Monkeypox

Summary

Monkeypox (MONDO:0002594) is a disease and 40 clinical trials. Top therapeutic interventions include tecovirimat. A subtype of primary viral infectious disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 40

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	monkeypox
Mondo ID	MONDO:0002594
MeSH	D045908
DOID	DOID:3292
ICD-10-CM	B04
NCIT	C128421
SNOMED CT	359814004
UMLS	C0276180
MedGen	124442
Is cancer (heuristic)	no

Also known as: infections, Monkeypox virus · Monkeypox virus infection

Disease family

Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › infectious disease › viral infectious disease › primary viral infectious disease › monkeypox

Related subtypes (31): plantar wart, smallpox, rubella, human papilloma virus infection, Rotavirus infection, Arenaviridae infectious disease, Astroviridae infectious disease, Caliciviridae infectious disease, cowpox, Flaviviridae infectious disease, Hepadnaviridae infectious disease, Herpesviridae infectious disease, influenza, Mononegavirales infectious disease, Nidovirales infectious disease, phlebotomus fever, Picornaviridae infectious disease, polyomavirus infectious disease, Togaviridae infectious disease, viral encephalitis, viral hepatitis, viral pneumonia, viral exanthem, deltaretrovirus infections, Bunyaviridae infectious disease, viral sexually transmitted disease, lentivirus infection, viral myocarditis, viral pericarditis, adenoviridae infectious disease, aleutian mink disease, human

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

1 approved. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.

Drug	Development status
Vaccinia Virus, Live Modified	Approved (phase 4)

