Neutrophil actin dysfunction

Summary

Neutrophil actin dysfunction (MONDO:0009755) is a disease and 13 clinical trials. Top therapeutic interventions include nicotinamide riboside and nadide. A subtype of melanocytic nevus — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 13

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	neutrophil actin dysfunction
Mondo ID	MONDO:0009755
MeSH	C564942
OMIM	257150
Orphanet	625
NCIT	C3694
UMLS	C1850380
MedGen	338036
GARD	0027357
Is cancer (heuristic)	no

Also known as: Atypical Nevus · Clark Nevus · Clark’s Nevus · dysplastic nevi · dysplastic Nevus · dysplastic nevus · lentiginous Nevus · NAD · neutrophil actin dysfunction · Nevus with architectural disorder · Nevus with architectural disorder and cytologic atypia of melanocytes

Disease family

This is a subtype of melanocytic nevus. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › integumentary system disorder › integumentary system benign neoplasm › benign neoplasm of skin › melanocytic nevus › neutrophil actin dysfunction

Related subtypes (27): conjunctival nevus, blue nevus, halo nevus, intradermal nevus, pigmented spindle cell nevus, nevus, epidermal, neurocutaneous melanocytosis, CHILD syndrome, Becker nevus syndrome, CLOVES syndrome, nevus comedonicus syndrome, segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome, congenital panfollicular nevus, porokeratotic eccrine ostial and dermal duct nevus, hereditary mucosal leukokeratosis, linear verrucous nevus syndrome, nevus of Ota, nevus of Ito, phakomatosis pigmentokeratotica, PENS syndrome, Angora hair nevus, didymosis aplasticosebacea, scalp syndrome, Nevada syndrome, palpebral nevus, large congenital melanocytic nevus, benign melanocytic skin nevus

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 13.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	12
PHASE2	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00586040	PHASE2	COMPLETED	Photochemical Tissue Bonding
NCT05446155	Not specified	RECRUITING	BioMEL- Diagnostic and Prognostic Factors in Melanoma.
NCT06005350	Not specified	ACTIVE_NOT_RECRUITING	Nicotinamide Riboside Impact on Extracellular Nicotinamide Adenine Dinucleotide (NAD+)
NCT07132801	Not specified	NOT_YET_RECRUITING	Comparison of Two Qualia NAD⁺ Formulations on Intracellular NAD⁺ Levels
NCT07203131	Not specified	RECRUITING	Evaluation of the Impact of an Alteration of NAD+ Metabolism on the Renal Prognosis of Patients Admitted to Intensive Care (NI-AKI)
NCT07328100	Not specified	NOT_YET_RECRUITING	Efficacy and Safety of Coenzyme I for Injection on Vascular Aging.
NCT00339222	Not specified	COMPLETED	Family Study of Melanoma in Italy
NCT00710489	Not specified	COMPLETED	Potential Research Study Participant Registry
NCT02942888	Not specified	COMPLETED	The Effects of Nicotinamide Adenine Dinucleotide (NAD) on Brain Function and Cognition
NCT03094273	Not specified	COMPLETED	Prospective Study of 2 mm Margins for the Biopsy of Dysplastic Nevi
NCT03362138	Not specified	UNKNOWN	Artificial Intelligence-assisted Evaluation of Pigmented Skin Lesions
NCT03725449	Not specified	COMPLETED	Internet-based Intervention for Skin Self-Examination in Participants With Increased Risk for Melanoma
NCT05561712	Not specified	COMPLETED	Method Optimization for the Quantification of the NAD

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
NICOTINAMIDE RIBOSIDE	3	1
NADIDE	2	1