Neurogenic thoracic outlet syndrome

Summary

Neurogenic thoracic outlet syndrome (MONDO:0015061) is a disease and 2 clinical trials. A subtype of thoracic outlet syndrome — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: Unknown (Worldwide)
• Phenotypes (HPO): 8
• Clinical trials: 2

Clinical features

Signs & symptoms

Clinical features (HPO)

8 HPO clinical features (Orphanet curated; top 8 by frequency):

HPO ID	Term	Frequency
HP:0002829	Arthralgia	Very frequent (80-99%)
HP:0003326	Myalgia	Very frequent (80-99%)
HP:0003401	Paresthesia	Very frequent (80-99%)
HP:0003457	EMG abnormality	Very frequent (80-99%)
HP:0012534	Dysesthesia	Very frequent (80-99%)
HP:0000772	Abnormal rib morphology	Frequent (30-79%)
HP:0000763	Sensory neuropathy	Occasional (5-29%)
HP:0001324	Muscle weakness	Occasional (5-29%)

Identifiers

Disease identifiers

Field	Value
Canonical name	neurogenic thoracic outlet syndrome
Mondo ID	MONDO:0015061
Orphanet	100073
SNOMED CT	2040007
UMLS	C0751549
MedGen	155880
GARD	0019749
Is cancer (heuristic)	no

Also known as: neurogenic cervical rib syndrome · neurogenic costoclavicular syndrome · neurogenic thoracic outlet compression syndrome · neurogenic TOS · NTOS

Disease family

This is a subtype of thoracic outlet syndrome. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › syndromic disease › thoracic outlet syndrome › neurogenic thoracic outlet syndrome

Related subtypes (2): arterial thoracic outlet syndrome, venous thoracic outlet syndrome

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 2.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	2

Top trials by phase / activity

NCT	Phase	Status	Title
NCT06172101	Not specified	RECRUITING	Free Fat Flap In Recurrent Neurogenic Thoracic Outlet Syndrome Surgical Treatment
NCT03748602	Not specified	UNKNOWN	Surgical Thoracic Outlet Decompression for Neurogenic Thoracic Outlet Syndrome