Neuritis

Summary

Neuritis (MONDO:0002122) is a disease (an umbrella term covering 7 Mondo subtypes) and 8 clinical trials. Top therapeutic interventions include dolutegravir, methotrexate, and methylprednisolone. A subtype of peripheral neuropathy — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Umbrella term: 7 Mondo subtypes
• Clinical trials: 8

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	neuritis
Mondo ID	MONDO:0002122
MeSH	D009443
DOID	DOID:1803
NCIT	C116381
SNOMED CT	128192007, 84299009
UMLS	C0027813
MedGen	14344
Is cancer (heuristic)	no

Also known as: nerve inflammation

Disease family

This is a subtype of peripheral neuropathy. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › nervous system disorder › peripheral nervous system disorder › peripheral neuropathy › neuritis

Related subtypes (29): autoimmune neuropathy, autonomic neuropathy, mononeuropathy, ischemic neuropathy, polyneuropathy, motor peripheral neuropathy, sensory peripheral neuropathy, uremic neuropathy, nerve compression syndrome, axonal neuropathy, diabetic neuropathy, acquired peripheral neuropathy, hereditary peripheral neuropathy, neuralgia, peripheral nerve lesion, nerve plexus disorder, traumatic neuropathy, radiation-induced neuropathy, vasculitic neuropathy, chronic idiopathic neuropathy, chemotherapy-induced neuropathy, infectious neuropathy, vitamin deficiency related neuropathy, paraproteinemia-associated neuropathy, neuropathy in cryoglobulinemia, neuropathy in endocrine disorder, sarcoid neuropathy, neuropathy, small fiber, idiopathic small fibers neuropathy

Subtypes (7): neuroretinitis, mononeuritis simplex, neuritis of upper limb, motor nerve neuritis, vestibular neuronitis, brachial plexus neuritis, polyneuritis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 8.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	4
PHASE4	2
PHASE2	2

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00037115	PHASE4	WITHDRAWN	Induction Therapy With a Single High Dose Bolus of Intravenous Methotrexate With Leucovorin Rescue, Prior to Initiation of AVONEX® Treatment, in Patients Presenting With a First Acute Demyelinating Event.
NCT03247413	PHASE4	TERMINATED	Post-lesion Administration of Dexamethasone to Prevent the Development of Neuritis After Radiofrequency Ablation
NCT07555431	PHASE2	NOT_YET_RECRUITING	Dolutegravir Versus Dolutegravir in Combination With Tenofovir for the Treatment of HTLV-1 Infection
NCT00772525	PHASE2	COMPLETED	Single Oral Doses Study of Nerispirdine on Visual Function in Patients With Multiple Sclerosis
NCT04448938	Not specified	RECRUITING	RESting-state Functional MRI in Patients With Optic Neuritis for ANticipation of reCovEry
NCT02107417	Not specified	UNKNOWN	Study of TENS in Reducing Symptoms of Peripheral Neuropathy Induced by Chemotherapy
NCT03493321	Not specified	UNKNOWN	Role of PRF With MTA and Theracal After Pulpotomy in Relieving Pain
NCT05095844	Not specified	UNKNOWN	National Vaccine Adverse Event Reporting Survey and Etiology

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
DOLUTEGRAVIR	4	1
METHOTREXATE	4	1
METHYLPREDNISOLONE	4	1
INTERFERON BETA	3	1
NERISPIRDINE	2	1
CHEMBL426	0	1