Necrotizing fasciitis

Summary

Necrotizing fasciitis (MONDO:0004835) is a disease and 13 clinical trials. Top therapeutic interventions include sodium chloride and reltecimod. A subtype of fasciitis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 13

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	necrotizing fasciitis
Mondo ID	MONDO:0004835
MeSH	D019115
Orphanet	699697
DOID	DOID:9602
ICD-10-CM	M72.6
NCIT	C84916
SNOMED CT	52486002
UMLS	C0238124
MedGen	66763
Is cancer (heuristic)	no

Disease family

This is a subtype of fasciitis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › fasciitis › necrotizing fasciitis

Related subtypes (5): nodular fasciitis, proliferative fasciitis, plantar fasciitis, ischemic fasciitis, eosinophilic fasciitis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 13.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	10
PHASE4	1
PHASE3	1
PHASE2	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT06073301	PHASE4	ACTIVE_NOT_RECRUITING	AFS Compared to AHC in Treatment of Necrotizing Fasciitis NF
NCT02469857	PHASE3	COMPLETED	Phase III Efficacy and Safety Study of AB103 in the Treatment of Patients With Necrotizing Soft Tissue Infections
NCT02111161	PHASE2	COMPLETED	Immunoglobulin for Necrotizing Soft Tissue Infections: a Randomised Controlled Trial
NCT00353275	Not specified	TERMINATED	Hyperglycemia in Surgical Infections
NCT00538577	Not specified	COMPLETED	Outcome and Related Factors of Necrotizing Fasciitis of the Limb
NCT01139112	Not specified	COMPLETED	Klebsiella Pneumoniae Necrotizing Fasciitis: Clinical and Microbiological Features
NCT01731483	Not specified	COMPLETED	Coagulation and Fibrinolysis as Virulence Factors for Invasive Staphylococcus Aureus and Streptococcus Infections
NCT01790698	Not specified	COMPLETED	Systems Medicine to Study Necrotizing Soft Tissue Infections (NSTIs).
NCT02169128	Not specified	UNKNOWN	Severe Soft Tissue Infections: Perspectives of Patients and Significant Others
NCT02180906	Not specified	COMPLETED	Biomarkers in Patients With Flesh-eating Bacterial Infections
NCT02501382	Not specified	COMPLETED	Modulation of Biomarkers in Patients With Flesh-eating Bacterial Infections After With Hyperbaric Oxygen Treatment
NCT04091672	Not specified	COMPLETED	RECELL® System Combined With Meshed Autograft for Reduction of Donor Skin Harvesting in Soft Tissue Reconstruction
NCT05116956	Not specified	UNKNOWN	SKin and Soft Tissue Necrotizing INfections in the Intensive Care Unit: a Prospective Multi-national Cohort Study

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
SODIUM CHLORIDE	4	2
RELTECIMOD	3	1