Nosocomial infection

Summary

Nosocomial infection (MONDO:0043544) is a disease and 181 clinical trials. Top therapeutic interventions include methylene blue cation, chlorhexidine, and clavulanic acid. A subtype of infectious disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 181

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	nosocomial infection
Mondo ID	MONDO:0043544
MeSH	D003428
NCIT	C115164
SNOMED CT	19168005
UMLS	C0205721
MedGen	61441
Is cancer (heuristic)	no

Also known as: associated infection, Healthcare · associated infections, Healthcare · Cross infections · HAI · health care associated infection · health care associated infections · Healthcare associated infection · Healthcare associated infections · Healthcare-associated infection · hospital infection · hospital infections · hospital-acquired infection · hospital-onset infection · infection, Cross · infection, Healthcare associated · infection, hospital · infection, nosocomial · infections, Cross · infections, Healthcare associated · infections, hospital (+4 more)

Disease family

This is a subtype of infectious disease. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › infectious disease › nosocomial infection

Related subtypes (34): infective endocarditis, hirudiniasis, fungal infectious disease, infectious peritonitis, epididymitis, viral infectious disease, bacterial infectious disease, parasitic infectious disease, abscess, Ciliophora infectious disease, hookworm infectious disease, infectious embryofetopathy, mycetoma, infectious disorder of the nervous system, ear infection, sexually transmitted disease, puerperal infection, Acanthamoeba infectious disease, infectious myositis, infective vaginitis, skin disorder caused by infection, respiratory tract infectious disorder, nail infection, infective arthritis, digestive system infectious disorder, eye infectious disorder, prosthesis-related infectious disease, vector-borne disease, coinfection, urinary tract infection, hemorrhagic fever, protothecosis, pythiosis, infectious disease with sepsis

Subtypes (3): iatrogenic Kaposi’s sarcoma, iatrogenic botulism, iatrogenic Creutzfeldt-Jakob disease

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

0 approved, 2 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.

Drug	Development status
Daptomycin	Phase 3 (in late-stage trials)
Vancomycin	Phase 3 (in late-stage trials)

Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Glutamine, Maltodextrin.

Clinical trials & evidence

Clinical trials

Clinical trials: 181.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	143
PHASE4	11
PHASE3	11
PHASE2	9
PHASE2/PHASE3	3
PHASE1/PHASE2	2
PHASE1	2

