Optic papillitis
diseaseOn this page
Also known as Choked discChoked discsChoked diskChoked disksdecreased intraocular pressure associated papilledemadecreased intraocular pressure-associated papilledemadisk, Chokeddisks, Chokededema of the optic diskedema, optic discedema, optic diskedema, optic papillaedema, retinalEdemas, optic discEdemas, optic diskEdemas, retinalincreased intracranial pressure associated papilledemaincreased intracranial pressure-associated papilledemainflammation of optic discinflammation of optic disk
Summary
Optic papillitis (MONDO:0006879) is a disease and 15 clinical trials. Top therapeutic interventions include anakinra and semaglutide. A subtype of retinitis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 15
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | optic papillitis |
| Mondo ID | MONDO:0006879 |
| EFO | EFO:1001074 |
| MeSH | D010211 |
| DOID | DOID:10175 |
| ICD-10-CM | H46.0 |
| SNOMED CT | 423341008, 73221001 |
| UMLS | C0030353 |
| MedGen | 10565 |
| GARD | 0024496 |
| MedDRA | 10030948 |
| Is cancer (heuristic) | no |
Also known as: Choked disc · Choked discs · Choked disk · Choked disks · decreased intraocular pressure associated papilledema · decreased intraocular pressure-associated papilledema · disk, Choked · disks, Choked · edema of the optic disk · edema, optic disc · edema, optic disk · edema, optic papilla · edema, retinal · Edemas, optic disc · Edemas, optic disk · Edemas, retinal · increased intracranial pressure associated papilledema · increased intracranial pressure-associated papilledema · inflammation of optic disc · inflammation of optic disk (+20 more)
Disease family
This is a subtype of retinitis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › nervous system disorder › retinal disorder › retinitis › optic papillitis
Related subtypes (4): cytomegalovirus retinitis, histoplasmosis retinitis, acute retinal necrosis syndrome, retinal vasculitis
Subtypes (1): neuroretinitis
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
Drugs indicated for this disease
No approved or late-stage (phase ≥3) drug is indicated for this disease; the following are in earlier-phase trials only.
Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Dexamethasone.
Clinical trials & evidence
Clinical trials
Clinical trials: 15.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 9 |
| PHASE4 | 2 |
| PHASE2/PHASE3 | 1 |
| PHASE1/PHASE2 | 1 |
| PHASE1 | 1 |
| EARLY_PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT04501367 | PHASE4 | UNKNOWN | Assessing the Efficacy and Safety fo DEXTENZA, Sustained Release Dexamethasone 0.4 mg Insert(s) for the Treatment of Pain, Inflammation, and Cystoid Macular Edema Following 27 Gauge Vitrectomy With Internal Limiting Membrane Peel for the Treatment of Retinal Edema Associated With Macular Pucker. |
| NCT06027567 | PHASE4 | COMPLETED | The Effect of an Anti-obesity Drug, Semaglutide, as Treatment in New-onset Idiopathic Intracranial Hypertension (IIH) Compared to Standard Weight Management (Dietician) With Regards to Change in Weight and Intracranial Pressure |
| NCT01273727 | PHASE2/PHASE3 | COMPLETED | Ozurdex for Macular Edema Post Membrane Peeling |
| NCT00069329 | PHASE1/PHASE2 | TERMINATED | Anakinra to Treat Patients With Neonatal Onset Multisystem Inflammatory Disease |
| NCT03373292 | PHASE1 | UNKNOWN | Endovascular Stenting Treatment for Patients With Internal Jugular Vein Stenosis |
| NCT04690608 | EARLY_PHASE1 | UNKNOWN | Suprachoroidal Injection of Triamcinolone Acetonide in Resistant Diabetic Macular Edema, CRVO, Pseudophakic Cystoid Macular Edema and Diabetic Macular Edema Following Pars Plana Vitrectomy |
| NCT06286696 | Not specified | NOT_YET_RECRUITING | Optic Nerve Sheath Diameter in Hypertensive Emergency |
| NCT01847638 | Not specified | COMPLETED | Prolensa (Bromfenac) 0.07% QD vs. Ilevro (Nepafenac) 0.3% QD for Treatment of Ocular Inflammation Post Cataract Surgery |
| NCT02410148 | Not specified | UNKNOWN | aICP in Glaucoma and Papilledema |
| NCT02992262 | Not specified | UNKNOWN | Ocular Point of Care Ultrasound (POCUS) to Detect Optic Disc Swelling in Comparison to Ophthalmologic Examination |
| NCT03178760 | Not specified | COMPLETED | Determination of Normal Measures of Optic Nerve Sheath Diameter in Children |
| NCT03273179 | Not specified | UNKNOWN | Cerebral Venous Sinus Thrombosis: Re-exploration of Clinical Assessment Scales |
| NCT03753893 | Not specified | COMPLETED | Ocular Manifestations in Rheumatic Diseases |
| NCT05130385 | Not specified | UNKNOWN | High Resolution Optical Coherence Tomography |
| NCT06390579 | Not specified | COMPLETED | Building Research With Artificial Intelligence in Neuro-Ophthalmology |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| ANAKINRA | 4 | 1 |
| SEMAGLUTIDE | 4 | 1 |
| CHEMBL15720 | 0 | 1 |
| CHEMBL4556788 | 0 | 1 |
| CHEMBL4752331 | 0 | 1 |
| CHEMBL6147864 | 0 | 1 |
| CHEMBL5220618 | 0 | 1 |
Related Atlas pages
- Drugs: Anakinra, Semaglutide