Obstructive jaundice
diseaseOn this page
Also known as obstructive hyperbilirubinemia
Summary
Obstructive jaundice (MONDO:0006874) is a disease and 32 clinical trials. Top therapeutic interventions include methylene blue cation, ursodiol, and porfimer sodium. A subtype of cholestasis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 32
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | obstructive jaundice |
| Mondo ID | MONDO:0006874 |
| EFO | EFO:1001068 |
| MeSH | D041781 |
| DOID | DOID:13603 |
| SNOMED CT | 44018007 |
| UMLS | C0022354 |
| MedGen | 43988 |
| MedDRA | 10029982 |
| Is cancer (heuristic) | no |
Also known as: obstructive hyperbilirubinemia
Disease family
This is a subtype of cholestasis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › digestive system disorder › hepatobiliary disorder › biliary tract disorder › bile duct disorder › cholestasis › obstructive jaundice
Related subtypes (4): extrahepatic cholestasis, biliary atresia, intrahepatic cholestasis, parenteral nutrition-associated cholestasis
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
Drugs indicated for this disease
0 approved, 4 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.
| Drug | Development status |
|---|---|
| Inosine | Phase 3 (in late-stage trials) |
| Methionine | Phase 3 (in late-stage trials) |
| Niacinamide | Phase 3 (in late-stage trials) |
| Sodium Chloride | Phase 3 (in late-stage trials) |
Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Ursodiol.
Clinical trials & evidence
Clinical trials
Clinical trials: 32.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 26 |
| PHASE2 | 5 |
| PHASE3 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT01622803 | PHASE3 | WITHDRAWN | Comparison Between Two Methods of Bilateral Stenting for Malignant Hilar Obstruction |
| NCT07012772 | PHASE2 | RECRUITING | COMBO Endoscopy Oropharyngeal Airway in Sedated Endoscopic Retrograde Cholangiopancreatography for Patients |
| NCT07051980 | PHASE2 | RECRUITING | Feasibility and Safety of Supraglottic Oxygen Delivery Via an Endotracheal Tube for Non-intubated ERCP Anesthesia: A Two-Stage Phase II Clinical Study |
| NCT01688375 | PHASE2 | UNKNOWN | The Effect of Ursodeoxycholic Acid in Liver Functional Restoration of Patients With Obstructive Jaundice |
| NCT02166840 | PHASE2 | COMPLETED | Metal or Plastic Stents to Relieve Obstruction of Obstructive Jaundice Prior to Resection of Periampullary Tumors. |
| NCT02468076 | PHASE2 | COMPLETED | Radiofrequency Ablation for Biliopancreatic Malignancy |
| NCT03977779 | Not specified | RECRUITING | Evaluation of the Use of a Biodegradable Endoprothesis in the Prevention of Post-Endoscopic Retrograde CholoangioPancreatography Pancreatitis |
| NCT06456476 | Not specified | RECRUITING | Patients With Obstructive Jaundice In Sohag University Hospital |
| NCT06541340 | Not specified | RECRUITING | A New Strategy for Preoperative Drainage of Resectable Pancreatic Head Cancer Combined Severe Obstructive Jaundice |
| NCT06754397 | Not specified | NOT_YET_RECRUITING | Diagnostic Accuracy of Magnetic Resonance Cholangiopancreatography in Patients With Obstructive Jaundice |
| NCT07532759 | Not specified | NOT_YET_RECRUITING | Impact of Intraoperative PTCD Catheter Retention Versus Removal on Postoperative Short-term Outcomes After Pancreaticoduodenectomy in Obstructive Jaundice |
| NCT07563569 | Not specified | NOT_YET_RECRUITING | Determinants of Technical Success and Safety in Therapeutic ERCP for Obstructive Jaundice |
| NCT00409864 | Not specified | COMPLETED | Endoscopic Versus Percutaneous Drainage For Hilar Block in Gall Bladder Cancer |
| NCT01191814 | Not specified | COMPLETED | Comparison of Metal and Plastic Stents for Preoperative Biliary Decompression |
| NCT01321203 | Not specified | COMPLETED | Outcome of Carbon Dioxide Versus Air Insufflations During Endoscopic Retrograde Cholangiopancreatography (ERCP) |
| NCT01367821 | Not specified | UNKNOWN | Immune Function in Patients With Obstructive Jaundice |
| NCT01438385 | Not specified | UNKNOWN | Interventional Endoscopy Database for Pancreatico-biliary, Gastrointestinal and Esophageal Disorders |
| NCT01506115 | Not specified | COMPLETED | Safety and Efficacy of Photodynamic Therapy for Bile Duct Invasion of Hepatocellular Carcinoma |
| NCT01675908 | Not specified | COMPLETED | Trial Comparing Metal Versus Plastic Stents for Preoperative Biliary Decompression |
| NCT02797665 | Not specified | UNKNOWN | Treatment of Obstructive Jaundice in Autoimmune Pancreatitis and/or Immunoglobulin G4-related Sclerosing Cholangitis by Corticosteroids |
| NCT03133026 | Not specified | UNKNOWN | Cholangioscopic Assessment of Occluded Biliary Stent and Role of Biliary Radiofrequency Ablation |
| NCT03376945 | Not specified | COMPLETED | Application of n-3 Fatty to Patient of Jaundice |
| NCT03406676 | Not specified | UNKNOWN | Pre-treatment With Methylene Blue Prevent Peri-operative Reduced Systemic Vascular Resistance |
| NCT03491254 | Not specified | UNKNOWN | Investigating the Efficacy and Safety of the Combination Treatment of Huaier Granule and Biliary Drainage for MOJ |
| NCT03510754 | Not specified | COMPLETED | Endoscopic Ultrasound-guided Biliary Drainage for Malignant Biliary Obstruction After Failed ERCP |
| NCT04385147 | Not specified | COMPLETED | Advanced Endoscopy During COVID-19 |
| NCT04823832 | Not specified | COMPLETED | Endoscopic Versus Percutaneous Biliary Drainage for Resectable Pancreatic Head Cancer |
| NCT05155475 | Not specified | COMPLETED | Endoscopic Ultrasound Evaluation of the Common Bile Duct in Patients With Obstructive Jaundice Due to Bilio-pancreatic Malignancies (ECCO Trial) |
| NCT05246176 | Not specified | UNKNOWN | Ultrasonography as a Single Tool for Guided Percutaneous Transhepatic Biliary Drainage in Obstructive Jaundice |
| NCT05556668 | Not specified | COMPLETED | Percutaneous Biodegradable Biliary Stents for the Treatment of Benign Biliary Strictures. |
| NCT05928286 | Not specified | COMPLETED | Remaxol® Used in the Treatment of Patients With Gallstone Disease Complicated With Obstructive Jaundice |
| NCT06093048 | Not specified | UNKNOWN | Endoscopic Retrograde Cholangiopancreatography In Patients Older Than 65Years Old With Obstructive Jaundice: Efficacy And Outcome |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| METHYLENE BLUE CATION | 4 | 3 |
| URSODIOL | 4 | 2 |
| PORFIMER SODIUM | 4 | 1 |
| CHEMBL5409583 | 0 | 1 |
| CHEMBL5429422 | 0 | 1 |
| CHEMBL443232 | 0 | 1 |
| PROTOPORPHYRIN DISODIUM | -1 | 1 |
Related Atlas pages
- Drugs: Methylene Blue Cation, Ursodiol, Porfimer