Neuronitis

Summary

Neuronitis (MONDO:0004466) is a disease and 18 clinical trials. Top therapeutic interventions include celecoxib, rutin, and withanolide d. A subtype of nervous system disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 18

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	neuronitis
Mondo ID	MONDO:0004466
DOID	DOID:8117
NCIT	C34847
UMLS	C0027881
MedGen	45064
Is cancer (heuristic)	no

Also known as: neuroinflammation

Disease family

This is a subtype of nervous system disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › nervous system disorder › neuronitis

Related subtypes (71): congenital nervous system disorder, central nervous system disorder, autoimmune disorder of the nervous system, cranial nerve neuropathy, peripheral nervous system disorder, diplegia of upper limb, retinal disorder, developmental disability, restless legs syndrome, movement disorder, toxic encephalopathy, Barre-Lieou syndrome, Gerstmann syndrome, drug-induced akathisia, drug-induced dyskinesia, stiff-person syndrome, Worster-Drought syndrome, corneal-cerebellar syndrome, pachygyria-intellectual disability-epilepsy syndrome, porencephaly-cerebellar hypoplasia-internal malformations syndrome, symmetrical thalamic calcifications, neonatal brainstem dysfunction, primary orthostatic hypotension, rippling muscle disease with myasthenia gravis, periodic paralysis, qualitative or quantitative protein defects in neuromuscular diseases, specific learning disability, cerebellar hypoplasia-tapetoretinal degeneration syndrome, locked-in syndrome, dopa-responsive dystonia, idiopathic recurrent stupor, chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids, spontaneous periodic hypothermia, Sydenham chorea, duplication of the pituitary gland, Balint syndrome, paraneoplastic neurologic syndrome, persistent idiopathic facial pain, serotonin syndrome, hypothalamic adipsic hypernatraemia syndrome, exercise-induced malignant hyperthermia, perineural cyst, neuromuscular disease, neuromyelitis optica, AL amyloidosis, AA amyloidosis, neuroleptic malignant syndrome, infectious disorder of the nervous system, central nervous system malformation, synaptopathy, nervous system neoplasm, sensory ganglionopathy, radiculitis, wet beriberi, perceptual disorders, prepubertal anorexia nervosa, neurocutaneous syndrome, neurovascular disorder, Wallerian degeneration, nervous system injury, neurosarcoidosis, neuroendocrine disorder, tubulinopathy, atactic disorder, hereditary neurological disease, meningitis-retention syndrome, KIF1A related neurological disorder, neurological pain disorder, neurodevelopmental disorder, post 5-alpha-reductase inhibitors treatment syndrome, post-selective serotonin reuptake inhibitor sexual dysfunction

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 18.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	10
PHASE2	5
PHASE4	2
PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT04814355	PHASE4	COMPLETED	The Effect of Celecoxib on Neuroinflammation in MDD
NCT07424001	PHASE4	COMPLETED	Preemptive IV Ibuprofen for Neurocognitive Recovery and Analgesic Needs After Inguinal Hernia Surgery
NCT05350774	PHASE2	ENROLLING_BY_INVITATION	Immunotherapy for Neurological Post-Acute Sequelae of SARS-CoV-2
NCT07269457	PHASE2	RECRUITING	Vitamin D3 for Moderate to Mild Traumatic Brain Injury: A Randomized Trial on Inflammation and Recovery (VIMOT)
NCT04318626	PHASE2	UNKNOWN	The Influence of [18F]PMPBB3 and [18F]THK5351 PET Distribution Patterns on Post-stroke Cognitive Impairment
NCT06322342	PHASE2	COMPLETED	Phase 2 Ascending Dose Safety and Efficacy Study of RVP-001, a Manganese-based MRI Contrast Agent
NCT07575516	PHASE2	COMPLETED	Effectiveness of Ashwagandha in Schizophrenia Patients on Risperidone
NCT03100136	PHASE1	COMPLETED	Test Re-Test Reliability of [11C]PF-06809247 as a Novel PET Tacer
NCT06432023	Not specified	RECRUITING	Imaging - Clinical Evaluation of Altered Nervous System Drainage
NCT06718452	Not specified	NOT_YET_RECRUITING	Tinnitus and Treatment With umPEA-LUT
NCT06725719	Not specified	RECRUITING	Translocator Protein PET/CT in Various TSPO-Related Disease
NCT06973837	Not specified	RECRUITING	Studying the Neurobiological Mechanisms of Non-specific Chronic Low Back Pain and Chronic Insomnia: a Four-group Cross-sectional Study
NCT07388160	Not specified	NOT_YET_RECRUITING	Neuroinflammatory Biomarkers After General Anesthesia: A Comparison Study
NCT03058328	Not specified	COMPLETED	The White Blood Cell Reactivity Following Surgical Trauma and Associated Regulatory Mechanisms.
NCT04423471	Not specified	WITHDRAWN	Neuroinflammation, Affective and Cognitive Symptoms in Major Depression and Psoriasis
NCT05129514	Not specified	TERMINATED	Imaging Lymphatic/Cerebrospinal Fluid (CSF) Drainage From the Head and Neck in Persons With Traumatic Brain Injury: Demonstration of Feasibility and Evaluation of Manual Therapy to Improve Drainage and Facilitate Cognitive Recovery
NCT06391866	Not specified	UNKNOWN	Neuroinflammation/Oxidative Stress/Cardiac Surgery
NCT06404203	Not specified	COMPLETED	The Effect of Oral Use of Lyophilised Royal Jelly on Cognitive Functions and Immune System in Elderly Individuals

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
CELECOXIB	4	1
RUTIN	3	1
WITHANOLIDE D	3	1
CHEMBL4762618	0	1