Nocturnal enuresis
disease diseaseOn this page
Also known as bedwettingenuresis, nocturnalsleep enuresis
Summary
Nocturnal enuresis (MONDO:0000022) is a disease and 64 clinical trials. Top therapeutic interventions include desmopressin, fluoxetine, and oxybutynin. A subtype of enuresis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 64
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | nocturnal enuresis |
| Mondo ID | MONDO:0000022 |
| MeSH | D053206 |
| ICD-11 | 1048673005 |
| NCIT | C118172 |
| UMLS | C0270327 |
| MedGen | 124355 |
| Is cancer (heuristic) | no |
Also known as: bedwetting · enuresis, nocturnal · sleep enuresis
Disease family
This is a subtype of enuresis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by developmental or physiological process › psychiatric disorder › enuresis › nocturnal enuresis
Subtypes (2): enuresis, nocturnal, 1, nocturnal enuresis, 2
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 64.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 51 |
| PHASE4 | 7 |
| PHASE3 | 4 |
| PHASE2 | 1 |
| EARLY_PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT00209261 | PHASE4 | COMPLETED | A 6-week Open Label Cross-over Study With 2 Different Daily Doses of Minirin® Oral Lyophilisate in Children and Adolescents With Primary Nocturnal Enuresis (PNE) |
| NCT00245479 | PHASE4 | COMPLETED | A Study of Oral Desmopressin in Previously Untreated Children Aged 5 to 15 Years With Primary Nocturnal Enuresis |
| NCT01582542 | PHASE4 | UNKNOWN | Desmopressin for Improving Nocturnal Enuresis in Patients After Radical Cystectomy With Bladder Reconstruction |
| NCT02337413 | PHASE4 | WITHDRAWN | Urotherapy vs. Urotherapy With Constipation Treatment for Nocturnal Enuresis |
| NCT03389412 | PHASE4 | COMPLETED | The Effect of Selecting Treatment With Desmopressin or Alarm to Children With Enuresis Based on Home Recordings. |
| NCT03510975 | PHASE4 | COMPLETED | A New Check-list Method for Nocturnal Enuresis |
| NCT04420585 | PHASE4 | TERMINATED | Desmopressin for Bedwetting in Children With SCD |
| NCT00230594 | PHASE3 | COMPLETED | Desmopressin Response in the Young |
| NCT01078753 | PHASE3 | COMPLETED | Study With Two Different Doses of Desmopressin Orally Lyophilisate Tablet With Nocturnal Enuresis |
| NCT02538302 | PHASE3 | COMPLETED | Minirin Versus Oxybutynin for Nocturnal Enuresis in Children |
| NCT04676139 | PHASE3 | UNKNOWN | The Safety and Efficacy of Fluoxetine for Refractory Primary Mono-symptomatic Nocturnal Enuresis in Children |
| NCT01575678 | PHASE2 | UNKNOWN | The Effect of Melatonin on Nocturnal Enuresis |
| NCT06841666 | EARLY_PHASE1 | NOT_YET_RECRUITING | Evaluating the Efficacy of Atomoxetine in Reducing Primary Nocturnal Enuresis in Children With ADHD: A Randomized, Placebo-Controlled Study |
| NCT06135311 | Not specified | RECRUITING | Optimal Pulse Width Used in Transcutaneous Electrical Nerve Stimulation for Treating Nocturnal Enuresis in Children |
| NCT06586476 | Not specified | NOT_YET_RECRUITING | The Role of Timed Awakening in Treatment of Enuresis |
| NCT06853379 | Not specified | NOT_YET_RECRUITING | Aromatherapy Versus Diet |
| NCT06883851 | Not specified | RECRUITING | Effectiveness of Pelvic Floor Muscle Rehabilitation Combined With Desmopressin in Children With Primary Monosymptomatic Nocturnal Enuresis |
| NCT07000656 | Not specified | RECRUITING | Micturition Desire-Relaxation Training Device for Lower Urinary Tract Dysfunction in Children |
| NCT07003126 | Not specified | NOT_YET_RECRUITING | A Cohort Study on Treating Primary Nocturnal Enuresis by Regulating Central-Peripheral Circadian Rhythm |
| NCT07028645 | Not specified | ACTIVE_NOT_RECRUITING | Uroflowmetry and Nocturnal Enuresis |
| NCT07339865 | Not specified | ENROLLING_BY_INVITATION | Study of Transition in Real-life Experiences Affecting Micturition and Well-being in Adolescent Years |
| NCT07508111 | Not specified | NOT_YET_RECRUITING | Causes and Types of Nocturnal Enuresis in Children |
| NCT01368913 | Not specified | COMPLETED | MINRIN® Orally Disintegrating Tablet (Fast Dissolving Desmopressin) and Tablets in Treatment of Primary Nocturnal Enuresis |
| NCT02068560 | Not specified | COMPLETED | The Effect of Gender on Antidiuresis - Evaluated by Graded Low Dose Desmopressin Infusion |
| NCT02178826 | Not specified | COMPLETED | Nocturnal Enuresis and Rapid Maxillary Expansion |
| NCT02315560 | Not specified | COMPLETED | Foot Neuromodulation for Nocturnal Enuresis |
| NCT02328092 | Not specified | COMPLETED | A Double-blind Randomized Clinical Trial on the Efficacy of Magnetic Sacral Roots Stimulation for the Treatment of NE |
| NCT02600676 | Not specified | COMPLETED | Transcutaneous Electric Nerve Stimulation (TENS) in Children With Enuresis |
| NCT02621736 | Not specified | COMPLETED | Copeptin for Prediction of Treatment Response in Children With Monosymptomatic Nocturnal Enuresis (MEN). |
| NCT02636387 | Not specified | TERMINATED | Desmopressin as a Therapy for Bedwetting in Children With Sickle Cell Disease |
| NCT02747810 | Not specified | WITHDRAWN | Pilot Study: Foot Neuromodulation for Nocturnal Enuresis in Children |
| NCT02747849 | Not specified | COMPLETED | Hand & Foot Nocturnal Enuresis TENS Study |
| NCT02900495 | Not specified | COMPLETED | Transcutaneous Electric Nerve Stimulation (TENS) for the Treatment of Nocturnal Enuresis in Children |
| NCT03047720 | Not specified | COMPLETED | Scheduled Awakenings for the Treatment of Nocturnal Enuresis |
| NCT03199508 | Not specified | UNKNOWN | Clinical Values of Voiding Diary for Diagnosis and Treatment for Monosymptomatic Enuresis in Children |
| NCT03477812 | Not specified | UNKNOWN | Sleep and Nocturnal Enuresis: Ambulatory Polysomnographic Study |
| NCT03522818 | Not specified | UNKNOWN | Enuresis Alarm - Is a Manual Trigger System Beneficial? |
| NCT03543995 | Not specified | COMPLETED | The Relationship Between Nocturnal Enuresis And Spina Bifida Occulta |
| NCT03812094 | Not specified | COMPLETED | Basic Bladder Advice and Alarm Therapy in Nocturnal Enuresis |
| NCT03883724 | Not specified | COMPLETED | Impact of Behavioral Treatment of Insomnia on Nighttime Urine Production |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| DESMOPRESSIN | 4 | 25 |
| FLUOXETINE | 4 | 4 |
| OXYBUTYNIN | 4 | 3 |
| POLYETHYLENE GLYCOL 3350 | 4 | 1 |
| PROPIVERINE | 4 | 1 |
| VALPROIC ACID | 4 | 1 |
| LACTOSE, ANHYDROUS | 3 | 1 |