Neoplasm of chest wall

Summary

Neoplasm of chest wall (MONDO:0021388) is a cancer and 12 clinical trials. Top therapeutic interventions include pembrolizumab and sucralfate. A subtype of neoplasm of thorax — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer
• Clinical trials: 12

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	neoplasm of chest wall
Mondo ID	MONDO:0021388
NCIT	C4929
SNOMED CT	126640008
UMLS	C1290309
MedGen	220935
Anatomy (UBERON)	UBERON:0016435
Is cancer (heuristic)	yes

Also known as: chest wall neoplasm · chest wall neoplasm (disease) · chest wall tumor · chest wall tumour · neoplasm of chest wall · neoplasm of the chest wall · tumor of chest wall · tumor of the chest wall · tumour of chest wall · tumour of the chest wall

Disease family

This is a subtype of neoplasm of thorax. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › neoplasm of thorax › neoplasm of chest wall

Related subtypes (10): thoracic benign neoplasm, thoracic cancer, breast neoplasm, lung neoplasm, heart neoplasm, neoplasm of pericardium, neoplasm of mediastinum, neoplasm of aortic body, sternal neoplasm, axillary neoplasm

Subtypes (3): chest wall parachordoma, malignant neoplasm of chest wall, benign neoplasm of chest wall

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 12.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	10
PHASE3	1
PHASE2	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT05369234	PHASE3	COMPLETED	Effects of Oral Aloe Vera Juice on Chemotherapy and Radiation-induced Oral Mucositis and Esophagitis
NCT03971045	PHASE2	RECRUITING	Pembrolizumab and Oral Metronomic Cyclophosphamide in Patients With Chest Wall Breast Cancer
NCT06977022	Not specified	NOT_YET_RECRUITING	Clinical Trial on the Efficacy and Safety of Biodegradable 3D-Printed Implants in Chest Wall Reconstruction Surgery
NCT06978075	Not specified	NOT_YET_RECRUITING	Artificial Intelligence Combined With 3D-Preformed Chest Wall Defection Reconstruction System in Chest Wall Tumor Surgery
NCT06994533	Not specified	NOT_YET_RECRUITING	Comparative Study on Different Bone Reconstruction After Chest Wall Tumor Resection
NCT07018960	Not specified	RECRUITING	Multicenter Registry for Chest Wall Reconstruction Using Custom Dynamic Prostheses (PRODIPET)
NCT07040527	Not specified	NOT_YET_RECRUITING	Comparative Study on Medical Artificial Intelligence Algorithm Assisted and Conventional Imaging Examination Methods
NCT07338006	Not specified	RECRUITING	Chest Wall Reconstruction Cohort
NCT04077710	Not specified	UNKNOWN	RISI in the Treatment of Recurrent Chest Wall Malignancies After EBRT
NCT05057143	Not specified	UNKNOWN	3D Printed Implants for the Defect Reconstruction in Patients With Chest Wall Tumors
NCT07148648	Not specified	COMPLETED	Institutional Experience With Chest Wall Reconstruction Using Sternal Steel Wires: A Case Series Study
NCT07167810	Not specified	COMPLETED	Innovative Approaches to Chest Wall Reconstruction: A Comparative Study of Rigid and Flexible Techniques

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
PEMBROLIZUMAB	4	1
SUCRALFATE	4	1