Nervous system neoplasm
disease diseaseOn this page
Also known as neoplasm of nervous systemneoplasm of the nervous systemnervous system neoplasm (disease)nervous system neoplasmsnervous system tumornervous system tumourtumor of nervous systemtumor of the nervous systemtumour of nervous systemtumour of the nervous system
Summary
Nervous system neoplasm (MONDO:0021248) is a cancer (an umbrella term covering 7 Mondo subtypes) and 8 clinical trials. Top therapeutic interventions include armodafinil and veliparib. A subtype of neoplasm — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Classification: Cancer
- Umbrella term: 7 Mondo subtypes
- Clinical trials: 8
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | nervous system neoplasm |
| Mondo ID | MONDO:0021248 |
| NCIT | C3268 |
| UMLS | C0027766 |
| MedGen | 45046 |
| Anatomy (UBERON) | UBERON:0001016 |
| Is cancer (heuristic) | yes |
Also known as: neoplasm of nervous system · neoplasm of the nervous system · nervous system neoplasm (disease) · nervous system neoplasms · nervous system tumor · nervous system tumour · tumor of nervous system · tumor of the nervous system · tumour of nervous system · tumour of the nervous system
Disease family
This is a subtype of neoplasm. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › nervous system neoplasm
Related subtypes (47): pre-malignant neoplasm, endocrine gland neoplasm, giant cell tumor, hematopoietic and lymphoid system neoplasm, skin neoplasm, mesenchymal cell neoplasm, epidural spinal canal neoplasm, skeletal muscle neoplasm, trophoblastic neoplasm, cancer, germ cell tumor, benign neoplasm, upper aerodigestive tract neoplasm, histiocytoma, embryonal neoplasm, head and neck neoplasm, epithelial neoplasm, reproductive system neoplasm, non-seminomatous lesion, odontogenic cyst, phosphaturic mesenchymal tumor, thyroglossal duct cyst, hamartoma, mesenchymoma, mesothelial neoplasm, peritoneal neoplasm, virus associated tumor, nail tumor, respiratory tract neoplasm, spindle cell neoplasm, mixed neoplasm, urinary system neoplasm, cystic neoplasm, childhood neoplasm, melanocytic neoplasm, digestive system neoplasm, neoplasm of thorax, connective tissue neoplasm, bronchial adenomas/carcinoids childhood, diffuse idiopathic pulmonary neuroendocrine cell hyperplasia, erythroplakia, retroperitoneal neoplasm, cardiovascular neoplasm, dermoid or epidermoid cyst of the central nervous system, connective and soft tissue neoplasm, NTRK fusion positive cancer, RET fusion positive cancer
Subtypes (7): nervous system benign neoplasm, peripheral nervous system neoplasm, nervous system cancer, central nervous system neoplasm, tumor of cranial and spinal nerves, neuroepithelial neoplasm, retina neoplasm
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 8.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| PHASE1 | 4 |
| Not specified | 3 |
| PHASE2 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT01032200 | PHASE2 | COMPLETED | Armodafinil in Treating Fatigue Caused By Radiation Therapy in Patients With Primary Brain Tumors |
| NCT03911388 | PHASE1 | RECRUITING | HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors |
| NCT05746104 | PHASE1 | ENROLLING_BY_INVITATION | Second Window Indocyanine Green for All Nervous System Tumors |
| NCT00437372 | PHASE1 | COMPLETED | Phase IB Study Using Sunitinib Plus Radiation Therapy for Cancer Patients |
| NCT00649207 | PHASE1 | COMPLETED | A Phase I Study of ABT-888 in Combination With Conventional Whole Brain Radiation Therapy (WBRT) in Cancer Patients With Brain Metastases |
| NCT04516720 | Not specified | RECRUITING | Creation of a Clinical Database on Primary Nervous System Tumors |
| NCT01579253 | Not specified | UNKNOWN | Combined O-(2-[18F]Fluoroethyl)-L-tyrosine (FET) Positron Emission Tomography (PET) and Simultaneous Magnetic Resonance Imaging (MRI) Follow-up in Re-irradiated Recurrent Glioblastoma Patients |
| NCT02450019 | Not specified | COMPLETED | Protective Ventilation in Neurosurgery, a Pilot Study |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| ARMODAFINIL | 4 | 1 |
| VELIPARIB | 3 | 1 |
| CHEMBL275117 | 0 | 1 |
Related Atlas pages
- Drugs: Armodafinil, Veliparib