Nodular basal cell carcinoma

Summary

Nodular basal cell carcinoma (MONDO:0002937) is a cancer and 10 clinical trials. Top therapeutic interventions include imiquimod and stem bromelain. A subtype of skin basal cell carcinoma — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer
• Clinical trials: 10

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	nodular basal cell carcinoma
Mondo ID	MONDO:0002937
DOID	DOID:4280
NCIT	C5568
SNOMED CT	403910009
UMLS	C4083056
MedGen	908229
Is cancer (heuristic)	yes

Also known as: basal cell carcinoma, nodular (morphologic abnormality) · Nodulo-ulcerative basal cell carcinoma · Rodent Ulcer · skin nodulo-ulcerative basal cell carcinoma

Disease family

This is a subtype of skin basal cell carcinoma. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › integumentary system disorder › integumentary system cancer › skin cancer › skin carcinoma › skin basal cell carcinoma › nodular basal cell carcinoma

Related subtypes (24): penis basal cell carcinoma, scrotum basal cell carcinoma, metatypical basal cell carcinoma, skin pigmented basal cell carcinoma, anal margin basal cell carcinoma, sebaceous basal cell carcinoma, external ear basal cell carcinoma, micronodular basal cell carcinoma, adamantinoid basal cell epithelioma, skin fibroepithelial basal cell carcinoma, morpheaform basal cell carcinoma, skin clear cell basal cell carcinoma, skin adenoid basal cell carcinoma, follicular basal cell carcinoma, skin infiltrative basal cell carcinoma, superficial multifocal basal cell carcinoma, vulva basal cell carcinoma, skin cystic basal cell carcinoma, sarcomatoid basal cell carcinoma, signet ring basal cell carcinoma, basosquamous carcinoma, salivary gland basal cell adenocarcinoma, infundibulocystic basal cell carcinoma, follicular atrophoderma-basal cell carcinoma

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 10.

Phase distribution (across all retrieved trials)

Phase	Trials
PHASE1/PHASE2	3
Not specified	3
PHASE2	2
PHASE3	1
PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT02242929	PHASE3	UNKNOWN	Surgery Versus Combined Treatment With Curettage and Imiquimod for Nodular Basal Cell Carcinoma
NCT05157763	PHASE1/PHASE2	RECRUITING	A Study to Evaluate the Safety and Efficacy of EscharEx (EX-02) in the Treatment of Basal Cell Carcinoma
NCT01808950	PHASE1/PHASE2	TERMINATED	Efficacy and Safety Trial of Topical Resiquimod Gel (0.06%) in Patients With Nodular Basal Cell Carcinoma
NCT04470726	PHASE1/PHASE2	COMPLETED	Safety and Efficacy Evaluation of AIV001 in Nonmelanoma Skin Cancer of the Low Risk Basal Cell Carcinoma Subtype
NCT04552990	PHASE2	COMPLETED	Use of Jet-injection in Photodynamic Therapy for Basal Cell Carcinoma
NCT06608238	PHASE2	COMPLETED	Phase 2 Study Evaluating the Safety and Efficacy of Microneedle-mediated Delivery of Doxorubicin (D-MNA) in Patients With Nodular Basal Cell Carcinoma.
NCT02018679	PHASE1	COMPLETED	Er:YAG Ablative Fractional Laser Assisted-Photodynamic Therapy Versus Photodynamic Therapy for Basal Cell Carcinoma
NCT04744935	Not specified	ACTIVE_NOT_RECRUITING	Optical Coherence Tomography Guided Laser Treatment of Basal Cell Carcinoma
NCT07384078	Not specified	NOT_YET_RECRUITING	High Intensity Focused Ultrasound vs. Cryotherapy in the Treatment of Basal Cell Carcinomas and Bowen’s Disease in Adults
NCT02270645	Not specified	COMPLETED	Randomized Pilot Study of Treatment for BCC Using the Multiplex 595/1064 nm Laser

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
IMIQUIMOD	4	1
STEM BROMELAIN	4	1