Nerve compression syndrome

Summary

Nerve compression syndrome (MONDO:0003615) is a disease and 16 clinical trials. A subtype of peripheral neuropathy — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 16

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	nerve compression syndrome
Mondo ID	MONDO:0003615
EFO	EFO:0009487
MeSH	D009408
DOID	DOID:573
NCIT	C27221
SNOMED CT	45781009
UMLS	C1510429
MedGen	266933
Is cancer (heuristic)	no

Also known as: entrapment neuropathy

Disease family

This is a subtype of peripheral neuropathy. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › nervous system disorder › peripheral nervous system disorder › peripheral neuropathy › nerve compression syndrome

Related subtypes (29): autoimmune neuropathy, autonomic neuropathy, mononeuropathy, ischemic neuropathy, polyneuropathy, neuritis, motor peripheral neuropathy, sensory peripheral neuropathy, uremic neuropathy, axonal neuropathy, diabetic neuropathy, acquired peripheral neuropathy, hereditary peripheral neuropathy, neuralgia, peripheral nerve lesion, nerve plexus disorder, traumatic neuropathy, radiation-induced neuropathy, vasculitic neuropathy, chronic idiopathic neuropathy, chemotherapy-induced neuropathy, infectious neuropathy, vitamin deficiency related neuropathy, paraproteinemia-associated neuropathy, neuropathy in cryoglobulinemia, neuropathy in endocrine disorder, sarcoid neuropathy, neuropathy, small fiber, idiopathic small fibers neuropathy

Subtypes (3): carpal tunnel syndrome, meralgia paresthetica, piriformis syndrome

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 16.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	15
PHASE2/PHASE3	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00220675	PHASE2/PHASE3	TERMINATED	Erythropoietin Spinal Cord Compression Randomized Trial
NCT07508397	Not specified	NOT_YET_RECRUITING	Median Nerve Cross-Sectional Area and Body Weight in Carpal Tunnel Syndrome
NCT00775333	Not specified	COMPLETED	Nerve Entrapment in Diabetic Patients
NCT00856011	Not specified	COMPLETED	Nerve Morphology in Diabetic Patients
NCT01753778	Not specified	COMPLETED	Study Evaluating Treatment of Forefoot Pain Related to Nerve Entrapment Using the Cryo-Touch III Device
NCT02318381	Not specified	COMPLETED	Suprascapular Neuropathy in the Setting of Rotator Cuff Tears: Results of Arthroscopic Treatment
NCT02429947	Not specified	COMPLETED	An Analysis of the Symptomatic Domains Most Relevant to Charcot Marie Tooth Neuropathy (CMT) Patients
NCT03062722	Not specified	COMPLETED	Efficacy of Keyhole Approach to Carpal Tunnel Syndrome Under Ambulatory Strategy
NCT03651609	Not specified	COMPLETED	Treatment for Ulnar Neuropathy at the Elbow
NCT04014244	Not specified	UNKNOWN	Dextrose, Corticosteroids and Surgical Release in Carpal Tunnel Syndrome
NCT04949373	Not specified	COMPLETED	High Intensity Laser Therapy in Carpal Tunnel Syndrome
NCT05080452	Not specified	UNKNOWN	Visualizing ACNES and LUCNES With DIRT
NCT05233488	Not specified	UNKNOWN	Effect of Different Ultrasound Doses on Median Nerve Conduction Parameters
NCT05307354	Not specified	COMPLETED	The Effectiveness of Tibial Nerve Mobilization in Patients With Tarsal Tunnel Syndrome
NCT06400433	Not specified	COMPLETED	Comparing Efficacies of Median Nerve Hydrodissection With Dexamethasone and Dextrose in Carpal Tunnel Syndrome
NCT07408596	Not specified	COMPLETED	Ultrasound Measures and Clinical Outcomes in Healthy Individuals, Mild and Moderate Carpal Tunnel Syndrome Patients