Multifocal atrial tachycardia

Summary

Multifocal atrial tachycardia (MONDO:0017988) is a disease. A subtype of cardiac rhythm disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: Unknown (Worldwide) [Orphanet-validated]
• Phenotypes (HPO): 25

Clinical features

Epidemiology

Prevalence records

1 prevalence record(s), Orphanet:

Type	Class	Value	Geography	Validation
Prevalence at birth	1-9 / 1 000 000	0.67	Worldwide	Validated

Signs & symptoms

Clinical features (HPO)

25 HPO clinical features (Orphanet curated; top 25 by frequency):

HPO ID	Term	Frequency
HP:0001649	Tachycardia	Obligate (100%)
HP:0031593	Abnormal PR interval	Obligate (100%)
HP:6001086	Irregular RR interval	Obligate (100%)
HP:6001087	Irregular P-P interval	Obligate (100%)
HP:0004749	Atrial flutter	Frequent (30-79%)
HP:0005110	Atrial fibrillation	Frequent (30-79%)
HP:0034376	Atrioventricular valve regurgitation	Frequent (30-79%)
HP:6000264	Fetal tachycardia	Frequent (30-79%)
HP:0001629	Ventricular septal defect	Occasional (5-29%)
HP:0001631	Atrial septal defect	Occasional (5-29%)
HP:0001639	Hypertrophic cardiomyopathy	Occasional (5-29%)
HP:0001642	Pulmonic stenosis	Occasional (5-29%)
HP:0002094	Dyspnea	Occasional (5-29%)
HP:0002615	Hypotension	Occasional (5-29%)
HP:0002789	Tachypnea	Occasional (5-29%)
HP:0004758	Effort-induced polymorphic ventricular tachycardia	Occasional (5-29%)
HP:0005162	Abnormal left ventricular function	Occasional (5-29%)
HP:0008872	Feeding difficulties in infancy	Occasional (5-29%)
HP:0011717	Atrioventricular reentrant tachycardia	Occasional (5-29%)
HP:4000141	Left ventricular dilatation	Occasional (5-29%)
HP:0000028	Cryptorchidism	Very rare (<1-4%)
HP:0000821	Hypothyroidism	Very rare (<1-4%)
HP:0001254	Lethargy	Very rare (<1-4%)
HP:0001279	Syncope	Very rare (<1-4%)
HP:0006671	Paroxysmal atrial tachycardia	Very rare (<1-4%)

Identifiers

Disease identifiers

Field	Value
Canonical name	multifocal atrial tachycardia
Mondo ID	MONDO:0017988
Orphanet	3282
ICD-11	262929566
SNOMED CT	49982000
UMLS	C0221158
MedGen	66362
GARD	0001235
Is cancer (heuristic)	no

Also known as: chaotic atrial tachycardia · MAT · multifocal atrial tachycardia · multifocal atrial tachycardia (disease)

Data availability: 1 HPO phenotype.

Disease family

This is a subtype of cardiac rhythm disease. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › cardiovascular disorder › heart disorder › cardiac rhythm disease › multifocal atrial tachycardia

Related subtypes (16): ventricular fibrillation, cardiac arrest, atrial fibrillation, ventricular tachycardia, atrial tachycardia, torsade-de-pointes syndrome with short coupling interval, sinoatrial node dysfunction and deafness, sino-auricular heart block, His bundle tachycardia, incessant infant ventricular tachycardia, ventricular arrhythmias due to cardiac ryanodine receptor calcium release deficiency syndrome, sudden arrhythmia death syndrome, cardiac conduction defect, sudden cardiac arrest, cardiac conduction disease with or without cardiomyoopathy, cardiogenetic rhythm disorder

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.