Clinical trials & evidence

Clinical trials

Clinical trials: 40.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	21
PHASE2	6
PHASE3	4
PHASE1	4
PHASE4	3
PHASE2/PHASE3	1
PHASE1/PHASE2	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT05745987	PHASE4	RECRUITING	Smallpox Vaccine for Mpox Post-Exposure Prophylaxis: A Cluster RCT
NCT06156566	PHASE4	RECRUITING	European Trial Into Mpox Infection
NCT05734508	PHASE4	COMPLETED	Assessment of Safety Profile of MVA-BN Vaccine in the PALM-007 Study in DRC
NCT05597735	PHASE3	ACTIVE_NOT_RECRUITING	Assessment of the Efficacy and Safety of Tecovirimat in Patients With Monkeypox Virus Disease
NCT06223919	PHASE3	ACTIVE_NOT_RECRUITING	Efficacy/Effectiveness, Safety, and Immunogenicity of LC16m8 Mpox Vaccine in Colombia
NCT02977715	PHASE3	COMPLETED	JYNNEOS Smallpox Vaccine in Adult Healthcare Personnel at Risk for Mpox in the Democratic Republic of the Congo
NCT05534165	PHASE3	SUSPENDED	Tecovirimat in Non-hospitalized Patients With Monkeypox
NCT05846243	PHASE2/PHASE3	COMPLETED	Study on Immunogenicity, Reactogenicity and Safety of the VACΔ6 Vaccine in Volunteers Aged 18-60 Years
NCT06549530	PHASE2	ACTIVE_NOT_RECRUITING	Open-label, Multicenter Immunogenicity and Safety Study of MVA-BN Vaccine in Children From 2 Years to Less Than 12 Years of Age Compared to Adults for the Prevention of Smallpox, Mpox, and Related Orthopoxvirus Infections
NCT07199569	PHASE2	ACTIVE_NOT_RECRUITING	Comparability Trial of the MVA-BN Vaccine Manufactured in Different Production Cells
NCT07253675	PHASE2	NOT_YET_RECRUITING	Evaluate the Safety and Immunogenicity of the MVA-SIBP Vaccine in the Democratic Republic of the Congo
NCT05512949	PHASE2	COMPLETED	Trial to Evaluate the Immunogenicity of Dose Reduction Strategies of the MVA-BN Monkeypox Vaccine
NCT05559099	PHASE2	COMPLETED	Tecovirimat for Treatment of Monkeypox Virus
NCT05740982	PHASE2	COMPLETED	A Phase 2 Randomized Multisite Trial to Inform Public Health Strategies Involving the Use of MVA-BN Vaccine for Mpox
NCT05988203	PHASE1/PHASE2	COMPLETED	A Clinical Study Investigating the Safety and Immune Responses After Immunization With Investigational Monkeypox Vaccines
NCT06771479	PHASE1	RECRUITING	A Study Evaluating the Safety and Immunogenicity of MVA Strain Monkeypox Attenuated Live Vaccine
NCT07377175	PHASE1	RECRUITING	Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of BSY001 After Single/Multiple Doses.
NCT05762523	PHASE1	COMPLETED	Safety and Tolerability Study of the VAC∆6 Vaccine in Volunteers Aged 18-40 Years
NCT05976100	PHASE1	COMPLETED	Study of the Safety, Tolerability, Pharmacokinetics of NIOCH-14 in Volunteers Aged 18-50 Years
NCT02080767	Not specified	AVAILABLE	Tecovirimat (ST-246) Treatment for Orthopox Virus Exposure
NCT05562323	Not specified	RECRUITING	Characterization of Vaccine-induced Responses Against Monkeypox (MoVIHvax) An Observational Prospective Cohort Study
NCT05654883	Not specified	ENROLLING_BY_INVITATION	New York City Observational Study of Mpox Immunity
NCT05784038	Not specified	RECRUITING	Observational, Prospective, Cohort Study of Mpox Infection in Brazil (NETPOX)
NCT05879965	Not specified	RECRUITING	Prospective Study for the FOLLOW-UP of Human Monkeypox Cases and Smallpox Vaccinees at Risk
NCT06840197	Not specified	NOT_YET_RECRUITING	DiagRaMIE Mpox Virus-RDC for the Diagnostic of Monkeypox
NCT06840860	Not specified	RECRUITING	Epidemiological and Pathophysiological Insights Through a Cross-sectional Survey (EPIC)
NCT06885853	Not specified	RECRUITING	Evaluation of Long-term Immunogenicity of a Boost Dose of MVA-BN Vaccine
NCT07067723	Not specified	ENROLLING_BY_INVITATION	Epidemiological and Clinical Characteristics of Human Mpox Outbreak in Equateur Province in the Democratic Republic of Congo (Part2)
NCT07342829	Not specified	NOT_YET_RECRUITING	Prospective Follow-up After MVA-BN Booster Vaccination
NCT07534267	Not specified	NOT_YET_RECRUITING	Understanding MPXV Viral Clearance, Transmission Dynamics, and Mpox Vaccine Effectiveness in West Africa : Guinea
NCT03745131	Not specified	COMPLETED	Cohort Study of Healthcare Workers Receiving Imvanex®
NCT05058898	Not specified	UNKNOWN	A One Health Study of Monkeypox Human Infection
NCT05476744	Not specified	COMPLETED	Viral Clearance and Epidemiological Characteristics in Patients With Monkeypox
NCT05567939	Not specified	TERMINATED	Clinical, Virological, Immunological, Psychosocial and Epidemiological Consequences of Human Monkeypox Virus (ProMPX)
NCT05629299	Not specified	UNKNOWN	Pilot Study to Detect Monkey Pox Virus in Sperm: POXSPERM
NCT05947786	Not specified	UNKNOWN	Mpox Paediatric and Adolescent Clinical Study
NCT05965427	Not specified	COMPLETED	Morbidity, Mortality And Risk Factors of Mpox in HIV Negative High Risk Sexual Health Clinic Attenders and People Living With HIV
NCT06045923	Not specified	TERMINATED	Virologic and Immunologic Characteristics of Severe Mpox in Persons With Advanced HIV
NCT06291259	Not specified	UNKNOWN	Mpox Prospective Observational Cohort Study
NCT06579885	Not specified	COMPLETED	Ocular Complications of Mpox in the Democratic Republic Congo

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
TECOVIRIMAT	4	5
CHEMBL485653	0	5