Neoplasm of testis

Summary

Neoplasm of testis (MONDO:0021348) is a cancer (an umbrella term covering 8 Mondo subtypes) and 25 clinical trials. Top therapeutic interventions include cisplatin, avelumab, and bleomycin. A subtype of testicular disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer
• Umbrella term: 8 Mondo subtypes
• Clinical trials: 25

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	neoplasm of testis
Mondo ID	MONDO:0021348
NCIT	C3404
SNOMED CT	126900000
UMLS	C0039590
MedGen	52675
Anatomy (UBERON)	UBERON:0000473
Is cancer (heuristic)	yes

Also known as: neoplasm of testis · neoplasm of the testis · testicular neoplasm · testicular tumor · testicular tumour · testis neoplasm · testis neoplasm (disease) · testis tumor · testis tumour · tumor of testis · tumor of the testis · tumour of testis · tumour of the testis

Data availability: 1 cell line.

Disease family

This is a subtype of testicular disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › reproductive system disorder › gonadal disorder › testicular disorder › neoplasm of testis

Related subtypes (7): chylocele of tunica vaginalis, atrophy of testis, testicular infarct, testicular dysgenesis syndrome, orchitis, spermatic cord torsion, acquired testicular failure

Subtypes (8): seminal vesicle tumor, testicular Brenner tumor, testicular sex cord-stromal neoplasm, rete testis neoplasm, testicular cancer, testicular germ cell tumor, benign neoplasm of testis, childhood testicular neoplasm

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 25.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	16
PHASE2	6
PHASE1	2
PHASE3	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT02341989	PHASE3	ACTIVE_NOT_RECRUITING	Adjuvant Bleomycin, Etoposide and Cisplatin (BEP) Versus Carboplatin in Stage I Seminomatous Testicular Cancer
NCT00123773	PHASE2	COMPLETED	Study of F-Fluorodeoxyglucose (FluGlucoScan) in Patients With Known or Suspected Cancers of Low Incidence
NCT00231582	PHASE2	COMPLETED	High-dose Chemotherapy With Autologous Stem Cell Transplantation in Poor Prognosis Germ-cell Tumors: TAXIF II
NCT02161692	PHASE2	COMPLETED	Conventional Dose Versus High Dose Sequential Chemotherapy for Poor Prognosis Germ Cell Tumors
NCT02499952	PHASE2	TERMINATED	Pembrolizumab in Subjects With Incurable Platinum-Refractory Germ Cell Tumors
NCT03403777	PHASE2	COMPLETED	Avelumab in Refractory Testicular Germ Cell Cancer.
NCT06309732	PHASE2	COMPLETED	GAMEC-II, Risk-adapted Protocol for Relapsed Germ Cell Tumours (GCT)
NCT00001270	PHASE1	COMPLETED	Feasibility Study of Interleukin 1-Alpha With Ifosfamide, CBDCA, and Etoposide With Autologous Bone Marrow Transplant in Metastatic Carcinoma and Lymphoma
NCT05229900	PHASE1	TERMINATED	A Study of SGN-ALPV in Advanced Solid Tumors
NCT02099734	Not specified	RECRUITING	Germ Cell Tumor and Testicular Tumor DNA Registry
NCT02229916	Not specified	RECRUITING	Swiss Austrian German Testicular Cancer Cohort Study - SAG TCCS
NCT05264337	Not specified	RECRUITING	Lymphedema After Urologic Surgery
NCT02304575	Not specified	UNKNOWN	Quality of Life Among Testicular Cancer Survivors
NCT02459132	Not specified	COMPLETED	High-Intensity Aerobic Interval Training in Testicular Cancer Survivors
NCT02492360	Not specified	WITHDRAWN	Establishing of Neuronal-like Cells From Patients With Cisplatin-Induced Peripheral Neuropathy
NCT02577172	Not specified	TERMINATED	Testicular Cancer and Aerobic and Strength Training
NCT02890030	Not specified	COMPLETED	The Platinum Study Comparison Group
NCT02900248	Not specified	TERMINATED	CureOne Registry: Advanced Malignancy or Myelodysplasia, Tested by Standard Sequencing and Treated by Physician Choice
NCT02966509	Not specified	COMPLETED	Engagement of Patients With Advanced Cancer
NCT03426865	Not specified	COMPLETED	Role of Axumin PET Scan in Germ Cell Tumor
NCT03436901	Not specified	COMPLETED	Whole Body MRI With DWI for Monitoring Patients Treated for Testicular Cancer Stage II-III
NCT04122430	Not specified	COMPLETED	Risk of Venous Thromboembolism in Patients Receiving First-Line Chemotherapy for Disseminated Germ Cell Tumours
NCT04531709	Not specified	COMPLETED	Financial Toxicity and Quality of Life in Patients With TGCT
NCT05056688	Not specified	COMPLETED	Effect of Online Education Given to Young Adults on Testicular Cancer Health Beliefs and Behaviors
NCT06044220	Not specified	COMPLETED	Testicular Self-examination Training Given to Students

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
CISPLATIN	4	3
AVELUMAB	4	1
BLEOMYCIN	4	1
DACTINOMYCIN	4	1
CHEMBL4748391	0	1