Neurovascular disorder

Summary

Neurovascular disorder (MONDO:0043218) is a disease (an umbrella term covering 29 Mondo subtypes) and 7 clinical trials. Top therapeutic interventions include tocilizumab. A subtype of nervous system disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Umbrella term: 29 Mondo subtypes
• Clinical trials: 7

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	neurovascular disorder
Mondo ID	MONDO:0043218
NCIT	C117007
UMLS	C3898144
MedGen	857738
Anatomy (UBERON)	UBERON:0002049
Is cancer (heuristic)	no

Also known as: disease of nervous system vasculature · nervous system disorder of vasculature · neurovascular disorder · vasculature nervous system disorder

Disease family

This is a subtype of nervous system disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › nervous system disorder › neurovascular disorder

Related subtypes (71): congenital nervous system disorder, central nervous system disorder, autoimmune disorder of the nervous system, cranial nerve neuropathy, peripheral nervous system disorder, neuronitis, diplegia of upper limb, retinal disorder, developmental disability, restless legs syndrome, movement disorder, toxic encephalopathy, Barre-Lieou syndrome, Gerstmann syndrome, drug-induced akathisia, drug-induced dyskinesia, stiff-person syndrome, Worster-Drought syndrome, corneal-cerebellar syndrome, pachygyria-intellectual disability-epilepsy syndrome, porencephaly-cerebellar hypoplasia-internal malformations syndrome, symmetrical thalamic calcifications, neonatal brainstem dysfunction, primary orthostatic hypotension, rippling muscle disease with myasthenia gravis, periodic paralysis, qualitative or quantitative protein defects in neuromuscular diseases, specific learning disability, cerebellar hypoplasia-tapetoretinal degeneration syndrome, locked-in syndrome, dopa-responsive dystonia, idiopathic recurrent stupor, chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids, spontaneous periodic hypothermia, Sydenham chorea, duplication of the pituitary gland, Balint syndrome, paraneoplastic neurologic syndrome, persistent idiopathic facial pain, serotonin syndrome, hypothalamic adipsic hypernatraemia syndrome, exercise-induced malignant hyperthermia, perineural cyst, neuromuscular disease, neuromyelitis optica, AL amyloidosis, AA amyloidosis, neuroleptic malignant syndrome, infectious disorder of the nervous system, central nervous system malformation, synaptopathy, nervous system neoplasm, sensory ganglionopathy, radiculitis, wet beriberi, perceptual disorders, prepubertal anorexia nervosa, neurocutaneous syndrome, Wallerian degeneration, nervous system injury, neurosarcoidosis, neuroendocrine disorder, tubulinopathy, atactic disorder, hereditary neurological disease, meningitis-retention syndrome, KIF1A related neurological disorder, neurological pain disorder, neurodevelopmental disorder, post 5-alpha-reductase inhibitors treatment syndrome, post-selective serotonin reuptake inhibitor sexual dysfunction

Subtypes (29): retinal ischemia, retinal dystrophies primarily involving Bruch’s membrane, retinal vascular disorder, choroid plexus cancer, cavernous sinus meningioma, central nervous system angiosarcoma, central nervous system hemangioma, central nervous system vasculitis, choroidal sclerosis, migraine disorder, malignant jugulotympanic paraganglioma, choroid cancer, intracranial hypertension, microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability, lymphatic malformation 5, Norman-Roberts syndrome, ornithine aminotransferase deficiency, choroideremia, cerebrovascular disorder, choroidal dystrophy, central areolar 2, trigeminal autonomic cephalalgia, hemangioblastoma, Wyburn-Mason syndrome, neoplasm of aortic body, benign neoplasm of choroid, hemangioma of retina, eyelid capillary hemangioma, choroidal dystrophy, central areolar, 1, benign choroid plexus neoplasm

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 7.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	6
PHASE3	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT04888221	PHASE3	ACTIVE_NOT_RECRUITING	Efficacy of Tocilizumab in Association to Steroids in Giant Cell Arteritis With Cerebro-vascular Involvement
NCT06752096	Not specified	RECRUITING	Robot-Assisted Neurovascular Intervention
NCT03917368	Not specified	UNKNOWN	Ultrasound Evaluation of the Jugular Venous Pulse (US-JVP)
NCT04537611	Not specified	UNKNOWN	Deoxyhemoglobin Concentration Changes and Cerebral Perfusion Imaging
NCT04568161	Not specified	COMPLETED	Effect of Anthracyclines and Cyclophosphamide on Cardiovascular Responses
NCT04865718	Not specified	UNKNOWN	Intraoperative Laser Speckle Contrast Imaging of Cerebral Blood Flow
NCT06189378	Not specified	COMPLETED	Adherence to Blood Pressure Diaries With Personalized Visuals

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
TOCILIZUMAB	4	1