Mixed germ cell tumor

Summary

Mixed germ cell tumor (MONDO:0015864) is a cancer (an umbrella term covering 6 Mondo subtypes) and 3 clinical trials. Top therapeutic interventions include ifosfamide and etoposide phosphate. A subtype of malignant germ cell tumor — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer
• Prevalence: <1 / 1 000 000 (Europe) [Orphanet-validated]
• Umbrella term: 6 Mondo subtypes
• Clinical trials: 3

Clinical features

Epidemiology

Prevalence records

1 prevalence record(s), Orphanet:

Type	Class	Value	Geography	Validation
Annual incidence	<1 / 1 000 000	0.01	Europe	Validated

Identifiers

Disease identifiers

Field	Value
Canonical name	mixed germ cell tumor
Mondo ID	MONDO:0015864
Orphanet	180234
DOID	DOID:3306
NCIT	C4290
UMLS	C0334524
MedGen	87257
GARD	0020202
Is cancer (heuristic)	yes

Also known as: combined germ cell neoplasm · combined germ cell tumor · combined germ cell tumour · mixed germ cell cancer · mixed germ cell neoplasm · mixed germ cell tumor

Data availability: 8 cell lines · 10 intOGen driver records.

Disease family

This is a subtype of malignant germ cell tumor. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › cancer › malignant germ cell tumor › mixed germ cell tumor

Related subtypes (12): germinoma, seminoma, dysgerminoma, extragonadal germ cell cancer, pulmonary artery choriocarcinoma, malignant testicular germ cell tumor, malignant teratoma, malignant childhood germ cell neoplasm, vaginal germ cell malignant tumor, malignant germ cell tumor of corpus uteri, malignant germ cell tumor of cervix uteri, malignant germ cell tumor of ovary

Subtypes (6): mixed extragonadal germ cell cancer, teratocarcinoma, mixed testicular germ cell cancer, ovarian mixed germ cell neoplasm, mixed germ cell tumor of vulva, mixed teratoma and seminoma

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 3.

Phase distribution (across all retrieved trials)

Phase	Trials
PHASE3	1
PHASE2	1
Not specified	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT02375204	PHASE3	ACTIVE_NOT_RECRUITING	Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients with Relapsed or Refractory Germ Cell Tumors
NCT04684368	PHASE2	RECRUITING	A Study of a New Way to Treat Children and Young Adults With a Brain Tumor Called NGGCT
NCT05564026	Not specified	RECRUITING	Molecular Epidemiology of Pediatric Germ Cell Tumors

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
IFOSFAMIDE	4	2
ETOPOSIDE PHOSPHATE	4	1