Mixed glioma
diseaseOn this page
Also known as glioma, mixedglioma, mixed, malignantmixed glial neoplasmmixed glial tumormixed glial tumourmixed glioma (morphologic abnormality)mixed gliomasmixed neuroglial neoplasmmixed neuroglial tumormixed neuroglial tumour
Summary
Mixed glioma (MONDO:0003268) is a cancer and 17 clinical trials. Top therapeutic interventions include mercaptopurine anhydrous, carmustine, and etoposide phosphate. A subtype of glioma — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Classification: Cancer
- Clinical trials: 17
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | mixed glioma |
| Mondo ID | MONDO:0003268 |
| DOID | DOID:5076 |
| NCIT | C3903 |
| SNOMED CT | 443937008 |
| UMLS | C0259783 |
| MedGen | 75477 |
| GARD | 0023431 |
| Is cancer (heuristic) | yes |
Also known as: glioma, mixed · glioma, mixed, malignant · mixed glial neoplasm · mixed glial tumor · mixed glial tumour · mixed glioma · mixed glioma (morphologic abnormality) · mixed gliomas · mixed neuroglial neoplasm · mixed neuroglial tumor · mixed neuroglial tumour
Disease family
This is a subtype of glioma. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › nervous system neoplasm › neuroepithelial neoplasm › glioma › mixed glioma
Related subtypes (8): nerve sheath neoplasm, ependymal tumor, optic pathway glioma, astroblastoma, astrocytic tumor, low grade glioma, malignant glioma, diffuse glioma, H3 G34 mutant
Subtypes (3): mixed astrocytoma-ependymoma-oligodendroglioma, mixed astrocytoma-ependymoma, oligoastrocytoma
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 17.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| PHASE1 | 8 |
| PHASE2 | 4 |
| Not specified | 3 |
| PHASE1/PHASE2 | 1 |
| EARLY_PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT00003473 | PHASE2 | COMPLETED | Antineoplaston Therapy in Treating Patients With Recurrent or Refractory Mixed Gliomas |
| NCT00004688 | PHASE2 | COMPLETED | Phase II Study of Carmustine, Streptozocin, and Mercaptopurine for Refractory or Recurrent Brain Neoplasms |
| NCT00303849 | PHASE1/PHASE2 | COMPLETED | Carboplatin, Melphalan, Etoposide Phosphate, Mannitol, and Sodium Thiosulfate in Treating Patients With Previously Treated Brain Tumors |
| NCT01095094 | PHASE2 | TERMINATED | Ritonavir and Lopinavir in Treating Patients With Progressive or Recurrent High-Grade Glioma |
| NCT02372409 | PHASE2 | TERMINATED | Using MRI-Guided Laser Heat Ablation to Induce Disruption of the Peritumoral Blood Brain Barrier to Enhance Delivery and Efficacy of Treatment of Pediatric Brain Tumors |
| NCT00019578 | PHASE1 | COMPLETED | Stereotactic Radiosurgery in Treating Patients With Brain Tumors |
| NCT00390299 | PHASE1 | COMPLETED | Viral Therapy in Treating Patients With Recurrent Glioblastoma Multiforme |
| NCT00704080 | PHASE1 | COMPLETED | A Study of XL765 (SAR245409) in Combination With Temozolomide With and Without Radiation in Adults With Malignant Gliomas |
| NCT01082926 | PHASE1 | COMPLETED | Phase I Study of Cellular Immunotherapy for Recurrent/Refractory Malignant Glioma Using Intratumoral Infusions of GRm13Z40-2, An Allogeneic CD8+ Cytolitic T-Cell Line Genetically Modified to Express the IL 13-Zetakine and HyTK and to be Resistant to Glucocorticoids, in Combination With Interleukin-2 |
| NCT01250470 | PHASE1 | COMPLETED | Vaccine Therapy and Sargramostim in Treating Patients With Malignant Glioma |
| NCT02101905 | PHASE1 | COMPLETED | Lapatinib Ditosylate Before Surgery in Treating Patients With Recurrent High-Grade Glioma |
| NCT02238496 | PHASE1 | COMPLETED | Perifosine and Torisel (Temsirolimus) for Recurrent/Progressive Malignant Gliomas |
| NCT04541225 | PHASE1 | TERMINATED | Study of NUV-422 in Adults With Recurrent or Refractory High-grade Gliomas and Solid Tumors |
| NCT02976441 | EARLY_PHASE1 | WITHDRAWN | Autologous Stem Cell Collection and Reinfusion in Newly Diagnosed High Grade Gliomas |
| NCT04461938 | Not specified | ACTIVE_NOT_RECRUITING | Characterization of Metabolic Changes in the Glioma Tumor Tissue Induced by Transient Fasting (ERGO3) |
| NCT05100173 | Not specified | COMPLETED | Clinical Evaluation of Genetron IDH1 PCR Kit in Glioma Patients |
| NCT05984667 | Not specified | COMPLETED | C-SMART: Cognitive Strategies, Mindfulness, and Rehabilitation Therapy for Patients With Primary Brain Tumors |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| MERCAPTOPURINE ANHYDROUS | 4 | 3 |
| CARMUSTINE | 4 | 1 |
| ETOPOSIDE PHOSPHATE | 4 | 1 |
| MANNITOL | 4 | 1 |
| SODIUM THIOSULFATE | 4 | 1 |
| SORBITOL | 4 | 1 |
| STREPTOZOCIN | 4 | 1 |
| ANTINEOPLASTON A10 | 3 | 1 |
| PERIFOSINE | 3 | 1 |
| VOXTALISIB | 2 | 1 |
| CHEMBL4783128 | 0 | 1 |
| CHEMBL3753202 | 0 | 1 |
| CHEMBL3349370 | 0 | 1 |