Mueller-weiss syndrome
diseaseOn this page
Also known as Brailsford diseaseMueller-Weiss osteonecrosis of the tarsal bone
Summary
Mueller-weiss syndrome (MONDO:0035452) is a disease. A subtype of bone disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Prevalence: <1 / 1 000 000 (Worldwide) [Orphanet-validated]
- Phenotypes (HPO): 21
Clinical features
Epidemiology
Prevalence records
2 prevalence record(s), Orphanet:
| Type | Class | Value | Geography | Validation |
|---|---|---|---|---|
| Cases/families | 277 | Worldwide | Validated | |
| Point prevalence | <1 / 1 000 000 | Worldwide | Validated |
Signs & symptoms
Clinical features (HPO)
21 HPO clinical features (Orphanet curated; top 21 by frequency):
| HPO ID | Term | Frequency |
|---|---|---|
| HP:0025238 | Foot pain | Very frequent (80-99%) |
| HP:0001288 | Gait disturbance | Frequent (30-79%) |
| HP:0001387 | Joint stiffness | Frequent (30-79%) |
| HP:0005656 | Positional foot deformity | Frequent (30-79%) |
| HP:0010505 | Limitation of movement at ankles | Frequent (30-79%) |
| HP:0010741 | Pedal edema | Frequent (30-79%) |
| HP:0010885 | Avascular necrosis | Frequent (30-79%) |
| HP:0012098 | Edema of the dorsum of feet | Frequent (30-79%) |
| HP:0030871 | Facet joint arthrosis | Frequent (30-79%) |
| HP:0100339 | Abnormality of the os naviculare pedis | Frequent (30-79%) |
| HP:0100662 | Chondritis | Frequent (30-79%) |
| HP:0100925 | Sclerosis of foot bone | Frequent (30-79%) |
| HP:0001369 | Arthritis | Occasional (5-29%) |
| HP:0001763 | Pes planus | Occasional (5-29%) |
| HP:0005063 | Fragmented, irregular epiphyses | Occasional (5-29%) |
| HP:0005086 | Knee osteoarthritis | Occasional (5-29%) |
| HP:0008110 | Equinovarus deformity | Occasional (5-29%) |
| HP:0008124 | Talipes calcaneovarus | Occasional (5-29%) |
| HP:0032153 | Joint subluxation | Occasional (5-29%) |
| HP:0100535 | Tibiofibular diastasis | Occasional (5-29%) |
| HP:0100694 | Tibial torsion | Occasional (5-29%) |
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | mueller-weiss syndrome |
| Mondo ID | MONDO:0035452 |
| Orphanet | 566943 |
| UMLS | C4761149 |
| MedGen | 1708314 |
| GARD | 0022283 |
| Is cancer (heuristic) | no |
Also known as: Brailsford disease · Mueller-Weiss osteonecrosis of the tarsal bone
Disease family
This is a subtype of bone disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › skeletal system disorder › bone disorder › mueller-weiss syndrome
Related subtypes (26): bone remodeling disease, disease of bone structure, mucopolysaccharidosis type 1, bone inflammation disease, Baastrup syndrome, periostitis, osteonecrosis, bone development disease, ainhum, cervical rib disease, coxoauricular syndrome, metachondromatosis, mucopolysaccharidosis type 9, Sagliker syndrome, mixed sclerosing bone dystrophy with extra-skeletal manifestations, GM1 gangliosidosis, skeletal dysplasia, autosomal dominant myopia-midfacial retrusion-sensorineural hearing loss-rhizomelic dysplasia syndrome, mucopolysaccharidosis type 3, bone neoplasm, skull disorder, Duane anomaly-myopathy-scoliosis syndrome, SLC10A7-congenital disorder of glycosylation, metabolic bone disorder, proteoglycan-related bone disorder, ACAN-related short stature spectrum
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 0.
Related Atlas pages
No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.