Neonatal alloimmune neutropenia
diseaseOn this page
Summary
Neonatal alloimmune neutropenia (MONDO:0018739) is a disease. A subtype of neutropenia — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Prevalence: Unknown (Europe) [Orphanet-validated]
- Phenotypes (HPO): 12
Clinical features
Epidemiology
Prevalence records
1 prevalence record(s), Orphanet:
| Type | Class | Value | Geography | Validation |
|---|---|---|---|---|
| Prevalence at birth | 1-5 / 10 000 | 16.6 | Poland | Validated |
Signs & symptoms
Clinical features (HPO)
12 HPO clinical features (Orphanet curated; top 12 by frequency):
| HPO ID | Term | Frequency |
|---|---|---|
| HP:0001904 | Neutropenia in presence of anti-neutropil antibodies | Very frequent (80-99%) |
| HP:0003453 | Antineutrophil antibody positivity | Very frequent (80-99%) |
| HP:0002090 | Pneumonia | Frequent (30-79%) |
| HP:0032169 | Severe infection | Frequent (30-79%) |
| HP:0000952 | Jaundice | Occasional (5-29%) |
| HP:0001287 | Meningitis | Occasional (5-29%) |
| HP:0001945 | Fever | Occasional (5-29%) |
| HP:0005268 | Spontaneous abortion | Occasional (5-29%) |
| HP:0005968 | Temperature instability | Occasional (5-29%) |
| HP:0009800 | Maternal diabetes | Occasional (5-29%) |
| HP:0032435 | Neonatal omphalitis | Occasional (5-29%) |
| HP:0100806 | Sepsis | Occasional (5-29%) |
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | neonatal alloimmune neutropenia |
| Mondo ID | MONDO:0018739 |
| Orphanet | 464370 |
| SNOMED CT | 14333004 |
| UMLS | C0272176 |
| MedGen | 543869 |
| GARD | 0021929 |
| Is cancer (heuristic) | no |
Disease family
This is a subtype of neutropenia. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › immune system disorder › leukocyte disorder › leukopenia › agranulocytosis › neutropenia › neonatal alloimmune neutropenia
Related subtypes (3): transient neonatal neutropenia, constitutional neutropenia, ELANE-related neutropenia
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 0.
Related Atlas pages
No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.