Neuralgia

Summary

Neuralgia (MONDO:0021667) is a disease (an umbrella term covering 5 Mondo subtypes) and 142 clinical trials. Top therapeutic interventions include pregabalin, amitriptyline, and capsaicin. A subtype of peripheral neuropathy — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Umbrella term: 5 Mondo subtypes
• Clinical trials: 142

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	neuralgia
Mondo ID	MONDO:0021667
EFO	EFO:0009430
MeSH	D009437
SNOMED CT	16269008
UMLS	C0027796
MedGen	18010
Is cancer (heuristic)	no

Also known as: neuralgia · pain, nerve · pain, neuropathic · paroxysmal nerve pain · paroxysmal nerve pains

Disease family

This is a subtype of peripheral neuropathy. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › nervous system disorder › peripheral nervous system disorder › peripheral neuropathy › neuralgia

Related subtypes (29): autoimmune neuropathy, autonomic neuropathy, mononeuropathy, ischemic neuropathy, polyneuropathy, neuritis, motor peripheral neuropathy, sensory peripheral neuropathy, uremic neuropathy, nerve compression syndrome, axonal neuropathy, diabetic neuropathy, acquired peripheral neuropathy, hereditary peripheral neuropathy, peripheral nerve lesion, nerve plexus disorder, traumatic neuropathy, radiation-induced neuropathy, vasculitic neuropathy, chronic idiopathic neuropathy, chemotherapy-induced neuropathy, infectious neuropathy, vitamin deficiency related neuropathy, paraproteinemia-associated neuropathy, neuropathy in cryoglobulinemia, neuropathy in endocrine disorder, sarcoid neuropathy, neuropathy, small fiber, idiopathic small fibers neuropathy

Subtypes (5): cranial neuralgia, familial episodic pain syndrome, pudendal neuralgia, post-infectious neuralgia, sciatica

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

6 approved, 14 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.

Drug	Development status
Capsaicin	Approved (phase 4)
Clonidine	Approved (phase 4)
Gabapentin	Approved (phase 4)
Gabapentin Enacarbil	Approved (phase 4)
Lidocaine	Approved (phase 4)
Pregabalin	Approved (phase 4)
Amitriptyline	Phase 3 (in late-stage trials)
Buprenorphine	Phase 3 (in late-stage trials)
Crisugabalin	Phase 3 (in late-stage trials)
Dexamethasone	Phase 3 (in late-stage trials)
Ketamine	Phase 3 (in late-stage trials)
Methadone	Phase 3 (in late-stage trials)
Mirogabalin	Phase 3 (in late-stage trials)
Nabiximols	Phase 3 (in late-stage trials)
Onabotulinumtoxina	Phase 3 (in late-stage trials)
Oxcarbazepine	Phase 3 (in late-stage trials)
Paroxetine	Phase 3 (in late-stage trials)
Poloxamer	Phase 3 (in late-stage trials)
Tapentadol	Phase 3 (in late-stage trials)
Tramadol	Phase 3 (in late-stage trials)

Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Acetaminophen, Acetylcysteine, Ascorbic Acid, Cannabidiol, Celecoxib, Cetuximab, Dextromethorphan, Donepezil, Dronabinol, Duloxetine, Ergocalciferol, Esomeprazole, Ethosuximide, Human Immunoglobulin G, Lacosamide, Losmapimod, Loxapine, Magnesium Sulfate Anhydrous, Memantine, Milnacipran, Minocycline, Morphine, Nabilone, Naloxone, Naproxen, Nitric Oxide, Oxycodone, Oxytocin, Perampanel, Ralfinamide, Sodium Chloride, Telmisartan, Terbutaline, Valproic Acid, Vixotrigine.

Clinical trials & evidence

Clinical trials

Clinical trials: 142.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	73
PHASE2	24
PHASE3	17
PHASE4	10
PHASE1	6
PHASE2/PHASE3	5
PHASE1/PHASE2	4
EARLY_PHASE1	3

