Omphalitis

Summary

Omphalitis (MONDO:0021562) is a disease and 11 clinical trials. Top therapeutic interventions include chlorhexidine. A subtype of inflammatory disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 11

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	omphalitis
Mondo ID	MONDO:0021562
NCIT	C116008
SNOMED CT	239095007
UMLS	C0028992
MedGen	508000
Is cancer (heuristic)	no

Also known as: omphalitis

Disease family

This is a subtype of inflammatory disease. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by developmental or physiological process › inflammatory disease › omphalitis

Related subtypes (93): chorioamnionitis, pyometritis, uvulitis, mastoiditis, pelvic inflammatory disease, tonsillitis, nasopharyngitis, petrositis, nephritis, esophagitis, geniculate ganglionitis, epicondylitis, labyrinthitis, lymphadenitis, cheilitis, neuritis, vaginitis, hepatitis, pharyngitis, hidradenitis, gastroenteritis, dermatitis, bursitis, laryngitis, keratitis, endocervicitis, conjunctivitis, spondylitis, thyroiditis, diverticulitis, neuronitis, mediastinitis, epididymitis, blepharitis, cholangitis, dacryoadenitis, fasciitis, chronic inflammation of lacrimal passage, dacryocystitis, periostitis, gastritis, pancreatitis, periodontitis, encephalomyelitis, placental villitis, prostatitis, urethritis, otitis media, perianal Crohn disease, proctitis, arthritic joint disease, oral tuberculosis, parotitis, pericarditis, sinusitis, cystitis, panniculitis, balanitis, chronic inflammatory demyelinating polyradiculoneuropathy, glossitis, mastitis, oophoritis, orchitis, perinephritis, pulpitis, rheumatic heart disease, vulvitis, thromboangiitis obliterans, STING-associated vasculopathy with onset in infancy, endophthalmitis, chronic granulomatous disease, IgG4-related pachymeningitis, vasculitis, chronic pneumonitis of infancy, uveitis, mucositis, amnionitis, diaphragmitis, gonococcal cervicitis, posthitis, myositis disease, ear infection, radiculitis, tracheobronchitis, ureteritis, enthesitis, inflammation of heart layer, serositis, pneumonitis, immune reconstitution inflammatory syndrome, multiple evanescent white dot syndrome, isolated anogenital granulomatosis, myelin oligodendrocyte glycoprotein antibody-associated disease

Subtypes (1): funisitis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 11.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	6
PHASE3	3
PHASE4	1
PHASE2	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT02606565	PHASE4	COMPLETED	Efficacy of Umbilical Cord Cleansing With a Single Application of 4% Chlorhexidine for the Prevention of Newborn Infections in Uganda: a Randomized Controlled Trial
NCT00434408	PHASE3	COMPLETED	Impact of Umbilical Cord Cleansing With 4.0% Chlorhexidine on Neonatal Mortality
NCT00682006	PHASE3	COMPLETED	Topical Application of Chlorhexidine to the Umbilical Cord for Prevention of Omphalitis and Neonatal Mortality in Rural District of Pakistan
NCT01528852	PHASE3	COMPLETED	Chlorhexidine Cordcare for Reduction in Neonatal Mortality and Omphalitis
NCT06002295	PHASE2	COMPLETED	A Comparative Analysis of 4% Chlorhexidine Versus Methylated Spirit as Prophylaxis of Omphalitis and Sepsis in Newborns
NCT04798833	Not specified	ACTIVE_NOT_RECRUITING	Newborn Care Kit to Save Lives in GB, Pakistan
NCT01556867	Not specified	TERMINATED	Evaluation of Two Strategies for Umbilical Cord Care : Dry Cord Care Versus Antiseptic on the Incidence of Omphalitis in Healthy Term Newborn
NCT01687621	Not specified	COMPLETED	Omphalitis Community Based Algorithm Validation Study
NCT01751945	Not specified	COMPLETED	Improved Accessibility of EmONC Services for Maternal and Newborn Health: a Community Based Project
NCT02624622	Not specified	TERMINATED	Chlorhexidine Cord Care for Newborn Infants in Kenya
NCT02694679	Not specified	COMPLETED	Randomized Controlled Trial of Social Network Targeting in Honduras

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
CHLORHEXIDINE	4	2