Mycetoma

Summary

Mycetoma (MONDO:0016823) is a disease and 5 clinical trials. Top therapeutic interventions include itraconazole, fosravuconazole, and hyoscyamine. A subtype of infectious disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: 1-9 / 100 000 (Sudan) [Orphanet-validated]
• Phenotypes (HPO): 29
• Clinical trials: 5

Clinical features

Epidemiology

Prevalence records

2 prevalence record(s), Orphanet:

Type	Class	Value	Geography	Validation
Point prevalence	1-9 / 100 000	0.09	Sudan	Validated
Point prevalence	1-9 / 100 000	0.2	Mauritania	Validated

Signs & symptoms

Clinical features (HPO)

29 HPO clinical features (Orphanet curated; top 29 by frequency):

HPO ID	Term	Frequency
HP:0001015	Prominent superficial veins	Frequent (30-79%)
HP:0001482	Subcutaneous nodule	Frequent (30-79%)
HP:0002841	Recurrent fungal infections	Frequent (30-79%)
HP:0003330	Abnormal bone structure	Frequent (30-79%)
HP:0005406	Recurrent bacterial skin infections	Frequent (30-79%)
HP:0010219	Structural foot deformity	Frequent (30-79%)
HP:0030053	Stiff skin	Frequent (30-79%)
HP:0031288	Cobblestone-like hyperkeratosis	Frequent (30-79%)
HP:0000939	Osteoporosis	Occasional (5-29%)
HP:0001155	Abnormality of the hand	Occasional (5-29%)
HP:0002754	Osteomyelitis	Occasional (5-29%)
HP:0002815	Abnormality of the knee	Occasional (5-29%)
HP:0011844	Abnormal appendicular skeleton morphology	Occasional (5-29%)
HP:0025245	Cutaneous cyst	Occasional (5-29%)
HP:0040072	Abnormal forearm bone morphology	Occasional (5-29%)
HP:0100763	Abnormality of the lymphatic system	Occasional (5-29%)
HP:0000152	Abnormality of head or neck	Very rare (<1-4%)
HP:0000707	Abnormality of the nervous system	Very rare (<1-4%)
HP:0000765	Abnormal thorax morphology	Very rare (<1-4%)
HP:0002661	Painless fractures due to injury	Very rare (<1-4%)
HP:0002756	Pathologic fracture	Very rare (<1-4%)
HP:0002953	Vertebral compression fracture	Very rare (<1-4%)
HP:0003312	Abnormal form of the vertebral bodies	Very rare (<1-4%)
HP:0003418	Back pain	Very rare (<1-4%)
HP:0010550	Paraplegia	Very rare (<1-4%)
HP:0012062	Bone cyst	Very rare (<1-4%)
HP:0031500	Abdominal mass	Very rare (<1-4%)
HP:0031501	Pelvic mass	Very rare (<1-4%)
HP:0100809	Scalp tenderness	Very rare (<1-4%)

Identifiers

Disease identifiers

Field	Value
Canonical name	mycetoma
Mondo ID	MONDO:0016823
MeSH	D008271
Orphanet	2583
ICD-10-CM	B47
NCIT	C85505
SNOMED CT	410039003
UMLS	C0024449
MedGen	44241
GARD	0003862
MedDRA	10028427
Anatomy (UBERON)	UBERON:0002072
Is cancer (heuristic)	no

Also known as: Madura foot

Disease family

This is a subtype of infectious disease. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › infectious disease › mycetoma

Related subtypes (34): infective endocarditis, hirudiniasis, fungal infectious disease, infectious peritonitis, epididymitis, viral infectious disease, bacterial infectious disease, parasitic infectious disease, abscess, Ciliophora infectious disease, hookworm infectious disease, infectious embryofetopathy, infectious disorder of the nervous system, ear infection, sexually transmitted disease, puerperal infection, Acanthamoeba infectious disease, infectious myositis, infective vaginitis, skin disorder caused by infection, respiratory tract infectious disorder, nail infection, infective arthritis, digestive system infectious disorder, nosocomial infection, eye infectious disorder, prosthesis-related infectious disease, vector-borne disease, coinfection, urinary tract infection, hemorrhagic fever, protothecosis, pythiosis, infectious disease with sepsis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 5.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	4
PHASE2	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT03086226	PHASE2	COMPLETED	Proof-of-Concept Superiority Trial of Fosravuconazole Versus Itraconazole for Eumycetoma in Sudan
NCT06512714	Not specified	RECRUITING	Mycetoma Retrospective Data Collection
NCT07506967	Not specified	NOT_YET_RECRUITING	Early Detection and AI-Based Management of Skin-Related Neglected Tropical Diseases in Sub-Saharan Africa by Frontline Health Workers
NCT04401969	Not specified	COMPLETED	Tissue Microenvironment Signatures of the Mycetoma Granuloma
NCT06523998	Not specified	COMPLETED	A Study on Rare Dermatological Infections Conducted at Three Major Reference Hospitals in Costa Rica.

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
ITRACONAZOLE	4	1
FOSRAVUCONAZOLE	2	1
HYOSCYAMINE	-1	1