Non-infectious anterior uveitis

Summary

Non-infectious anterior uveitis (MONDO:0017634) is a disease and 8 clinical trials. Top therapeutic interventions include prednisolone, dazdotuftide, and reproxalap. A subtype of anterior uveitis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 8

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	non-infectious anterior uveitis
Mondo ID	MONDO:0017634
Orphanet	306648
SNOMED CT	267619000
UMLS	C0339317
MedGen	573080
GARD	0021260
Is cancer (heuristic)	no

Also known as: non-infectious iridocyclitis

Disease family

This is a subtype of anterior uveitis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › disorder of orbital region › eye disorder › uveal disorder › uveitis › anterior uveitis › non-infectious anterior uveitis

Related subtypes (2): iridocyclitis, idiopathic anterior uveitis

Subtypes (3): phacoanaphylactic uveitis, Fuchs heterochromic iridocyclitis, sympathetic ophthalmia

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 8.

Phase distribution (across all retrieved trials)

Phase	Trials
PHASE3	3
PHASE1/PHASE2	2
PHASE2	2
PHASE4	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT04426734	PHASE4	UNKNOWN	Evaluation of DEXTENZA in the Management of Pain and Inflammation in Patients With Anterior Uveitis Compared to Standard of Care Topical Corticosteroids
NCT07136805	PHASE3	NOT_YET_RECRUITING	A Phase 3 Study of VVN461 Ophthalmic Solution for Noninfectious Anterior Uveitis
NCT03131154	PHASE3	COMPLETED	SOLACE Trial - A Phase 3 Trial in Subjects With Non-infectious Anterior-uveitis.
NCT05042609	PHASE3	COMPLETED	A Study of TRS01 in Subjects With Active Non-infectious Anterior Uveitis Including Subjects With Uveitic Glaucoma
NCT07285070	PHASE2	RECRUITING	Tacrolimus Ophthalmic Solution for the Treatment of Non-infectious Anterior Uveitis
NCT02309385	PHASE1/PHASE2	COMPLETED	Safety and Efficacy Study of DSP-Visulex for the Treatment of Anterior Uveitis
NCT02406209	PHASE2	COMPLETED	A Safety and Efficacy Study of NS2 in Patients With Anterior Uveitis
NCT04222712	PHASE1/PHASE2	COMPLETED	A Study to Evaluate TRS01 Eye Drops in Participants With Active Non-infectious Anterior Uveitis

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
PREDNISOLONE	4	3
DAZDOTUFTIDE	3	1
REPROXALAP	3	1