Neoplasm of oropharynx

Summary

Neoplasm of oropharynx (MONDO:0021364) is a cancer and 29 clinical trials. Top therapeutic interventions include cisplatin and alpelisib. A subtype of digestive system disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer
• Clinical trials: 29

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	neoplasm of oropharynx
Mondo ID	MONDO:0021364
NCIT	C3291
SNOMED CT	126809003
UMLS	C0029295
MedGen	14519
Anatomy (UBERON)	UBERON:0001729
Is cancer (heuristic)	yes

Also known as: neoplasm of oropharynx · neoplasm of the oropharynx · oropharyngeal neoplasm · oropharyngeal neoplasms · oropharyngeal tumor · oropharyngeal tumour · oropharynx neoplasm · oropharynx neoplasm (disease) · oropharynx tumor · oropharynx tumour · tumor of oropharynx · tumor of the oropharynx · tumour of oropharynx · tumour of the oropharynx

Disease family

This is a subtype of digestive system disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › digestive system disorder › neoplasm of oropharynx

Related subtypes (30): benign digestive system neoplasm, autoimmune disorder of gastrointestinal tract, gastrointestinal mucositis, diarrheal disease, pancreas disorder, hepatobiliary disorder, digestive system cancer, peptic ulcer disease, stomach disorder, intestinal disorder, Meckel diverticulum, Cronkhite-Canada syndrome, diverticulosis, small-intestinal, diverticulosis of bowel, hernia, and retinal detachment, congenital enteropathy due to enteropeptidase deficiency, hereditary mixed polyposis syndrome, caudal duplication, Moyamoya disease with early-onset achalasia, hyperplastic polyposis syndrome, thoraco-abdominal enteric duplication, digestive duplication, juvenile polyposis syndrome, umbilical cord ulceration-intestinal atresia syndrome, growth retardation-mild developmental delay-chronic hepatitis syndrome, common mesentery, gastrointestinal polyp, digestive system neuroendocrine neoplasm, digestive system infectious disorder, upper digestive tract disorder, congenital peritoneal encapsulation

Subtypes (2): oropharynx cancer, benign neoplasm of oropharynx

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 29.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	15
PHASE2	11
PHASE3	2
PHASE1/PHASE2	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00181038	PHASE3	UNKNOWN	Analgesia of Fibula Free Flap Donor Site by Peri-Neuronal Catheter in Oro-Pharyngeal Carcinoma Surgery
NCT01687413	PHASE3	TERMINATED	Post Operative Adjuvant Therapy De-intensification Trial for Human Papillomavirus-related, p16+ Oropharynx Cancer
NCT06167291	PHASE2	ACTIVE_NOT_RECRUITING	Phase II Randomized-registry Embedded Study of Lymphoscintigraphy for Oropharyngeal Neoplasms to Enable Risk-adapted Nodal Guidance for Robotic Surgery and/or Radiotherapy (LONE-RANGR2)
NCT06965738	PHASE2	NOT_YET_RECRUITING	Buccal Fat for Transoral Robotic Lateral Oropharyngectomy Defects to and Postoperative Pain
NCT00251381	PHASE2	UNKNOWN	Cetuximab & Concomitant-Boost Accelerated RT in Patients With Locally Advanced Oropharynx Squamous Cell Carcinoma.
NCT00721799	PHASE2	COMPLETED	F-18 Fluorothymidine PET Imaging for Early Evaluation of Response to Therapy in Head & Neck Cancer Patients
NCT01525927	PHASE2	TERMINATED	Study of Chemotherapy Prior to Radiotherapy and Chemotherapy in Patients With HPV Associated Cancer of the Oral Cavity
NCT01530997	PHASE2	COMPLETED	De-intensification of Radiation & Chemotherapy in Low-Risk Human Papillomavirus-related Oropharyngeal Squamous Cell Ca
NCT02281955	PHASE2	COMPLETED	De-intensification of Radiation and Chemotherapy for Low-Risk HPV-related Oropharyngeal SCC: Follow-up Study
NCT02298595	PHASE1/PHASE2	WITHDRAWN	Cetuximab, Cisplatin and BYL719 for HPV-Associated Oropharyngeal Squamous Cell Carcinoma
NCT02917629	PHASE2	TERMINATED	ACTOplus Met XR in Treating Patients With Stage I-IV Oral Cavity or Oropharynx Cancer Undergoing Definitive Treatment
NCT03077243	PHASE2	COMPLETED	P53 Mutational Status and cf HPV DNA for the Management of HPV-associated OPSCC
NCT04015336	PHASE2	TERMINATED	E7 TCR Cell Induction Immunotherapy for Stage II and Stage III HPV-Associated Oropharyngeal Cancer
NCT04044950	PHASE2	WITHDRAWN	A Phase II Study of Neoadjuvant E7 TCR T Cell Immunotherapy for Borderline Resectable and Unresectable Stage I HPV-Associated Oropharyngeal Cancer
NCT04124198	Not specified	ACTIVE_NOT_RECRUITING	Quality of Life After Primary TORS vs IMRT for Patients With Early-stage Oropharyngeal Squamous Cell Carcinoma
NCT04266093	Not specified	ENROLLING_BY_INVITATION	Gene Therapy Follow up Protocol for Subjects Previously Enrolled in NCI Center for Immuno-Oncology Studies
NCT06642324	Not specified	RECRUITING	Human Papillomavirus Association and Genomic Exploration in Head-Neck Squamous Cell Carcinomas
NCT00918710	Not specified	UNKNOWN	Human Papillomavirus and Oropharynx Carcinoma
NCT01104714	Not specified	COMPLETED	Pharmacogenetic Response to Chemotherapy Induction for ORL Cancers
NCT02045186	Not specified	TERMINATED	Monitoring of Oral Human Papillomavirus Infection (HPV) in HPV-positive Oropharyngeal Squamous Cell Carcinoma (OPSCC)
NCT02262247	Not specified	COMPLETED	A Post-Market Clinical Trial for Access and Visualization of the Oropharynx, Hypopharynx and Larynx During Transoral Procedures
NCT02736786	Not specified	COMPLETED	A Study of Mucosal Sparing Proton Beam Therapy (PBT) in Resected Oropharyngeal Tumors
NCT02792322	Not specified	COMPLETED	Robotic Surgery in the Seated Position for Benign and Malignant Lesions of the Head and Neck
NCT03010813	Not specified	COMPLETED	A Novel Robotic System for Single Port and Natural Orifice Transluminal Endoscopic Surgery
NCT03074110	Not specified	COMPLETED	Isocapnic Hyperventilation - an Alternative Method
NCT03239834	Not specified	COMPLETED	Clinical Evaluation of the OncAlert RAPID in Subjects Presenting for Evaluation and/or Initial Biopsy; Impact on Decision-Making
NCT03942380	Not specified	UNKNOWN	Cell-free Tumor DNA in Head and Neck Cancer Patients
NCT05412628	Not specified	UNKNOWN	Investigating the Association Between Microbiota and Esophageal/Oropharyngeal Cancer
NCT05698667	Not specified	COMPLETED	Outpatient Ultrasound for the Diagnostic Work-up of Oropharynx Cancer

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
CISPLATIN	4	4
ALPELISIB	4	1