specified | UNKNOWN | Gastric Cancer Screening and Alarm Symptoms in Early Gastric Cancer |
| NCT01688687 | Not specified | COMPLETED | Conventional Biopsies vs pCLE for Diagnosis of Superficial Gastric Neoplasia |
| NCT01774266 | Not specified | UNKNOWN | Detection of Methylated Reprimo in Plasma for Asymptomatic Gastric Cancer |
| NCT01804998 | Not specified | COMPLETED | Multicenter Phase III Trial of Laparoscopic Sentinel Node Biopsy |
| NCT01806753 | Not specified | COMPLETED | Performance of Endoscopic Submucosal Dissection According to the Sedation Method |
| NCT01813994 | Not specified | COMPLETED | Role of Statin on the Gastric Inflammation in Patients at High Risk of Gastric Cancer |
| NCT01832246 | Not specified | UNKNOWN | Endoscopic Ultrasonographic Staging and Conventional Endoscopic Staging for Depth of Invasion for Early Gastric Cancer |
| NCT01921283 | Not specified | COMPLETED | Monitored Anesthesia Care With Propofol Plus Remifentanil During Endoscopic Submucosal Dissection: Evaluation of Bispectral Index Monitoring |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| METHYLENE BLUE CATION | 4 | 3 |
| INDOCYANINE GREEN ACID FORM | 4 | 2 |
| AMOXICILLIN | 4 | 1 |
| SUCRALFATE | 4 | 1 |
| CARNOSINE | 3 | 2 |
| REBAMIPIDE | 3 | 1 |
| RACEPINEPHRINE | 2 | 1 |
| CHEMBL2367706 | 0 | 1 |
| CHEMBL1703336 | 0 | 1 |