Ocular cancer

Summary

Ocular cancer (MONDO:0002236) is a cancer (an umbrella term covering 10 Mondo subtypes) and 17 clinical trials. Top therapeutic interventions include belzupacap sarotalocan, esmethadone, and (r,r)-tramadol. A subtype of sensory system cancer — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer
• Umbrella term: 10 Mondo subtypes
• Clinical trials: 17

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	ocular cancer
Mondo ID	MONDO:0002236
MeSH	D005134
DOID	DOID:2174
NCIT	C4767
SNOMED CT	371486001
UMLS	C0496836
MedGen	105418
Anatomy (UBERON)	UBERON:0010230
Is cancer (heuristic)	yes

Also known as: cancer of eye · cancer of eyeball of camera-type eye · cancer of the eye · eye cancer · eye neoplasm · eye neoplasm, malignant · eyeball of camera-type eye cancer · malignant eye neoplasm · malignant eye tumor · malignant eye tumour · malignant eyeball of camera-type eye neoplasm · malignant neoplasm of eye · malignant neoplasm of eyeball of camera-type eye · malignant neoplasm of the eye · malignant ocular neoplasm · malignant ocular tumor · malignant ocular tumour · malignant tumor of eye · malignant tumor of the eye · malignant tumour of eye (+4 more)

Disease family

An umbrella term covering 10 Mondo subtypes.

Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › cancer › nervous system cancer › sensory system cancer › ocular cancer

Related subtypes (6): nasal cavity cancer, malignant ear neoplasm, auditory system cancer, tongue cancer, paranasal sinus cancer, optic tract astrocytoma

Subtypes (10): lacrimal system cancer, eye carcinoma, uveal cancer, retinal cancer, conjunctival cancer, cornea cancer, eye lymphoma, ocular melanoma, eyelid cancer, metastatic malignant neoplasm in the eye

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

0 approved, 1 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.

Drug	Development status
Melatonin	Phase 3 (in late-stage trials)

Clinical trials & evidence

Clinical trials

Clinical trials: 17.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	10
PHASE1/PHASE2	3
PHASE2	2
PHASE1	2

Top trials by phase / activity

NCT	Phase	Status	Title
NCT06643884	PHASE2	RECRUITING	Suprachoroidal Administration in Subjects With Metastases to the Choroid
NCT07136181	PHASE1/PHASE2	RECRUITING	Evaluation of the Safety, Efficacy, and Pharmacokinetics of NBM-BMX in Patients With Metastatic Uveal Melanoma
NCT00111046	PHASE1/PHASE2	UNKNOWN	Pain Relief - Tramadol Versus Ibuprofen
NCT00588640	PHASE1/PHASE2	COMPLETED	Study of D-Methadone in Patients With Chronic Pain
NCT01151748	PHASE2	WITHDRAWN	Intra-arterial Chemotherapy for Advanced Intraocular Retinoblastoma
NCT00020267	PHASE1	COMPLETED	Vaccine Therapy in Treating Patients With Metastatic Cancer
NCT05236049	PHASE1	COMPLETED	Use of an Allograft Set-up (SclerFIX) as Replacement of Sclera Graft for Support of Enucleation Implant
NCT01653080	Not specified	ACTIVE_NOT_RECRUITING	MRI in Diagnosing Solid Tumors of the Eye and Orbit
NCT03713268	Not specified	RECRUITING	Intraoperative OCT Guidance of Intraocular Surgery II
NCT05051384	Not specified	ACTIVE_NOT_RECRUITING	Superb Microvascular Intraocular Tumor Imaging Study (SMITIS)
NCT07449195	Not specified	RECRUITING	A Study Comparing Two Optical Coherence Tomography Devices in People With Ocular Tumors
NCT00601744	Not specified	COMPLETED	Social-Psychological Aspects of Orbital Exenteration
NCT01072253	Not specified	COMPLETED	Quality of Life of Eye Amputated Patients in Denmark
NCT01135849	Not specified	COMPLETED	B-Receptor Signaling in Cardiomyopathy
NCT04695015	Not specified	UNKNOWN	Research of Pathological Imaging Diagnosis of Ocular Tumors Based on New Artificial Intelligence Algorithm
NCT05645341	Not specified	COMPLETED	Artificial Intelligence-assisted Screening of Malignant Pigmented Tumors on the Ocular Surface
NCT05853315	Not specified	COMPLETED	BCC Excision Revisited

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
BELZUPACAP SAROTALOCAN	3	1
ESMETHADONE	3	1
(R,R)-TRAMADOL	0	1