Top trials by phase / activity

NCT	Phase	Status	Title
NCT05979545	PHASE4	RECRUITING	EaRly impAct theraPy With Ceftazidime-avibactam Via rapID Diagnostics
NCT02032394	PHASE4	UNKNOWN	Effect of Chlorhexidine on Bacteriuria
NCT02033187	PHASE4	COMPLETED	Daily Chlorhexidine Bathing and Infection Rates in Critically-ill Patients
NCT02328183	PHASE4	UNKNOWN	Efficacy of Polymyxin B Against Infections Caused by Extensively Drug-resistant (XDR) Gram-Negative Bacteria
NCT03365635	PHASE4	COMPLETED	Administration of Zepatier (Grazoprevir Plus Elbasvir) in Chronic Hemodialysis (HD) Patients With Hepatitis C
NCT03639363	PHASE4	COMPLETED	4% Chlorhexidine Gluconate Daily Bathing for Prevention of Hospital-acquired Infections in Intensive Care Settings
NCT04072211	PHASE4	COMPLETED	Demonstration Project on Health Care Worker Protection Against Hepatitis B in Kalulushi District
NCT04192435	PHASE4	COMPLETED	Tranexamic Acid to Reduce Infection After Gastrointestinal Surgery
NCT04748588	PHASE4	TERMINATED	Treatment of Nosocomial COVID-19
NCT04995133	PHASE4	UNKNOWN	Colistin Intravenous Administration in Critically Ill Patients Suffering From Hospital Infections Caused by Multi-antibiotic-resistant Germs.
NCT05575427	PHASE4	UNKNOWN	Efficacy of Combination Therapy With Minocycline for Treatment of Stenotrophomonas Maltophilia Infections
NCT06833125	PHASE3	ENROLLING_BY_INVITATION	The Prophylactic Effect of Garlic Tablets to Prevent Nosocomial Infections in Intensive Care Unit Patients.
NCT00150332	PHASE3	COMPLETED	Linezolid for the Treatment of Infections Caused by Methicillin Resistant Staphylococcus Aureus in Japan
NCT00272675	PHASE2/PHASE3	COMPLETED	Prevention of Nosocomial Infection by Decontamination of the Naso- and Oropharynx With Chlorhexidine (NONI Trial)
NCT00549393	PHASE2/PHASE3	COMPLETED	Study of Bathing With Chlorhexidine Impregnated Cloths on Nosocomial Infections in the Pediatric Intensive Care Unit
NCT00727363	PHASE3	TERMINATED	Prophylactic Probiotics in Premature Infants
NCT00787345	PHASE3	COMPLETED	Simulation-based Training for Surgery Residents in Aseptic Techniques
NCT01046656	PHASE3	COMPLETED	L Reuteri for the Prevention of Nosocomial Diarrhea
NCT01110421	PHASE3	TERMINATED	A Safety and Tolerability Study of Doripenem Compared With Cefepime in Hospitalized Children With Bacterial Pneumonia
NCT01340469	PHASE3	COMPLETED	Effect of Oral Probiotic Supplementation on The Rate of Hospital Acquired Infection and Necrotizing Enterocolitis in Preterm Very Low Birth Weight Infants
NCT01515020	PHASE3	TERMINATED	Daptomycin Versus Vancomycin in the Treatment of Nosocomial or Healthcare-associated MRSA Bacteremia
NCT02558192	PHASE3	COMPLETED	Administration of a Lactobacillus GG and Vitamins Containing Mixture is Effective in Preventing Nosocomial Infection in Children
NCT03500874	PHASE3	TERMINATED	Adjuvant Systemic Chemotherapy With or Without HAI-FUDR in Patients With Resected CRLM
NCT03795090	PHASE2/PHASE3	COMPLETED	A Multi-level Antimicrobial Surface Coating for a Healthier Environment
NCT05485051	PHASE3	COMPLETED	Daily Chlorexidine Bath for Health Care Associated Infection Prevention
NCT00438269	PHASE2	COMPLETED	Pilot Study of the Utility of Empiric Antibiotic Therapy for Suspected ICU-Acquired Infection
NCT00502801	PHASE2	COMPLETED	An Effectiveness, Safety, and Microbiology Study of Doripenem in Patients With Nosocomial (Hospital-acquired) Pneumonia
NCT00854633	PHASE1/PHASE2	UNKNOWN	Study of Talactoferrin Oral Solution for Nosocomial Infection in Preterm Infants
NCT00893763	PHASE2	COMPLETED	Strategies To Prevent Pneumonia 2 (SToPP2)
NCT03189043	PHASE2	UNKNOWN	Controlled Crossover Study of AIONX Antimicrobial Surface for the Prevention of Healthcare-associated Infections
NCT03423147	PHASE2	TERMINATED	Preoperative Application of Chlorhexidine to Reduce Infection With Cesarean Section After Labor
NCT03865706	PHASE2	COMPLETED	Inulin for Infections in the Intensive Care Unit
NCT04312243	PHASE2	TERMINATED	NO Prevention of COVID-19 for Healthcare Providers
NCT04532060	PHASE2	COMPLETED	Clinical Trial Evaluating Chlorine e6 Derivative-mediated Antimicrobial Photodynamic Therapy as a Treatment for Denture Stomatitis
NCT05090657	PHASE2	COMPLETED	Nasal Photodisinfection in All Patients Presenting for Surgery for a Wide Range of Surgical Procedures
NCT05797818	PHASE1/PHASE2	COMPLETED	Red Light Photobiomodulation and Topical Disinfectants
NCT00130221	PHASE1	COMPLETED	Skin Cleansing With Chlorhexidine to Decrease Hospital Acquired Infections
NCT02870062	PHASE1	UNKNOWN	Impact of Daily Bathing With Chlorhexidine in the Critical Patient
NCT03465683	Not specified	RECRUITING	Transmission of ESBL-producing Enterobacteriaceae
NCT05153694	Not specified	RECRUITING	Infectious Complications After Cystectomy: A Prospective Observational Study

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
METHYLENE BLUE CATION	4	6
CHLORHEXIDINE	4	4
CLAVULANIC ACID	4	3
DORIPENEM	4	2
IRINOTECAN	4	2
CEFEPIME	4	1
COLISTIMETHATE SODIUM	4	1
COLISTIN	4	1
DAPTOMYCIN	4	1
FLOXURIDINE	4	1
INULIN	4	1
LACTULOSE	4	1
LINEZOLID	4	1
MINOCYCLINE	4	1
NYSTATIN	4	1
PIPERACILLIN	4	1
POLYMYXIN B	4	1
POVIDONE-IODINE	4	1
SODIUM CHLORIDE	4	1
TAZOBACTAM	4	1
TRANEXAMIC ACID	4	1
LACTOFERRIN, BOVINE	3	1
TALACTOFERRIN ALFA	3	1
CHEMBL2397513	0	1
CHEMBL373756	0	1
CHEMBL3989738	0	1
CHEMBL4636958	0	1
CHEMBL5281080	0	1
CHEMBL2221249	0	1
CHEMBL4793072	0	1