Neurogenic bowel
diseaseOn this page
Summary
Neurogenic bowel (MONDO:0006868) is a disease and 28 clinical trials. Top therapeutic interventions include glycopyrronium. A subtype of intestinal disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 28
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | neurogenic bowel |
| Mondo ID | MONDO:0006868 |
| MeSH | D055496 |
| DOID | DOID:13419 |
| SNOMED CT | 425671009 |
| UMLS | C0695242 |
| MedGen | 151969 |
| MedDRA | 10048657 |
| Is cancer (heuristic) | no |
Disease family
This is a subtype of intestinal disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › digestive system disorder › intestinal disorder › neurogenic bowel
Related subtypes (57): intestinal atresia, steatorrhea, angiodysplasia of intestine, endometriosis of intestine, hypertrophic pyloric stenosis, mucocele of appendix, gastroenteritis, diverticulitis, intestinal obstruction, postgastrectomy syndrome, chronic intestinal vascular insufficiency, bowel dysfunction, irritable bowel syndrome, Whipple disease, inflammatory bowel disease, intestinal polyp, necrotizing enterocolitis, intestinal perforation, pneumatosis cystoides intestinalis, volvulus of midgut, abetalipoproteinemia, aplasia cutis congenita-intestinal lymphangiectasia syndrome, trichohepatoenteric syndrome, protein-losing enteropathy, chronic diarrhea with villous atrophy, Satoyoshi syndrome, glucose-galactose malabsorption, congenital diarrhea 7 with exudative enteropathy, chronic atrial and intestinal dysrhythmia, congenital enterocyte heparan sulfate deficiency, short bowel syndrome, intractable diarrhea-choanal atresia-eye anomalies syndrome, solitary rectal ulcer syndrome, NK-cell enteropathy, chronic intestinal failure, intestinal lymphangiectasia, refractory celiac disease, eosinophilic gastrointestinal disease, cryptogenic multifocal ulcerous stenosing enteritis, chronic enteropathy associated with SLCO2A1 gene, cytosolic phospholipase-A2 alpha deficiency associated bleeding disorder, malakoplakia, malabsorption syndrome, ischemic bowel disorder, intestinal neoplasm, intestinal motility disease, 4-hydroxyphenylacetic aciduria, parasitic intestinal disorder, Aeromonas hydrophila intestinal disease, large intestine disorder, small intestine disorder, primary desmosis coli, isolated mesenteric vein thrombosis, collagenous sprue, visceral leiomyopathy, African degenerative, intestinal dysmotility syndrome, intestinal fistula
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 28.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 20 |
| EARLY_PHASE1 | 3 |
| PHASE3 | 2 |
| PHASE1 | 2 |
| PHASE4 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT02435069 | PHASE4 | COMPLETED | A Within Subjects Comparison of Two Antegrade Flushing Regimens in Children |
| NCT06351995 | PHASE3 | ACTIVE_NOT_RECRUITING | Neostigmine and Glycopyrrolate by Iontophoresis |
| NCT03987126 | PHASE3 | COMPLETED | Prebiotics for Spinal Cord Injury Patients With Bowel and Bladder Dysfunction |
| NCT02370433 | PHASE1 | UNKNOWN | Use of Prokinetics During Inpatient Bowel Care for SCI Patients |
| NCT04671030 | PHASE1 | COMPLETED | Use of a Prokinetic Agent as an Adjunct to Thrice Weekly Bowel Care After SCI |
| NCT02370862 | EARLY_PHASE1 | COMPLETED | Transdermal Administration of a Prokinetic Agent for Bowel Evacuation in Persons With SCI |
| NCT04027972 | EARLY_PHASE1 | COMPLETED | Pharmacokinetics of Neostigmine and Glycopyrrolate |
| NCT06351852 | EARLY_PHASE1 | COMPLETED | Transdermal Administration by a Novel Wireless Iontophoresis Device |
| NCT04707976 | Not specified | RECRUITING | Comparing Transanal Irrigation With Navina Smart vs. Standard Bowel Care in Patients With Multiple Sclerosis |
| NCT06333886 | Not specified | ACTIVE_NOT_RECRUITING | Use of Point-of-care Neuro-sacral Electrophysiology Following Spinal Cord Injury |
| NCT06345781 | Not specified | RECRUITING | Abdominal Functional Electrical Stimulation to Improve Bowel Function in Spinal Cord Injury |
| NCT06515223 | Not specified | RECRUITING | Improving Pelvic Rehabilitation Using Epidural Stimulation After Spinal Cord Injury |
| NCT06801431 | Not specified | NOT_YET_RECRUITING | Transcutaneous Spinal Cord Stimulation for Bowel Management in Individuals with Motor Complete Spinal Cord Injury |
| NCT07390318 | Not specified | RECRUITING | Bowel Continence Across the Lifespan in People With Spina Bifida |
| NCT01920243 | Not specified | COMPLETED | Evaluation of a Bowel and Bladder Health Management Program for Individuals With Spinal Cord Injury (SCI) |
| NCT02406859 | Not specified | COMPLETED | Utility of an Animated Bowel Biofeedback Training Routine to Improve Bowel Function in Individuals With SCI |
| NCT02709395 | Not specified | COMPLETED | Evaluation of a Novel Electronic Transanal Irrigation System - Navina™ Smart |
| NCT02979808 | Not specified | COMPLETED | An Open, Qualitative, Prospective, Multicenter Trial of a Novel Transanal Irrigation System in Spinal Cord Injured Patients. |
| NCT03458871 | Not specified | COMPLETED | Home Neuromodulation of the Neurogenic Bladder in Chronic Spinal Cord Injury With Transcutaneous Tibial Nerve Stimulation |
| NCT03949660 | Not specified | UNKNOWN | Improving Bowel Function and Quality of Life After Spinal Cord Injury |
| NCT04307303 | Not specified | COMPLETED | Electrical Stimulation of Abdominal Muscles for Bowel Management in People With Spinal Cord Injury |
| NCT04604951 | Not specified | UNKNOWN | Below the Belt: Non-invasive Neuromodulation to Treat Bladder, Bowel, and Sexual Dysfunction Following Spinal Cord Injury |
| NCT04726059 | Not specified | UNKNOWN | Motor & Autonomic Concomitant Health Improvements With Neuromodulation & Exercise Training: An SCI RCT |
| NCT04815226 | Not specified | UNKNOWN | The Role of Active Administration of Peristeen Bowel Evacuation for the Management of Urinary Tract Infection |
| NCT05176327 | Not specified | COMPLETED | Exoskeleton Neurogenic Bowel Dysfunction Study |
| NCT05351138 | Not specified | COMPLETED | Comparison of Transcutaneous Electrical Nerve Stimulation and Manual Therapy in Children With Cerebral Palsy |
| NCT05381610 | Not specified | TERMINATED | A Clinical Investigation Evaluating Peristeen® Performance |
| NCT05688644 | Not specified | UNKNOWN | Sacral Neuromodulation in Neurogenic Patients |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| GLYCOPYRRONIUM | 4 | 16 |
Related Atlas pages
- Drugs: Glycopyrronium