Non-syndromic unicoronal and sagittal craniosynostosis

Summary

Non-syndromic unicoronal and sagittal craniosynostosis (MONDO:0850080) is a disease. A subtype of craniosynostosis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: <1 / 1 000 000 (Worldwide) [Orphanet-validated]

Clinical features

Epidemiology

Prevalence records

1 prevalence record(s), Orphanet:

Type	Class	Value	Geography	Validation
Point prevalence	<1 / 1 000 000		Worldwide	Validated

Identifiers

Disease identifiers

Field	Value
Canonical name	non-syndromic unicoronal and sagittal craniosynostosis
Mondo ID	MONDO:0850080
Orphanet	620186
UMLS	C5680396
MedGen	1842804
GARD	0022477
Is cancer (heuristic)	no

Disease family

This is a subtype of craniosynostosis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › skeletal system disorder › bone disorder › bone development disease › dysostosis › synostosis › craniosynostosis › non-syndromic unicoronal and sagittal craniosynostosis

Related subtypes (28): craniosynostosis, Adelaide type, craniosynostosis with ectopia lentis, craniosynostosis syndrome, autosomal recessive, craniosynostosis with ocular abnormalities and hallucal defects, isolated craniosynostosis, syndromic craniosynostosis, craniosynostosis Fontaine type, craniosynostosis Maroteaux Fonfria type, craniosynostosis alopecia brain defect, craniosynostosis arthrogryposis cleft palate, craniosynostosis autosomal dominant, craniosynostosis cleft lip palate arthrogryposis, craniosynostosis contractures cleft, craniosynostosis exostoses nevus epibulbar dermoid, craniosynostosis intellectual disability heart defects, Hordnes Engebretsen Knudtson syndrome, Iida Kannari syndrome, mehta lewis patton syndrome, non-syndromic unicoronal craniosynostosis, non-syndromic unilambdoid craniosynostosis, non-syndromic unifrontosphenoidal craniosynostosis, non-syndromic unisquamosal craniosynostosis, non-syndromic multisutural craniosynostosis, non-syndromic non-specific multisutural craniosynostosis, non-syndromic bilambdoid craniosynostosis, non-syndromic metopic and sagittal craniosynostosis, non-syndromic bicoronal and metopic craniosynostosis, non-syndromic bicoronal and sagittal craniosynostosis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.