Ocular surface squamous neoplasia

Summary

Ocular surface squamous neoplasia (MONDO:0971056) is a disease and 2 clinical trials. A subtype of squamous cell neoplasm — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: <1 / 1 000 000 (United States) [Orphanet-validated]
• Clinical trials: 2

Clinical features

Epidemiology

Prevalence records

1 prevalence record(s), Orphanet:

Type	Class	Value	Geography	Validation
Annual incidence	<1 / 1 000 000	0.03	United States	Validated

Identifiers

Disease identifiers

Field	Value
Canonical name	ocular surface squamous neoplasia
Mondo ID	MONDO:0971056
Orphanet	659744
UMLS	C4761284
MedGen	1787978
GARD	0027162
Is cancer (heuristic)	no

Disease family

Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › epithelial neoplasm › squamous cell neoplasm › ocular surface squamous neoplasia

Related subtypes (6): vaginal squamous tumor, vulvar squamous neoplasm, ovarian squamous cell neoplasm, squamous cell carcinoma, craniopharyngioma, squamous cell intraepithelial neoplasia

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 2.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	2

Top trials by phase / activity

NCT	Phase	Status	Title
NCT04704648	Not specified	RECRUITING	Feasibility Study of Ocular Surface Squamous Neoplasia Surgical Excision in People Living With HIV in Sub-Saharan Africa
NCT05797415	Not specified	RECRUITING	Sentinel Lymph Node Biopsy in Ocular Surface and Adnexal Cancers