Neonatal respiratory failure
diseaseOn this page
Also known as respiratory failure of newborn
Summary
Neonatal respiratory failure (MONDO:0001207) is a disease and 19 clinical trials. Top therapeutic interventions include dextrose. A subtype of acute respiratory failure — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 19
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | neonatal respiratory failure |
| Mondo ID | MONDO:0001207 |
| DOID | DOID:11161 |
| ICD-10-CM | P28.5 |
| SNOMED CT | 95619009 |
| UMLS | C0521648 |
| MedGen | 105483 |
| Is cancer (heuristic) | no |
Also known as: respiratory failure of newborn
Disease family
This is a subtype of acute respiratory failure. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › acute disease › acute respiratory failure › neonatal respiratory failure
Related subtypes (2): acute respiratory distress syndrome, pulmonary edema
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 19.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 15 |
| PHASE3 | 2 |
| PHASE2/PHASE3 | 2 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT07493785 | PHASE2/PHASE3 | NOT_YET_RECRUITING | Dexmedetomidine for Invasive Ventilation In the NEOnate |
| NCT01318824 | PHASE3 | UNKNOWN | A Study of Bi-Level Positive Airway Pressure (BIPAP) Versus Non Invasive Positive Pressure Ventilation (NIPPV) for Neonatal Respiratory Failure |
| NCT01379820 | PHASE2/PHASE3 | UNKNOWN | Use of Orotracheal Continuous Positive Airway Pressure (CPAP) in Newborns With Respiratory Failure |
| NCT01778829 | PHASE3 | UNKNOWN | Non Invasive Ventilation Versus Continuous Positive Airway Pressure After Extubation of Very Low Birth Weight Infants. |
| NCT05451953 | Not specified | RECRUITING | Providing Oxygen During Intubation in the NICU Trial |
| NCT06123143 | Not specified | RECRUITING | Flow and Grow - The Ideal Time to Wean CPAP Off In Extremely Low Birth Weight Infants |
| NCT07386041 | Not specified | NOT_YET_RECRUITING | Lung Ultrasound-Guided Respiratory Management in Infants |
| NCT01376544 | Not specified | COMPLETED | Trial of Weaning by Synchronized Ventilation |
| NCT01531010 | Not specified | COMPLETED | Pressure-limited Ventilation Versus Volume-targeted Ventilation in Preterm Newborns |
| NCT01675388 | Not specified | WITHDRAWN | Hypothermia During ECMO to Decrease Brain Injury |
| NCT03154112 | Not specified | COMPLETED | Validation of a Novel Oxygen Consumption Measurement Technique in Neonates |
| NCT03166826 | Not specified | COMPLETED | Development of Modified Combined Apgar Scoring System for Evaluation of Infants in the Delivery Room |
| NCT03591835 | Not specified | COMPLETED | Endotracheal Tube Placement in Neonatal Intubation |
| NCT04640467 | Not specified | UNKNOWN | Prediction of Late Fetal Growth Restriction Using Cerebroplacental Ratio |
| NCT05036603 | Not specified | COMPLETED | Comparison of the Acute Effects of Chest Physiotherapy Methods Applied in Different Positions in Preterm Newborns |
| NCT05081973 | Not specified | UNKNOWN | A Model for Predicting Extubation Success in Premature Babies |
| NCT05127070 | Not specified | UNKNOWN | Evaluating the NeoTree in Malawi and Zimbabwe |
| NCT05194761 | Not specified | UNKNOWN | Normal Saline Nebulization on Prevention of Extubation Failure in Neonates |
| NCT05508308 | Not specified | COMPLETED | Automated Versus Manual Control Of Oxygen For Preterm Infants On Continuous Positive Airway Pressure In Nigeria |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| DEXTROSE | 4 | 1 |
Related Atlas pages
- Drugs: Dextrose