Nuclear cataract

Summary

Nuclear cataract (MONDO:0045050) is a disease and 7 clinical trials. A subtype of cataract — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 7

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	nuclear cataract
Mondo ID	MONDO:0045050
ICD-11	2020818341
NCIT	C135176
SNOMED CT	53889007
UMLS	C0392557
MedGen	140274
Anatomy (UBERON)	UBERON:0000390
Is cancer (heuristic)	no

Also known as: cataract (disease) of lens nucleus · lens nucleus cataract (disease)

Data availability: 1 HPO phenotype.

Disease family

This is a subtype of cataract. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › disorder of orbital region › eye disorder › lens disorder › cataract › nuclear cataract

Related subtypes (28): immature cataract, diabetic cataract, mature cataract, tetanic cataract, myotonic cataract, senile cataract, diabetes mellitus type 2 associated cataract, cataract 4 multiple types, cataract 29, cataract 1 multiple types, early-onset non-syndromic cataract, cataract 3 multiple types, cataract 9 multiple types, cataract 28, cataract 18, cataract 12 multiple types, cataract 34 multiple types, cataract 36, bhaskar jagannathan syndrome, autosomal dominant cataract, craniostenosis cataract, Kozlowski Rafinski Klicharska syndrome, cataract 49, cataract 48, hypermature cataract, cortical cataract, cataract 2, multiple types, cataract 50 with or without glaucoma

Subtypes (1): nuclear senile cataract

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 7.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	6
PHASE2	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00825721	PHASE2	UNKNOWN	Dose-Ranging Study of an Ophthalamic Solution in Patients With Loss of Visual Function Due to Age-Related Nuclear Cataract
NCT07019896	Not specified	RECRUITING	Minimal Vitrectomy Surgery for Epiretinal Membrane
NCT07223866	Not specified	NOT_YET_RECRUITING	The Impact of Physiologic Cataract Surgery on Patient Comfort and Medication Usage
NCT04975971	Not specified	COMPLETED	A Retrospective Review of DEXTENZA 0.4 mg inseRt Following Corneal Transplant or Cataract Surgery
NCT05736042	Not specified	UNKNOWN	Microinterventional Endocapsular Nuclear Fragmentation Assisted Cataract Surgery
NCT05765201	Not specified	COMPLETED	Phacoemulsification at High IOP and Physiologic IOP: Impact on Anterior and Posterior Segment Physiology
NCT06325397	Not specified	COMPLETED	Less Discomfort and Less Pharmacology. Cataract Surgery at Physiologic Intraocular Pressure (IOP)