Osgood-Schlatter disease
diseaseOn this page
Also known as aseptic necrosis of the tibial tubercleOsgood-Schlatter's diseaseosteochondritis of the tibial tubercleOsteochondrosis of the tibial tubercle
Summary
Osgood-Schlatter disease (MONDO:0004241) is a disease and 14 clinical trials. Top therapeutic interventions include dextrose. A subtype of bone inflammation disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Prevalence: Unknown (Worldwide)
- Phenotypes (HPO): 8
- Clinical trials: 14
Clinical features
Signs & symptoms
Clinical features (HPO)
8 HPO clinical features (Orphanet curated; top 8 by frequency):
| HPO ID | Term | Frequency |
|---|---|---|
| HP:0030839 | Knee pain | Very frequent (80-99%) |
| HP:0001288 | Gait disturbance | Frequent (30-79%) |
| HP:0003045 | Abnormal patella morphology | Frequent (30-79%) |
| HP:0003066 | Limited knee extension | Frequent (30-79%) |
| HP:0006456 | Irregular proximal tibial epiphyses | Frequent (30-79%) |
| HP:0009046 | Difficulty running | Frequent (30-79%) |
| HP:0002362 | Shuffling gait | Occasional (5-29%) |
| HP:0030866 | Large knee | Occasional (5-29%) |
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | Osgood-Schlatter disease |
| Mondo ID | MONDO:0004241 |
| Orphanet | 97335 |
| DOID | DOID:7489 |
| ICD-10-CM | M92.52 |
| NCIT | C34874 |
| SNOMED CT | 430506003, 72047008 |
| UMLS | C0029376 |
| MedGen | 10489 |
| GARD | 0019364 |
| MedDRA | 10031130 |
| Is cancer (heuristic) | no |
Also known as: aseptic necrosis of the tibial tubercle · Osgood-Schlatter disease · Osgood-Schlatter’s disease · osteochondritis of the tibial tubercle · Osteochondrosis of the tibial tubercle
Disease family
This is a subtype of bone inflammation disease. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › skeletal system disorder › bone disorder › bone inflammation disease › Osgood-Schlatter disease
Related subtypes (5): mastoiditis, epicondylitis, osteomyelitis, arthritic joint disease, Caffey disease
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 14.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 13 |
| PHASE1/PHASE2 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT01300754 | PHASE1/PHASE2 | COMPLETED | Effectiveness of Dextrose Injection for Osgood-Schlatter Disease |
| NCT06995794 | Not specified | NOT_YET_RECRUITING | Osgood-Schlatter Disease in Athletic Children |
| NCT07096037 | Not specified | NOT_YET_RECRUITING | Safety and Efficacy of Urtica Dioica Cataplasm in the Management of Osgood-Schlatter Disease in Young Athletes |
| NCT07446517 | Not specified | RECRUITING | Low-Level Laser Therapy for Osgood-Schlatter or Sever Pain in Youth Athletes |
| NCT07521280 | Not specified | NOT_YET_RECRUITING | Individualized Rehabilitation for Osgood-Schlatter or Sever Pain in Youth Athletes |
| NCT02799394 | Not specified | COMPLETED | Effect of Activity Modification and Exercises in Young Adolescents With Osgood Schlatter Disease. |
| NCT02824172 | Not specified | COMPLETED | Treatment of the Osgood Schlatter |
| NCT03589001 | Not specified | COMPLETED | 24 Month Follow-up of Patients With Osgood Schlatter (OSD) |
| NCT04716608 | Not specified | COMPLETED | Treatment for Osgood Schlatter Patients With a Physiotherapy Program |
| NCT05174182 | Not specified | COMPLETED | A Comparison of Two Different Treatment Approaches for Adolescents With Osgood Schlatter |
| NCT05789095 | Not specified | COMPLETED | Rate of Torque Development in Adolescents With Osgood-Schlatter |
| NCT05826340 | Not specified | UNKNOWN | Getting Kids With Osgood Schlatter Back to Performing Without Pain |
| NCT06993363 | Not specified | COMPLETED | Kinesotaping and Strengthening Exercises in Treatment of Osgood-Schlatter Disease |
| NCT07590128 | Not specified | COMPLETED | Combined Physical Therapy and Hold-Relax Technique for Adolescent Osgood-Schlatter Knee Pain |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| DEXTROSE | 4 | 1 |
| CHEMBL423707 | 0 | 1 |
Related Atlas pages
- Drugs: Dextrose