Morton neuroma

Summary

Morton neuroma (MONDO:0700058) is a disease and 13 clinical trials. Top therapeutic interventions include sodium chloride. A subtype of neuroma — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 13

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	Morton neuroma
Mondo ID	MONDO:0700058
NCIT	C4075
SNOMED CT	30085007
UMLS	C0311337
MedGen	90231
Is cancer (heuristic)	no

Also known as: interdigital nerve compression syndrome · interdigital neuralgia · interdigital neuritis · interdigital neuroma · intermetatarsal neuroma · Morton entrapment · Morton metatarsalgia

Disease family

This is a subtype of neuroma. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › nervous system disorder › peripheral nervous system disorder › neuroma › Morton neuroma

Related subtypes (1): multiple mucosal neuroma

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 13.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	10
PHASE4	1
PHASE2	1
PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT03046108	PHASE4	UNKNOWN	Blind and Ultrasound Guided Injection in Morton Neuroma
NCT07227649	PHASE2	NOT_YET_RECRUITING	NAC-REPAIR for Post-surgical Pain
NCT02838758	PHASE1	COMPLETED	Compare Ultrasound Assisted Cold Therapy and Lidocaine Injection to Treat Morton’s Neuroma
NCT05501262	Not specified	RECRUITING	Comparative Effectiveness of Cryoablation Versus Steroid and Lidocaine Alone for Treatment of Morton’s Neuroma
NCT05685160	Not specified	ENROLLING_BY_INVITATION	US and MRI of the Forefoot: Intermetatarsal Bursitis or Morton’s Neuroma
NCT00284414	Not specified	WITHDRAWN	Is Ultrasonography Comparable to MRI for the Detection of Morton Neuroma of the Foot?
NCT03504462	Not specified	COMPLETED	Feasibility of Specific Anesthesia of the Forefoot Preserving the Sensitivity of the Heel for Foot Surgery
NCT03511677	Not specified	COMPLETED	Insole on Morton’s Neuroma
NCT05012488	Not specified	COMPLETED	Comparison of the Effects of Morton’s Neuroma on Foot Pressure Distribution and Gait Parameters in Pes Planus and Pes Cavus Patients
NCT05411224	Not specified	UNKNOWN	Investigation of the Effect of Custom Made Insoles on Foot Pressure Distribution and Gait Parameters in Patients With Morton’s Neuroma
NCT05550831	Not specified	UNKNOWN	Radiofrequency Before to Surgical Removal of a Recalcitrant Morton´s Neuroma
NCT05707572	Not specified	COMPLETED	Morton’s Neuroma: Manipulation Versus Steroid Injection
NCT07103070	Not specified	COMPLETED	A Test of Efficacy and Foot Position Alteration in Patients Wearing Good Feet Arch Supports for the Treatment of Pain

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
SODIUM CHLORIDE	4	1