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00292188	PHASE4	COMPLETED	P4 (Pregabalin for Peripheral Posttraumatic Pain)
NCT01264237	PHASE4	UNKNOWN	Evaluation of the Efficacy, Tolerability and Safety of Etoricoxib (Arcoxia) in Patients With Neuropathic Pain
NCT01298466	PHASE4	WITHDRAWN	Primary Care Identification Of Patients With Chronic Neuropathic Low Back Pain Study
NCT02180880	PHASE4	COMPLETED	Symptom Based Treatment of Neuropathic Pain
NCT02616523	PHASE4	COMPLETED	Influence of Dexmedetomidine and Lidocaine on Opioid Consumption in Laparoscopic Intestine Resection
NCT02862769	PHASE4	UNKNOWN	Intra-operative Lidocaine Infusion in Preventing CPSP Post VATs
NCT03244540	PHASE4	COMPLETED	Regional Analgesia After Cesarean Section
NCT03280017	PHASE4	COMPLETED	Ketamine With Multilevel Paravertebral Block for Post Video-assisted Thoracic Surgery Pain
NCT03723447	PHASE4	COMPLETED	Intraoperative TAP Block With Bupivacaine/Dexamethasone Against Liposomal Bupivacaine (Exparel®)
NCT04653792	PHASE4	COMPLETED	Role Of Pregabalin To Decrease Postoperative Pain In Microdiscectomy
NCT04299893	PHASE2/PHASE3	RECRUITING	Ozone Therapy in Chemotherapy-induced Peripheral Neuropathy: RCT (O3NPIQ)
NCT06185816	PHASE2/PHASE3	RECRUITING	Non-Invasive Pulsed Radiofrequency for the Treatment of Neuropathic Pain
NCT00061776	PHASE2/PHASE3	COMPLETED	NGX-4010 for the Treatment of Postherpetic Neuralgia
NCT00068081	PHASE3	COMPLETED	Controlled Study of NGX-4010 for the Treatment of Postherpetic Neuralgia
NCT00115310	PHASE3	COMPLETED	Study of NGX-4010 for the Treatment of Postherpetic Neuralgia
NCT00134524	PHASE3	UNKNOWN	The Effects of the Magnetic Molecular Energizer (MME) on Diabetic Peripheral Neuropathy
NCT00141219	PHASE3	COMPLETED	Pregabalin Peripheral Neuropathic Pain Study
NCT00150436	PHASE3	COMPLETED	To Evaluate Long-Term Safety and Efficacy of Pregabalin in Patients With Postherpetic Neuralgia.
NCT00221637	PHASE2/PHASE3	TERMINATED	Efficacy of Valproate in Peripheral Neuropathic Pain
NCT00224588	PHASE3	COMPLETED	KETOR: Effects of Peri Operative Administration of Ketamine on Long Term Post Thoracotomy Pain
NCT00300222	PHASE3	COMPLETED	Study of NGX-4010 for the Treatment of Postherpetic Neuralgia
NCT00407745	PHASE3	COMPLETED	A 17-Week Trial To Assess Pregabalin For The Treatment Of Nerve Pain Due To Spinal Cord Injury
NCT00592904	PHASE2/PHASE3	COMPLETED	Evaluating E2007 (Perampanel) in Patients With Painful Diabetic Neuropathy (PDN) or Post-Herpetic Neuralgia (PHN)
NCT00631943	PHASE3	COMPLETED	A Study to Evaluate the Efficacy and Safety of Pregabalin (Lyrica) for the Treatment of Nerve Pain
NCT00740571	PHASE3	UNKNOWN	Amitriptyline or Pregabalin to Treat Neuropathic Pain in Incurable Cancer
NCT00944502	PHASE3	UNKNOWN	To Evaluate the Efficacy and Tolerability of the Use of Vitatonus Dexa Compared to Dexamethasone in Patients With Neuralgia of Various Origins
NCT01202227	PHASE3	COMPLETED	An Open-Label Long-Term Study Of Pregabalin For The Treatment Of Central Neuropathic Pain
NCT03009500	PHASE3	COMPLETED	Randomized Controlled Trial of Efficacy and Safety of Local Anesthetics and Steroids for Chronic Peripheral Post-traumatic Neuropathic Pain
NCT03324035	PHASE3	UNKNOWN	Treatment of Neuropathic Pain in Leprosy
NCT03513822	PHASE3	UNKNOWN	Ketamine’s Efficiency in the Treatment of Chronic Pain: Kynurenin Pathway
NCT03747562	PHASE3	WITHDRAWN	Study of Efficacy and Safety of Gabapentin to Reduce the Need for Strong Opioid Use in Head and Neck Cancer Patients.
NCT03928093	PHASE3	COMPLETED	Pregabalin Treatment for RDEB Pain and Itch
NCT05864053	PHASE1/PHASE2	RECRUITING	(2R,6R)-Hydroxynorketamine for the Treatment of Neuropathic Pain
NCT00001344	PHASE2	COMPLETED	Dextromethorphan Versus Placebo for Neuropathic Pain
NCT00034710	PHASE2	COMPLETED	Pilot Study of High-Dose Capsaicin Patches to Treat Postherpetic Neuralgia Pain
NCT00082316	PHASE2	COMPLETED	Tolerability of Three Local Anesthetic Formulations in Conjunction With NGX-4010 for the Treatment of Neuropathic Pain
NCT00089557	PHASE2	TERMINATED	An Open-Label Extension Study of NGX-4010 for the Treatment of Neuropathic Pain
NCT00099528	PHASE2	UNKNOWN	Dose-Finding Study of REN-1654 in Patients With Post-Herpetic Neuralgia
NCT00233155	PHASE2	COMPLETED	Study of NGX-4010 for the Treatment of Painful HIV-Associated Neuropathy (HIV-AN) or Postherpetic Neuralgia (PHN)
NCT00390845	PHASE2	COMPLETED	P38 Mitogen-activated Protein (Map) Kinase Inhibitor (SB-681323)Study In Patients With Neuropathic Pain

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
PREGABALIN	4	15
AMITRIPTYLINE	4	6
CAPSAICIN	4	3
DEXTROMETHORPHAN	4	3
VALPROIC ACID	4	3
PERAMPANEL	4	2
CARBAMAZEPINE	4	1
DICLOFENAC SODIUM	4	1
DIPYRONE	4	1
EPINEPHRINE	4	1
ETORICOXIB	4	1
FENTANYL	4	1
HYALURONIDASE	4	1
KETOPROFEN	4	1
LITHIUM CARBONATE	4	1
OXCARBAZEPINE	4	1
OXYGEN	4	1
TAPENTADOL	4	1
CARISBAMATE	3	1
FULRANUMAB	3	1
INSULIN, ISOPHANE	3	1
LOSMAPIMOD	3	1
OZONE	3	1
SYRUP	3	1
ZUCAPSAICIN	3	1
DILMAPIMOD	2	1
GRT-6010	2	1
RACEPINEPHRINE	2	1
CUNERMUSPIR	1	1
HYDROXYNORKETAMINE, (2R,6R)	1	1