Neoplasm of mediastinum

Summary

Neoplasm of mediastinum (MONDO:0021386) is a cancer (an umbrella term covering 7 Mondo subtypes) and 16 clinical trials. Top therapeutic interventions include cyclophosphamide anhydrous, doxorubicin, and betamethasone. A subtype of neoplasm of thorax — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer
• Umbrella term: 7 Mondo subtypes
• Clinical trials: 16

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	neoplasm of mediastinum
Mondo ID	MONDO:0021386
NCIT	C3221
SNOMED CT	126725000
UMLS	C0025063
MedGen	44322
Anatomy (UBERON)	UBERON:0003728
Is cancer (heuristic)	yes

Also known as: mediastinal neoplasm · mediastinal tumor · mediastinal tumour · mediastinum neoplasm · mediastinum neoplasm (disease) · mediastinum tumor · mediastinum tumour · neoplasm of mediastinum · neoplasm of the mediastinum · tumor of mediastinum · tumor of the mediastinum · tumour of mediastinum · tumour of the mediastinum

Disease family

This is a subtype of neoplasm of thorax. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › neoplasm of thorax › neoplasm of mediastinum

Related subtypes (10): thoracic benign neoplasm, thoracic cancer, breast neoplasm, lung neoplasm, heart neoplasm, neoplasm of pericardium, neoplasm of chest wall, neoplasm of aortic body, sternal neoplasm, axillary neoplasm

Subtypes (7): mediastinal neural neoplasm, mediastinal granular cell myoblastoma, mediastinal mesenchymal tumor, malignant mediastinum hemangiopericytoma, mediastinal cancer, mediastinal germ cell tumor, benign neoplasm of mediastinum

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 16.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	10
PHASE2	4
PHASE4	1
PHASE3	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00199082	PHASE4	COMPLETED	Newly Diagnosed Mature B-ALL, Burkitt’s Lymphoma and Other High-grade Lymphoma in Adults
NCT03521986	PHASE3	UNKNOWN	Pain and Quality of Life After Mediastinal Tumor Resection by Subxiphoid and Intercostal VATS
NCT05672108	PHASE2	RECRUITING	Phase II Trial of Lung Chemoemobolization
NCT00315211	PHASE2	TERMINATED	Weekly Topotecan With Docetaxel in Recurrent Small Cell Lung Cancer
NCT02499952	PHASE2	TERMINATED	Pembrolizumab in Subjects With Incurable Platinum-Refractory Germ Cell Tumors
NCT05163509	PHASE2	UNKNOWN	MR-linac Guided Adaptive Radiotherapy for Inoperable Mediastinal Tumor
NCT05267496	Not specified	ACTIVE_NOT_RECRUITING	Oscillating Positive Expiratory Pressure Therapy for Patients With Thoracic Neoplasms Undergoing Chest Surgery
NCT05682742	Not specified	ACTIVE_NOT_RECRUITING	Clinical Investigation of the da Vinci Surgical System
NCT06563232	Not specified	NOT_YET_RECRUITING	22G-Adapt Needle Biopsy Versus Fine-needle Aspiration in Endoscopic Ultrasound-guided Sampling of Solid Lesions
NCT07012694	Not specified	NOT_YET_RECRUITING	22G-Adapt vs 22G-Franseen Needle Biopsy in EUS-Guided Tissue Acquisition of Solid Lesions
NCT07065604	Not specified	RECRUITING	Tubeless VATS for Mediastinal Neoplasm
NCT02220231	Not specified	COMPLETED	Echocardiographic Evaluation of the Change on Pulmonary Blood Flow and Cardiac Function Induced by Capnothorax During One Lung Ventilation
NCT03214341	Not specified	UNKNOWN	Assessment of Mediastinal Masses With Diffusion Weighted MR Imaging
NCT03439696	Not specified	COMPLETED	Needlescopic-assisted Uniportal vs Uniportal VATS
NCT03537430	Not specified	COMPLETED	Totally no Tube (TNT) Uniportal Video-assisted Thoracoscopic Surgery (VATS) VS Traditional Uniportal VATS for Mediastinal Tumor
NCT03613272	Not specified	UNKNOWN	The Curative Effect of Extended Thymectomy Performed Through Subxiphoid-right VATS Approach With Elevation of Sternum

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
CYCLOPHOSPHAMIDE ANHYDROUS	4	3
DOXORUBICIN	4	3
BETAMETHASONE	4	1
CYTARABINE	4	1
DEXAMETHASONE	4	1
ETHIODIZED OIL	4	1
ETOPOSIDE PHOSPHATE	4	1
IFOSFAMIDE	4	1
METHOTREXATE	4	1
PREDNISOLONE	4	1
RITUXIMAB	4	1
TOPOTECAN	4	1
VINCRISTINE	4	1
VINDESINE	4	1
CHEMBL426	0	1