Nodular non-suppurative panniculitis

Summary

Nodular non-suppurative panniculitis (MONDO:0018063) is a disease. A subtype of panniculitis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: Unknown (Worldwide)
• Phenotypes (HPO): 15

Clinical features

Signs & symptoms

Clinical features (HPO)

15 HPO clinical features (Orphanet curated; top 15 by frequency):

HPO ID	Term	Frequency
HP:0000969	Edema	Very frequent (80-99%)
HP:0001482	Subcutaneous nodule	Very frequent (80-99%)
HP:0001824	Weight loss	Very frequent (80-99%)
HP:0001945	Fever	Very frequent (80-99%)
HP:0002017	Nausea and vomiting	Very frequent (80-99%)
HP:0002027	Abdominal pain	Very frequent (80-99%)
HP:0002829	Arthralgia	Very frequent (80-99%)
HP:0003326	Myalgia	Very frequent (80-99%)
HP:0008065	Aplasia/Hypoplasia of the skin	Very frequent (80-99%)
HP:0010783	Erythema	Very frequent (80-99%)
HP:0012490	Panniculitis	Very frequent (80-99%)
HP:0001744	Splenomegaly	Occasional (5-29%)
HP:0002240	Hepatomegaly	Occasional (5-29%)
HP:0002960	Autoimmunity	Occasional (5-29%)
HP:0100533	Inflammatory abnormality of the eye	Occasional (5-29%)

Identifiers

Disease identifiers

Field	Value
Canonical name	nodular non-suppurative panniculitis
Mondo ID	MONDO:0018063
EFO	EFO:1000742
MeSH	D010201
Orphanet	33577
DOID	DOID:1525
SNOMED CT	33760009
UMLS	C0030328
MedGen	10559
GARD	0007879
MedDRA	10047883
Is cancer (heuristic)	no

Also known as: idiopathic lobular panniculitis · idiopathic nodular panniculitis · nodular nonsuppurative panniculitis · panniculitis nodular nonsuppurative · Pfeiffer-Weber-Christian syndrome · Relapsing febrile nodular nonsuppurative panniculitis · Relapsing febrile nodular panniculitis · WCD · Weber Christian disease · Weber-Christian disease · Weber-Christian panniculitis

Disease family

This is a subtype of panniculitis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › integumentary system disorder › panniculitis › nodular non-suppurative panniculitis

Related subtypes (5): panniculitis and localized lipodystrophy, lupus erythematosus panniculitis, cytophagic histiocytic panniculitis, lipodermatosclerosis, erythema nodosum

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.